Stomach and gut
What research found here. What was shown to help comes first, then the risks reported, most common first.
Stomach and gut
Strong several reviews agree · Moderate one review or consistent trials · Limited one or a few small studies · Untested no study in people, listed with what it rests on
Shown to help61
Nausea in pregnancy
Shown to improve nausea scores in pregnant women over placebo. Vomiting episodes did not differ significantly.
The numbers and sources
- Effect
- In 12 RCTs (1,278 pregnant women), ginger improved nausea scores against placebo (MD 1.20, 95% CI 0.56 to 1.84, I² 0%). Vomiting episodes did not differ significantly (MD 0.72, 95% CI -0.03 to 1.46) [1]. In 6 placebo-controlled trials (508 women), about 1 g a day for at least 4 days was associated with 5 times the odds of improvement [2].
- Population
- Pregnant women with nausea and vomiting [1][2].
- Sources
- [1], [2]
- Caveats
- Review [1] rated the evidence low quality with variable outcome reporting. Review [2] notes heterogeneity among trials. Review [1] included English-language trials only.
Stress ulcer bleeding in intensive care
Shown to lower clinically important gut bleeding in critically ill patients, about 3 to 5 fewer per 100 at higher bleeding risk, with no clear effect on deaths.
Compared with placebo or no prophylaxis [6][7]; proton pump inhibitors [7]
The numbers and sources
- Effect
- Against placebo or no prophylaxis, H2 blockers reduced clinically important gut bleeding (OR 0.46, 95% CI 0.27 to 0.79), 4.6% fewer in the highest-risk and 3.1% fewer in high-risk patients, with no effect on mortality (OR 0.96) [6]. An updated analysis found the same direction (RR 0.67, 95% CI 0.48 to 0.94), a larger reduction with proton pump inhibitors than H2 blockers (RR 0.69), and no mortality difference (RR 0.98) [7].
- Population
- 72 trials with 12,660 patients [6]; 74 trials with 39,569 patients [7].
- Sources
- [6], [7]
- Caveats
- Both analyses come from the same research group, and the second updates the first. Results apply to critically ill patients only.
Irritable bowel syndrome, compared with education, support or routine care
Shown to relieve irritable bowel syndrome more than education, supportive therapy or routine care, with adequate relief in about 33% to 41% against 17% in the largest trial.
Compared with education and/or support, or routine care [3]; control conditions the source abstract does not describe [4]; group educational supportive therapy [5]; online self-guided psychoeducation [6]
The numbers and sources
- Effect
- A network meta-analysis of 41 trials found gut-directed hypnotherapy reduced the chance of remaining symptomatic (RR 0.67, 95% CI 0.49 to 0.91), and in refractory IBS it beat education, support or routine care [3]. Across 8 trials, hypnosis gave adequate symptom relief more often than control at the end of therapy (RR 1.69, 95% CI 1.14 to 2.51, number needed to treat 5) and at long-term follow-up (RR 2.17, number needed to treat 3) [4]. In 354 adults referred from primary or secondary care, adequate relief at 3 months was 40.8% with individual hypnotherapy, 33.2% with group hypnotherapy and 16.7% with educational supportive therapy (OR 2.9, 95% CI 1.2 to 7.4), and 40.8%, 49.5% and 22.6% at 12 months [5]. In 230 people, an abdominal pain response was seen in 48% with in-person hypnotherapy, 33% with a smartphone program and 22% with psychoeducation [6]. The American College of Gastroenterology guideline states: "We suggest that gut-directed psychotherapy be used to treat global IBS symptoms" [7], a conditional recommendation based on very low-quality evidence according to NCCIH [2].
- Population
- 4,072 adults in 41 trials of psychological therapies [3]. 464 adults in 8 trials, mostly with IBS that had not responded to usual treatment [4]. 354 adults in 11 Dutch hospitals [5]. 230 people aged 16 to 75 [6].
- Sources
- [3], [4], [5], [6], [7], [2]
- Caveats
- Trials were at high risk of bias, with funnel plot asymmetry suggesting effects are overestimated [3]. A 2007 Cochrane review of 4 small early trials judged their quality too poor for conclusions [8]. No trial can blind patients to receiving hypnotherapy.
Nausea and vomiting after surgery
Shown to lower vomiting in the 24 hours after surgery by about 45% against placebo, though several other antiemetics and combinations ranked higher.
Compared with placebo [1][2][3]; dexamethasone, droperidol, granisetron, aprepitant and drug combinations, in network comparisons [1]
The numbers and sources
- Effect
- In a network meta-analysis, ondansetron reduced vomiting within 24 hours against placebo (RR 0.55, 95% CI 0.51 to 0.60, high certainty), ranking 13th of 28 single drugs. Combinations of drugs generally reduced vomiting more [1]. An earlier Cochrane review found eight drugs, ondansetron among them, prevented postoperative nausea and vomiting with relative risks of 0.60 to 0.80, and estimated that where 80 of 100 people would be sick, about 28 benefit from a drug [2]. In two label trials in women, a single 16 mg dose before anesthesia reduced nausea and vomiting more than placebo [3].
- Population
- 97,516 adults in 585 studies, 246 of them of ondansetron [1]; 103,237 people in 737 studies [2]; 865 women having inpatient surgery [3].
- Sources
- [1], [2], [3]
- Caveats
- Most studies were small and 83% of participants were women [1]. The label states no trials of the tablet were done in men [3]. Low doses showed no clinically important benefit [1].
Vomiting in children with stomach bugs
Shown to raise the share of children who stopped vomiting and to cut the need for IV fluids by about half against placebo in children with gastroenteritis.
Compared with placebo [4][5][6]
The numbers and sources
- Effect
- Oral ondansetron raised the share who stopped vomiting (RR 1.34, NNT 5), and lowered IV rehydration in the emergency department (RR 0.41, NNT 5) and immediate hospital admission (RR 0.40, NNT 17) [4]. A later review found fewer oral rehydration failures (RR 0.5, 95% CI 0.37 to 0.69), less IV rehydration (RR 0.45, 95% CI 0.31 to 0.63) and fewer admissions (RR 0.53, 95% CI 0.29 to 0.97), with no difference in vomiting cessation after 4, 24 or 48 hours [5]. A single dose lowered oral rehydration failure (RR 0.43, 95% CI 0.34 to 0.55), IV hydration (RR 0.44, 95% CI 0.34 to 0.57) and hospitalization within 8 hours (RR 0.49, 95% CI 0.32 to 0.75) [6].
- Population
- 1,020 children in seven trials [4]; 1,215 children in 10 trials [5]; 2,146 children and adolescents in 13 trials [6].
- Sources
- [4], [5], [6]
- Caveats
- Return visits to the emergency department did not differ (RR 1.14) [5][6]. Diarrhea was reported as a side effect in four of five ondansetron studies [4].
Side effects and cure rates during H. pylori treatment
Shown to cut side effects during H. pylori treatment about in half with S. boulardii, and to raise cure rates slightly, 1 more per 18 treated.
The numbers and sources
- Effect
- Added to eradication therapy, Saccharomyces boulardii raised eradication in 15 adult RCTs (RR 1.07, 95% CI 1.03 to 1.10, number needed to treat 18) and cut overall adverse events from 36.0% to 19.7% (RR 0.51, 95% CI 0.39 to 0.66) [1]. With bismuth quadruple therapy, 11 RCTs (2,295 patients) found higher eradication (RR 1.12, 95% CI 1.06 to 1.18) and fewer adverse events (RR 0.46, 95% CI 0.28 to 0.74) [2]. Lactobacillus added to therapy raised eradication in 32 RCTs (RR 1.10, 95% CI 1.05 to 1.14) and lowered adverse events (RR 0.70, 95% CI 0.58 to 0.84) [3]. A review of 14 Lactobacillus RCTs found higher eradication (RR 1.04) and less diarrhea (RR 0.45), with no significant change in other side effects [4].
- Population
- Adults and children with H. pylori infection [1][3]. Adults [2][4].
- Sources
- [1], [2], [3], [4]
- Caveats
- Certainty was low for adverse events in [1]. Eradication gains with Lactobacillus appeared only with triple therapy [3]. The Lactobacillus reviews disagree on side effects other than diarrhea [3][4].
Ulcerative colitis
Shown to raise clinical remission about twofold added to standard treatment in adults with ulcerative colitis. Reviews differ on endoscopic remission.
The numbers and sources
- Effect
- Across 8 RCTs (482 patients), curcumin added to standard treatment raised clinical remission against placebo (RR 2.33, 95% CI 1.25 to 4.34, I² 80%). Endoscopic remission did not differ significantly (RR 4.17, 95% CI 0.63 to 27.71) [22]. A meta-analysis of 6 RCTs (385 participants) found more clinical remission (RR 2.10, 95% CI 1.13 to 3.89) and no significant difference in endoscopic remission [23]. Another of 6 RCTs (349 patients) found more clinical remission (OR 5.18, 95% CI 1.84 to 14.56) and endoscopic remission (OR 5.69, 95% CI 1.28 to 25.27) with curcumin added to mesalamine [24].
- Population
- Adults with ulcerative colitis, mostly on mesalamine [22][23][24].
- Sources
- [22], [23], [24]
- Caveats
- Heterogeneity was high and the trials overlap across the reviews [22]. Some trials gave curcumin as an enema rather than by mouth [24].
Nausea and vomiting after surgery
Shown to cut nausea after surgery by about a third compared with sham, with stimulation of one wrist point. It did not differ from antinausea drugs.
Compared with sham treatment [11]; antinausea drugs [11]
The numbers and sources
- Effect
- Stimulating the PC6 wrist point lowered nausea (RR 0.68, 95% CI 0.60 to 0.77, 40 trials, 4,742 participants), vomiting (RR 0.60, 95% CI 0.51 to 0.71) and the need for rescue drugs (RR 0.64) against sham. It did not differ from six antinausea drugs, including ondansetron and dexamethasone, for nausea (RR 0.91, 95% CI 0.75 to 1.10) or vomiting (RR 0.93). Added to a drug, it lowered vomiting (RR 0.56) and not nausea [11].
- Population
- 59 trials with 7,667 surgical patients [11].
- Sources
- [11]
- Caveats
- The review pooled needles, electrical stimulation, acupressure and wristbands. Heterogeneity was substantial and the sham evidence was rated low in quality [11].
Binge eating disorder
Shown to cut binge eating by about 1.4 to 1.7 more days a week than placebo on lisdexamfetamine in adults with moderate to severe binge eating disorder.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In two 12-week trials, lisdexamfetamine 50 or 70 mg a day reduced binge eating days per week more than placebo, by 1.35 days (95% CI 1.01 to 1.70) and 1.66 days (95% CI 1.28 to 2.04) [7]. In an earlier 11-week trial, four weeks free of binge eating was reached by 50.0% on 70 mg, 42.2% on 50 mg and 21.3% on placebo, and 30 mg did not differ from placebo [8]. Among people who had responded to open-label treatment, relapse over 6 months occurred in 3.7% who stayed on lisdexamfetamine and 32.1% switched to placebo (HR 0.09, 95% CI 0.04 to 0.23) [9].
- Population
- 383 and 390 adults in two 12-week trials [7]; adults in an 11-week dose-ranging trial [8]; 275 responders randomized after open-label treatment, 87% women [9].
- Sources
- [7], [8], [9]
- Caveats
- The evidence is for lisdexamfetamine, the only stimulant approved for this use, and comes from manufacturer-run trials of 11 to 12 weeks plus one withdrawal trial. The withdrawal trial enrolled only people who had already responded.
Constipation from pelvic floor dyssynergia, compared with laxatives and other treatment
Shown to improve constipation from pelvic floor dyssynergia more often than laxatives, diazepam or other non-biofeedback treatment, in trials rated low in quality.
Compared with laxatives with diet and lifestyle advice, oral diazepam, and standard care [11]; non-biofeedback therapy [12]
The numbers and sources
- Effect
- Against non-biofeedback therapy, biofeedback raised the odds of clinical improvement (OR 3.63, 95% CI 1.10 to 11.93, 6 trials), and 63% of treated patients improved [12]. In one trial, 80% given biofeedback improved at 6 and 12 months against 22% given laxatives (RR 3.65). In another, 70% improved against 23% on diazepam (RR 3.00). Some surgical procedures did better than biofeedback [11].
- Population
- 725 adults in 11 trials [12]. 931 adults in 17 trials, most with dyssynergic defecation [11].
- Sources
- [12], [11]
- Caveats
- Sixteen of 17 trials were at high risk of bias for blinding, and heterogeneity was high [11][12].
Death in people hospitalized with pneumonia or pancreatitis
Linked to more deaths in hospital patients: a BUN of 20 mg/dL or above went with 4.6 times the odds of death in acute pancreatitis.
The numbers and sources
- Effect
- In 1,043 cases of acute pancreatitis from 3 cohorts, a BUN of 20 mg/dL or higher at admission went with an odds ratio for death of 4.6 (95% CI 2.5 to 8.3), and any rise in BUN at 24 hours with an odds ratio of 4.3 (2.3 to 7.9) [10]. In 1,068 adults hospitalized with community-acquired pneumonia, urea above 7 mmol/L (a BUN above about 20 mg/dL) became one of the five items of the CURB-65 severity score, in which 30-day mortality ran from 0.7% at a score of 0 to 57% at a score of 5 [11].
- Population
- 1,043 cases of acute pancreatitis in US and Dutch cohorts [10]. 1,068 patients with pneumonia in the UK, New Zealand and the Netherlands, mean age 64 [11].
- Sources
- [10], [11]
- Caveats
- Observational, in people acutely ill in hospital. These cut points are not reference ranges for people who are well. The pneumonia study reports urea in mmol/L, and the mg/dL figure here is converted with the factor on this page.
Colorectal cancer
Linked to 17% lower colorectal cancer per extra 400 g a day of total dairy and 9% lower per 200 g of milk, in pooled cohorts. Cheese showed no link.
Compared with 400 g a day less total dairy, 200 g a day less milk or 50 g a day less cheese, in a dose-response model [12]
The numbers and sources
- Effect
- The relative risk of colorectal cancer was 0.83 (95% CI 0.78 to 0.88) per 400 g a day of total dairy, 0.91 (95% CI 0.85 to 0.94) per 200 g a day of milk and 0.96 (95% CI 0.83 to 1.12) per 50 g a day of cheese. The links appeared in men and women and were limited to colon cancer [12].
- Population
- 19 cohort studies [12].
- Sources
- [12]
- Caveats
- Observational. The search ran to 2010 [12].
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Bowel habits and gut symptoms in healthy adults
Shown to increase bowel movement frequency and ease gut symptoms in healthy adults, in one meta-analysis of 19 trials rated mostly low in certainty.
Compared with control groups the abstract does not describe [2]
The numbers and sources
- Effect
- Fermented foods raised bowel movement frequency (MD 0.60, 95% CI 0.04 to 1.16), softened stool on the Bristol scale (MD 0.25, 95% CI 0.03 to 0.47), eased gastrointestinal symptoms (SMD -0.60, 95% CI -1.05 to -0.15) and shortened intestinal transit time (MD -13.65, 95% CI -21.88 to -5.43) [2].
- Population
- 4,328 healthy adults in 25 studies, 19 randomized trials pooled [2].
- Sources
- [2]
- Caveats
- Heterogeneity was high (I² 72% to 95%) and the certainty of evidence was rated mostly low [2]. The trials used different foods.
Irritable bowel syndrome
Shown to raise the share of people with irritable bowel syndrome reporting symptom relief by 22%, in one meta-analysis. Pain and bloating scores did not change significantly.
Compared with control groups the abstract does not describe [3]
The numbers and sources
- Effect
- Symptom relief was more frequent with fermented foods (RR 1.22, 95% CI 1.04 to 1.42, I² 0%, 12 trials), and global symptom scores fell slightly (SMD -0.15, 95% CI -0.29 to -0.02). Abdominal pain and bloating scores did not improve significantly. Fermented milk alone showed RR 1.19 (95% CI 1.01 to 1.39) [3].
- Population
- 1,264 people with irritable bowel syndrome in 16 randomized trials [3].
- Sources
- [3]
- Caveats
- The authors advise caution given limits of the evidence [3]. Many products were fermented milks with added probiotic strains.
Chronic constipation
Shown to help more adults with chronic constipation, 66% against 41% on control, mostly at more than 10 g a day.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Across 16 RCTs (1,251 adults), 66% responded to fiber and 41% to control (RR 1.48, 95% CI 1.17 to 1.88, I² 57%). Fiber raised stool frequency (SMD 0.72, 95% CI 0.36 to 1.08, I² 86%) and improved stool consistency (SMD 0.32). Psyllium and pectin had significant effects, and response was higher only above 10 g a day [3].
- Population
- Adults with chronic constipation [3].
- Sources
- [3]
- Caveats
- Heterogeneity was considerable. The stool frequency gain appeared only at higher doses and at 4 weeks or more [3].
Irritable bowel syndrome
Shown to lower persistent IBS symptoms in adults, with soluble fiber helping one extra person for every 7 treated. Bran did not differ from control.
The numbers and sources
- Effect
- Across 14 RCTs (906 patients), fiber lowered the risk of persistent IBS symptoms (RR 0.86, 95% CI 0.80 to 0.94, number needed to treat 10). Soluble fiber showed RR 0.83 (95% CI 0.73 to 0.94, number needed to treat 7), and bran did not differ from control (RR 0.90, 95% CI 0.79 to 1.03) [4].
- Population
- Adults with IBS [4].
- Sources
- [4]
- Caveats
- No significant heterogeneity, but the search ended in December 2013.
Nausea after surgery
Shown to lower nausea scores in the 12 hours after surgery. Vomiting and anti-nausea drug use did not differ outside the recovery room.
The numbers and sources
- Effect
- In 14 RCTs (1,506 patients), nausea scores were lower with ginger than placebo at 2, 6 and 12 hours after surgery (SMD -1.10, -1.54 and -2.04). Outside the recovery room, vomiting, combined nausea and vomiting, and use of anti-nausea drugs did not differ [3].
- Population
- 1,506 surgical patients [3].
- Sources
- [3]
- Caveats
- Confidence intervals were wide, for example -3.67 to -0.41 at 12 hours [3].
Heartburn relief in reflux disease
Shown to relieve heartburn more often than placebo in adults with reflux symptoms, and less often than proton pump inhibitors.
Compared with placebo [1][2]; proton pump inhibitors [1]
The numbers and sources
- Effect
- In people treated without an endoscopy first, the risk ratio for heartburn remission against placebo was 0.77 (95% CI 0.60 to 0.99) for H2 blockers, a value below 1 favoring the drug. In people with a normal endoscopy it was 0.84 (95% CI 0.74 to 0.95). Proton pump inhibitors did better than H2 blockers (RR 0.66 and 0.78) [1]. In a label trial in reflux without erosions, 82% improved on famotidine 20 mg twice daily, 69% on 40 mg at bedtime and 62% on placebo at 6 weeks [2].
- Population
- 34 randomized trials of short-term treatment in adults with reflux symptoms [1]; 376 adults with reflux symptoms and no erosions on endoscopy [2].
- Sources
- [1], [2]
- Caveats
- Only two placebo-controlled trials of H2 blockers in each group of the review [1]. Famotidine 40 mg at bedtime was not shown to beat placebo in the label trial [2].
Healing erosive esophagitis
Shown to heal erosive esophagitis more often than placebo, 69% against 29% at 12 weeks on famotidine 40 mg twice daily, but less often than proton pump inhibitors.
Compared with placebo [3][2]; proton pump inhibitors [3]; ranitidine [2]
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- H2 blockers healed esophagitis more often than placebo (RR 0.74, 95% CI 0.66 to 0.84, a value below 1 favoring the drug), and proton pump inhibitors healed it more often than H2 blockers (RR 0.51, 95% CI 0.44 to 0.59) [3]. In a US label trial, healing at 12 weeks was 69% on famotidine 40 mg twice daily, 54% on 20 mg twice daily and 29% on placebo. In an international trial, 12-week healing was 71% on famotidine 40 mg twice daily and 60% on ranitidine 150 mg twice daily [2].
- Population
- 10 trials with 1,241 people comparing H2 blockers with placebo, within a review of 134 trials [3]; 318 adults in the US trial and 440 in the international trial [2].
- Sources
- [3], [2]
- Caveats
- Cochrane withdrew the 2007 review in 2011 [3]. Symptom relief did not differ between famotidine and ranitidine [2].
Healing duodenal and gastric ulcers
Shown to heal more duodenal and gastric ulcers than placebo. In one trial, 83% of duodenal ulcers healed on famotidine by 8 weeks against 45% on placebo.
Compared with placebo [2]
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In a US duodenal ulcer trial, 70% healed by week 4 on famotidine 40 mg at bedtime and 67% on 20 mg twice daily, against 31% on placebo. By week 8, 83% on famotidine and 45% on placebo had healed. In two gastric ulcer trials, 8-week healing was 78% and 80% on famotidine 40 mg at bedtime against 64% and 54% on placebo [2].
- Population
- 270 adult outpatients with duodenal ulcer, and 149 and 294 adults with gastric ulcer, in double-blind trials [2].
- Sources
- [2]
- Caveats
- Label trials. Pain relief at week 8 did not differ from placebo in the gastric ulcer trials, though pain resolved sooner on famotidine [2].
Keeping duodenal ulcers from returning
Shown to halve duodenal ulcer return over 12 months on famotidine 20 mg at bedtime, 23% against 57% on placebo in one trial and 36% against 76% in another.
Compared with placebo [2]
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the US trial, cumulative duodenal ulcer recurrence within 12 months was 23% on famotidine and 57% on placebo. In the international trial it was 36% and 76% [2].
- Population
- 178 and 632 adults with healed duodenal ulcers in two randomized double-blind trials [2].
- Sources
- [2]
- Caveats
- Controlled trials did not go beyond one year [2].
Preventing ulcers in people taking NSAIDs or aspirin
Shown to prevent ulcers in people on NSAIDs or low-dose aspirin. With aspirin, gastric ulcers developed in 3.4% on famotidine against 15.0% on placebo over 12 weeks.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- In NSAID users, standard-dose H2 blockers reduced endoscopic duodenal ulcers (RR 0.36, 95% CI 0.18 to 0.74) but not gastric ulcers (RR 0.73, 95% CI 0.50 to 1.09). Double-dose H2 blockers reduced gastric ulcers (RR 0.44, 95% CI 0.26 to 0.74) [4]. In people taking low-dose aspirin, at 12 weeks gastric ulcers developed in 3.4% on famotidine and 15.0% on placebo (OR 0.20), duodenal ulcers in 0.5% and 8.5% (OR 0.05), and erosive esophagitis in 4.4% and 19.0% (OR 0.20) [5].
- Population
- 40 randomized trials of NSAID ulcer prevention [4]; 404 adults taking aspirin 75 to 325 mg a day, without ulcers at the start [5].
- Sources
- [4], [5]
- Caveats
- Endoscopic ulcers stand in for bleeding ulcers. In the aspirin trial, 82 people without a final endoscopy were counted as normal [5].
Fullness
Shown to raise fullness ratings after higher-protein meals in tightly controlled preload studies of healthy adults.
Compared with diets with less protein
The numbers and sources
- Effect
- In 5 preload studies, higher-protein preloads raised fullness over 2 to 4 hours more than lower-protein preloads (2,435.74 mm·240 min, 95% CI 1,375.18 to 3,496.31). A directional count of 28 studies also favored higher protein [7]. In weight-loss trials, 3 of 5 studies reported greater satiety with high protein [1].
- Population
- Healthy adults given intact protein by mouth [7]; adults in weight-loss trials [1].
- Sources
- [1], [7]
- Caveats
- The authors caution against extending these results to everyday eating, body weight or health outcomes [7].
Nausea and stomach symptoms
Shown to cut nausea and vomiting after surgery by about half against placebo across three trials, with far more sedation.
The numbers and sources
- Effect
- Mirtazapine given before surgery reduced postoperative nausea and vomiting against placebo (RR 0.44, 95% CI 0.32 to 0.62) and gave rates similar to ondansetron in one trial (RR 0.96, 95% CI 0.48 to 1.94). Sedation was more frequent (RR 22.47, 95% CI 5.61 to 89.93) [8]. In people with functional dyspepsia not helped by standard drugs, 8 weeks of mirtazapine improved dyspepsia symptom scores, including fullness after meals, early satiation, nausea and vomiting, and increased weight against a control group [9]. In depression trials, mirtazapine caused less nausea or vomiting than SSRIs [2].
- Population
- Three placebo-controlled trials in surgical patients [8]; 120 patients with functional dyspepsia [9]; 2,626 participants in 12 trials against SSRIs [2].
- Sources
- [8], [9], [2]
- Caveats
- Not an approved use. Evidence quality for the surgery analysis was rated moderate to low, and the dyspepsia trial was single-center. No trial in chemotherapy nausea or pregnancy nausea was sourced for this page.
Nausea and vomiting with chemotherapy
Shown to prevent vomiting with chemotherapy in controlled trials, with no vomiting over 3 days in 61% on ondansetron against 6% on placebo in one trial.
Compared with placebo [3]; a historical placebo group [3]
The numbers and sources
- Effect
- In a placebo-controlled trial with a cyclophosphamide and doxorubicin regimen, 61% on ondansetron 8 mg had no vomiting over 3 days, against 6% on placebo, and 21% against 71% had more than 2 episodes or withdrew. With cisplatin regimens, 66% on a single 24 mg dose had no vomiting and no rescue medicine over 24 hours, better than a historical placebo group in which more than 90% vomited [3].
- Population
- 67 adults in the placebo-controlled trial and 357 adults in the cisplatin trial, as reported in the label [3].
- Sources
- [3]
- Caveats
- The cisplatin trials compared with a historical control, not a concurrent placebo group [3].
Irritable bowel syndrome with diarrhea
Shown to firm stools and reduce diarrhea symptoms against placebo in pooled trials, with about 5 treated for one extra stool responder, but not to relieve abdominal pain.
Compared with placebo [8]
The numbers and sources
- Effect
- In the TRITON trial, 40.5% on ondansetron and 27.9% on placebo met the FDA composite endpoint, a difference that was not significant, while stool consistency improved (adjusted mean difference -0.7). Pooled with two similar trials, ondansetron improved the composite endpoint (RR of not responding 0.86, 95% CI 0.75 to 0.98, NNT 9) and stool response (RR 0.65, 95% CI 0.52 to 0.82, NNT 5), but not abdominal pain response (RR 0.95, 95% CI 0.74 to 1.20) [8].
- Population
- 80 adults in TRITON over 12 weeks, and 327 in the pooled analysis of three trials [8].
- Sources
- [8]
- Caveats
- TRITON recruited 80 of a planned 400 patients [8].
Infant colic and excessive crying
Shown to cut crying by about 1.3 hours a day in pooled manual therapy trials, which included chiropractic and osteopathy and mostly had parents who knew the treatment.
Compared with no physical treatment, sham treatment or a drug, depending on the trial [10]; no treatment for 3 weeks [11]
The numbers and sources
- Effect
- Manual therapy reduced crying by 1.27 hours a day (95% CI -2.19 to -0.36). Effects on sleep and parent-child relations were inconclusive, and parent-reported global improvement showed no effect [10]. In 103 infants with colic, three osteopathic treatments lowered parents' psychological stress by 3.5 points on a 0 to 10 scale more than 3 weeks without treatment (95% CI 2.6 to 4.4), with similar changes in crying time and intensity [11].
- Population
- 7 randomized trials among 19 studies of otherwise healthy crying infants [10]. 103 infants aged 1 week to 3 months in Germany [11].
- Sources
- [10], [11]
- Caveats
- The review pooled osteopathy with chiropractic and massage [10]. Crying was reported by parents, who knew whether their baby was treated in the 2025 trial [11]. Results from trials with parents blinded are on the chiropractic page.
C. difficile diarrhea during antibiotics
Shown to halve C. difficile diarrhea during antibiotics, 1.6% against 3.2%, with benefit only where baseline risk was above 5% in one analysis.
The numbers and sources
- Effect
- In the 2025 Cochrane update, 38 trials (13,179 participants) found C. difficile-associated diarrhea in 1.6% on probiotics and 3.2% on control (RR 0.50, 95% CI 0.38 to 0.64, low certainty, number needed to treat 65) [11]. The 2017 version found 1.5% against 4.0% in 31 trials (RR 0.40) [12]. In its trials with baseline risk above 5%, rates were 3.1% versus 11.6% (RR 0.30), and trials with baseline risk of 5% or less showed no difference [12]. A 2025 review of 4 studies in hospitalized patients found no significant difference (OR 0.99, 95% CI 0.56 to 1.7) [13].
- Population
- Adults and children on antibiotics, 47 studies with 15,260 participants [11]. Hospitalized patients, 4 studies [13].
- Sources
- [11], [12], [13]
- Caveats
- Detection of C. difficile in stool did not differ (RR 0.87, 95% CI 0.68 to 1.11) [11]. 28 studies had authors linked to probiotic companies or company funding [11]. The baseline-risk subgroup in [12] was post hoc. The small hospital review had high heterogeneity [13].
Antibiotic-associated diarrhea
Shown to lower antibiotic-associated diarrhea, from 19% to 8% in children and 27% to 23% overall, with low to moderate certainty.
The numbers and sources
- Effect
- Across 33 studies (6,352 children), antibiotic-associated diarrhea occurred in 8% on probiotics and 19% on control (RR 0.45, 95% CI 0.36 to 0.56, I² 57%, number needed to treat 9, moderate certainty). At 5 billion CFU a day or more, rates were 8% versus 23% (RR 0.37) [14]. In 40 trials (13,419 adults and children), antibiotic-associated diarrhea occurred in 23% on probiotics and 27.4% on control (RR 0.67, 95% CI 0.57 to 0.78, low certainty) [11].
- Population
- Children 0 to 18 on antibiotics [14]. Adults and children on antibiotics [11].
- Sources
- [14], [11]
- Caveats
- 20 of 33 pediatric studies were at high risk of bias [14]. Certainty in [11] was downgraded for few events or publication bias.
Ulcerative colitis
Shown to raise remission in active ulcerative colitis over placebo, with low certainty. Effect on keeping remission was uncertain.
The numbers and sources
- Effect
- A Cochrane review of 14 studies (865 participants) found more clinical remission in active disease on probiotics than placebo (RR 1.73, 95% CI 1.19 to 2.54, 9 studies, 594 participants, low certainty, number needed to treat 5). Remission did not differ from 5-ASA (RR 0.92, 95% CI 0.73 to 1.16, 1 study) [20]. For keeping remission, a Cochrane review of 12 studies (1,473 participants) found it uncertain whether relapse differed from placebo (RR 0.87, 95% CI 0.63 to 1.18) and little or no difference from 5-ASA (RR 1.01, 95% CI 0.84 to 1.22) [21].
- Population
- Mostly adults with mild to moderate ulcerative colitis [20][21].
- Sources
- [20], [21]
- Caveats
- Risk of bias was high in all but two or three studies in each review, and certainty ranged from moderate to very low [20][21].
Irritable bowel syndrome
Shown to lower IBS symptom severity scores in adults, with effects differing by strain and no clear change in quality of life.
The numbers and sources
- Effect
- Across 40 RCTs, probiotics lowered the IBS symptom severity score by 33.42 points (95% CI 10.88 to 55.96) and did not significantly change IBS quality of life (MD 1.79, 95% CI -3.00 to 6.57) [24]. In 12 RCTs (1,303 patients), multistrain products lowered the score by 43.66 points (95% CI 21.44 to 65.89), and IBS-specific quality of life and abdominal pain scores did not change significantly [25]. A strain-level review found benefit for Bifidobacterium longum 35624, Lactobacillus rhamnosus GG, Lactiplantibacillus plantarum 299v, Saccharomyces cerevisiae CNCM I-3856 and Bacillus coagulans Unique IS2, and none for E. coli Nissle 1917, L. gasseri BNR17 or L. casei Shirota [26]. In 53 RCTs (5,545 patients), adverse events were no more common than placebo [27]. In children with IBS, 3 RCTs found less abdominal pain (SMD -0.95, 95% CI -1.63 to -0.27) [28].
- Population
- Adults with IBS [24][25][26][27]. 604 children in 6 RCTs [28].
- Sources
- [24], [25], [26], [27], [28]
- Caveats
- Certainty was low, mainly from inconsistency, and trial sequential analysis found the evidence had not reached the required information size [24]. Heterogeneity was 99% in [25]. Effects differ by strain [26][27].
Heartburn relief in reflux disease
Shown to relieve heartburn more often than placebo or H2 blockers in adults with reflux symptoms, with a larger effect when treated without an endoscopy first.
Compared with placebo [1]; H2 blockers and prokinetic drugs [1]
The numbers and sources
- Effect
- In people treated for reflux symptoms without an endoscopy first, the risk ratio for heartburn remission against placebo was 0.37 (95% CI 0.32 to 0.44) for proton pump inhibitors and 0.77 (95% CI 0.60 to 0.99) for H2 blockers, a value below 1 favoring the drug. Against H2 blockers directly, proton pump inhibitors had a risk ratio of 0.66 (95% CI 0.60 to 0.73). In people with heartburn and a normal endoscopy, the risk ratio against placebo was 0.71 (95% CI 0.65 to 0.78) [1].
- Population
- 34 randomized trials of short-term treatment in adults with reflux symptoms, 15 treating without endoscopy, 15 in people with a normal endoscopy and 4 in both [1].
- Sources
- [1]
- Caveats
- Short-term trials only. The placebo comparison in people treated without endoscopy rests on two trials [1].
Healing erosive esophagitis
Shown to heal erosive esophagitis more often than placebo or H2 blockers. In one label trial, 92.6% healed on pantoprazole 40 mg by 8 weeks against 39.7% on placebo.
Compared with placebo [2][3]; H2 blockers [2]; nizatidine [3]
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Standard-dose proton pump inhibitors healed esophagitis more often than placebo (RR 0.22, 95% CI 0.15 to 0.31, a value below 1 favoring the drug) and more often than H2 blockers alone or with prokinetics (RR 0.51, 95% CI 0.44 to 0.59). H2 blockers also beat placebo (RR 0.74) [2]. In a US placebo-controlled trial, 8-week healing was 66.0% on pantoprazole 10 mg, 83.5% on 20 mg and 92.6% on 40 mg against 39.7% on placebo. Against nizatidine 150 mg twice daily, 8-week healing was 79.2% and 82.9% on pantoprazole 20 and 40 mg and 41.4% on nizatidine [3].
- Population
- 134 trials with 35,978 people with esophagitis, of which 5 trials with 965 people compared a standard dose with placebo [2]; 603 adults with grade 2 or higher esophagitis in the placebo trial and 243 in the nizatidine trial [3].
- Sources
- [2], [3]
- Caveats
- Cochrane withdrew the 2007 review in 2011 [2]. The label trials were analyzed per protocol, and the placebo group had 68 people [3].
Keeping esophagitis healed
Shown to keep healed esophagitis from returning more often than ranitidine, with 83% to 86% still healed at 12 months on pantoprazole 40 mg against 35% to 37%.
Compared with ranitidine 150 mg twice daily [3]
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In two identical 12-month trials, the share still healed at 12 months was 86% and 83% on pantoprazole 40 mg, 70% and 72% on 20 mg, and 35% and 37% on ranitidine. Daytime heartburn episodes in month 12 averaged 2.9 on pantoprazole 40 mg against 17.5 on ranitidine [3].
- Population
- 386 and 404 adults with endoscopically healed erosive esophagitis [3].
- Sources
- [3]
- Caveats
- The comparison was an H2 blocker, not placebo. Controlled studies did not extend beyond 12 months [3].
Esomeprazole against other proton pump inhibitors
Shown to heal slightly more erosive esophagitis with esomeprazole than with other proton pump inhibitors, about 1 extra healed for every 25 treated, more in severe disease.
Compared with other proton pump inhibitors [4]
The numbers and sources
- Effect
- At 8 weeks, esomeprazole raised the chance of healing by 5% relative to other proton pump inhibitors (RR 1.05, 95% CI 1.02 to 1.08), an absolute difference of 4% and a number needed to treat of 25. By severity grade A to D, the numbers needed to treat were 50, 33, 14 and 8. Symptom relief at 4 weeks was 8% more likely (RR 1.08, 95% CI 1.05 to 1.11) [4].
- Population
- 10 randomized trials with 15,316 people with erosive esophagitis [4].
- Sources
- [4]
- Caveats
- The abstract does not name the comparator drugs or doses one by one. The trials were published from 1995 to 2005. The gap was small in milder disease [4].
Rebleeding from stomach and duodenal ulcers
Shown to cut rebleeding, surgery and repeat endoscopy after ulcer bleeding, about 1 rebleed prevented per 13 treated, with no overall change in deaths.
Compared with placebo or H2 blockers [5]
The numbers and sources
- Effect
- Proton pump inhibitors cut rebleeding (OR 0.49, 95% CI 0.37 to 0.65, number needed to treat 13), surgery (OR 0.61, 95% CI 0.48 to 0.78, number needed to treat 34) and repeat endoscopic treatment (OR 0.32, 95% CI 0.20 to 0.51). Deaths did not differ overall (OR 1.01, 95% CI 0.74 to 1.40). Deaths fell in Asian trials (OR 0.35) and in people with active bleeding or a visible vessel (OR 0.53) [5].
- Population
- 24 randomized trials with 4,373 people with bleeding peptic ulcers [5].
- Sources
- [5]
- Caveats
- Heterogeneity was present for rebleeding. The mortality benefit appeared only in subgroups [5].
Preventing ulcers in people taking NSAIDs
Shown to prevent stomach and duodenal ulcers seen on endoscopy in people taking NSAIDs, with gastric ulcers in about 5% on esomeprazole against 12% to 17% on placebo.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Proton pump inhibitors lowered the risk of endoscopic gastric ulcers (RR 0.40, 95% CI 0.32 to 0.51) and duodenal ulcers in long-term NSAID users. The review found ulcer complications such as bleeding were shown to fall only with high-dose misoprostol [6]. In two 26-week trials in people aged 60 or older or with a past ulcer, 95.4% and 94.7% stayed free of gastric ulcers on esomeprazole 20 mg against 88.2% and 83.3% on placebo [7].
- Population
- 40 randomized trials of drugs to prevent NSAID ulcers [6]; 1,429 adults taking NSAIDs, median age 66, in two trials [7].
- Sources
- [6], [7]
- Caveats
- Endoscopic ulcers are a stand-in for bleeding ulcers. The esomeprazole trials did not show a drop in duodenal ulcers because there were too few [7].
Stress ulcer bleeding in intensive care
Shown to lower clinically important upper gut bleeding in critically ill adults, 1.0% against 3.5% in one trial, with no difference in deaths at 90 days.
Compared with placebo [10][11]
The numbers and sources
- Effect
- In ventilated adults, clinically important upper gut bleeding occurred in 1.0% on pantoprazole and 3.5% on placebo (HR 0.30, 95% CI 0.19 to 0.47). Deaths at 90 days were 29.1% and 30.9% (HR 0.94, 95% CI 0.85 to 1.04) [10]. In adults with an unplanned ICU admission, clinically important bleeding occurred in 2.5% on pantoprazole and 4.2% on placebo. Deaths at 90 days were 31.1% and 30.4% (RR 1.02, 95% CI 0.91 to 1.13), and a composite of bleeding, pneumonia, C. difficile infection and heart ischemia did not differ [11].
- Population
- 4,821 adults on invasive ventilation in 68 ICUs [10]; 3,298 adults at risk of gut bleeding in European ICUs [11].
- Sources
- [10], [11]
- Caveats
- Both trials used intravenous pantoprazole in critically ill adults. The results do not apply to people outside intensive care.
Helicobacter pylori ulcers, as part of eradication therapy
Shown, as part of eradication therapy with antibiotics, to heal more duodenal ulcers than ulcer-healing drugs alone, with 12.4% of ulcers persisting against 18.7%.
Compared with ulcer-healing drugs alone or no treatment [12]
The numbers and sources
- Effect
- In duodenal ulcer healing, eradication therapy plus an ulcer-healing drug left ulcers persisting in 12.4% against 18.7% on the ulcer-healing drug alone (RR 0.66, 95% CI 0.58 to 0.76), and in 21.7% against 58.5% with no treatment (RR 0.37). Differences for gastric ulcer healing were imprecise (RR 1.23, 95% CI 0.90 to 1.68) [12].
- Population
- 55 randomized trials in people with peptic ulcer and H. pylori infection [12].
- Sources
- [12]
- Caveats
- Eradication regimens combine an acid reducer with antibiotics, so this block does not isolate the proton pump inhibitor. The evidence was rated low to very low quality [12].
Functional dyspepsia
Shown to relieve overall indigestion symptoms slightly more than placebo in functional dyspepsia, with about 11 treated for one extra person helped.
Compared with placebo [13]; H2 blockers and prokinetic drugs [13]
The numbers and sources
- Effect
- Proton pump inhibitors lowered the risk of persisting dyspepsia symptoms against placebo (RR 0.88, 95% CI 0.82 to 0.94), a number needed to treat of 11. Against H2 blockers the difference was not clear (RR 0.88, 95% CI 0.74 to 1.04). Low and standard doses performed similarly [13].
- Population
- 25 randomized trials with 8,453 participants, 18 trials with 6,172 people for the placebo comparison [13].
- Sources
- [13]
- Caveats
- Moderate-quality evidence. Results did not differ by H. pylori status [13].
Bulimia nervosa
Shown to raise remission from binge eating in bulimia nervosa across antidepressants, with about 9 treated for one extra remission. The SSRI trials were all of fluoxetine.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Across antidepressant classes, the risk of not reaching remission from binge episodes was lower than on placebo (RR 0.88, 95% CI 0.83 to 0.93), a number needed to treat of 9 (95% CI 6 to 16) over a mean 8 weeks. A 50% or greater drop in binge episodes was also more likely (RR for no improvement 0.63, 95% CI 0.55 to 0.74), a number needed to treat of 4. Fewer people dropped out on fluoxetine than on placebo [21].
- Population
- People with bulimia nervosa in 16 placebo-controlled trials, 3 of them of fluoxetine [21].
- Sources
- [21]
- Caveats
- The evidence within this class is for fluoxetine only, and the pooled numbers include tricyclics and MAOIs. The review dates from 2003, and 92% of the placebo group did not reach remission [21].
Nausea and vomiting in pregnancy
Shown to ease nausea in pregnancy slightly, under 1 point on nausea scales. Vomiting did not differ significantly in one trial.
The numbers and sources
- Effect
- Pooled, pyridoxine alone or with another agent improved nausea scores by 0.78 points on the Rhodes scale (95% CI 0.26 to 1.31) and 0.75 points on the PUQE scale (95% CI 0.28 to 1.22) [1]. In a Thai trial, nausea scores fell more on 30 mg a day than on placebo over 5 days (P = 0.0008). Vomiting episodes did not significantly differ (P = 0.055) [2].
- Population
- 18 studies [1]; 342 women at 17 weeks' gestation or earlier [2].
- Sources
- [1], [2], [3]
- Caveats
- Sources disagree on strength. A 2015 Cochrane review of 41 trials found only limited evidence for vitamin B6 and could not pool most outcomes [3]. The 2023 pooled scores mix pyridoxine alone with combinations [1].
Bowel habits
Shown to raise stool weight by 3.7 g per extra gram of wheat fiber a day, and to shorten slow gut transit, in pooled intervention studies.
Compared with lower intakes of wheat fiber, in a regression across intervention studies [14]
The numbers and sources
- Effect
- Each extra gram a day of wheat fiber raised total stool weight by 3.7 g a day (95% CI 3.50 to 3.84) and stool frequency by 0.004 times a day. In people whose transit time was over 48 hours, it shortened by 0.78 hours per extra gram (95% CI 0.53 to 1.04). Too few studies of non-wheat cereal fibers allowed analysis [14].
- Population
- 65 intervention studies in generally healthy people [14].
- Sources
- [14]
- Caveats
- Most of the effect came from wheat bran [14]. Fiber in general is on its own page.
Chronic constipation, electroacupuncture
One trial of 1,075 people found electroacupuncture added about one complete bowel movement a week more than sham, through 12 weeks after treatment.
Compared with sham electroacupuncture at non-acupoints [20]
The numbers and sources
- Effect
- Weekly complete spontaneous bowel movements rose by 1.76 with electroacupuncture and 0.87 with sham over weeks 1 to 8 (difference 0.90, 95% CI 0.74 to 1.10), and by 1.96 and 0.89 over weeks 9 to 20. Three or more a week were reached by 31.3% and 12.1% during treatment [20].
- Population
- 1,075 people with chronic severe functional constipation at 15 hospitals in China [20].
- Sources
- [20]
- Caveats
- Acupuncturists could not be blinded and longer-term follow-up was not assessed [20].
- Why limited
- This rests on one trial, of 1,075 people. Strength counts independent studies that agree, so one trial is limited at any size.
Irritable bowel syndrome
One trial found low-dose amitriptyline improved irritable bowel syndrome symptoms more than placebo over 6 months in primary care.
Compared with placebo [10]
The numbers and sources
- Effect
- At 6 months, symptom severity scores improved by 27.0 points more on amitriptyline than placebo (95% CI -46.9 to -7.10). 20% stopped amitriptyline, 13% for adverse events, against 26% and 9% on placebo [10].
- Population
- 463 adults with irritable bowel syndrome still symptomatic after first-line treatments, in 55 English general practices [10].
- Sources
- [10]
- Caveats
- One trial. The difference was below the trial's 35-point threshold for a clinically important change [10].
Constipation from pelvic floor dyssynergia, compared with sham biofeedback
One trial found 4.6 complete bowel movements a week with biofeedback against 2.8 with sham biofeedback at 3 months.
Compared with sham biofeedback [11]
The numbers and sources
- Effect
- At 3 months, complete spontaneous bowel movements averaged 4.6 a week with manometry biofeedback and 2.8 with sham biofeedback (mean difference 1.80, 95% CI 1.25 to 2.35) [11].
- Population
- 52 adults with chronic constipation and dyssynergic defecation in one trial [11].
- Sources
- [11]
- Caveats
- One small trial, and the Cochrane review rated the evidence low or very low [11].
Gut health in people without bowel disease
Small trials of butyrate enemas in healthy volunteers found lower gut pain sensitivity and changes in colon antioxidant markers. No trial of oral butyrate in healthy people was located.
The numbers and sources
- Effect
- In 11 healthy volunteers, a week of nightly butyrate enemas lowered pain, urge and discomfort during rectal balloon stretching, with pain scores 23.9% lower at 50 mmol/L and 42.1% lower at 100 mmol/L than on saline at low pressure [12]. In 16 healthy volunteers, 2 weeks of daily 100 mM butyrate enemas raised glutathione (p < 0.05) and lowered uric acid (p < 0.01) in colon biopsies against saline. CRP, calprotectin, a gut damage marker and inflammation scores on histology did not differ [13].
- Population
- 11 healthy adults in a crossover trial [12]. 16 healthy adults in a crossover trial [13].
- Sources
- [12], [13]
- Caveats
- Both trials gave butyrate into the rectum, not by mouth as supplements are sold. They were small and short, and measured markers and sensitivity, not symptoms in daily life [12][13].
Inflammatory bowel disease
Case reports: 10 people with ulcerative colitis or Crohn's disease, selected because they responded, reported improvement on mostly carnivore ketogenic diets.
Compared with no comparison group [4]
The numbers and sources
- Effect
- Six people with ulcerative colitis and four with Crohn's disease reported improvement of 72 to 165 points on the Inflammatory Bowel Disease Questionnaire [4].
- Population
- 10 adults with confirmed inflammatory bowel disease, recruited through a social media survey [4].
- Sources
- [4]
- Caveats
- A case series that included only people whose disease responded to the diet, so it cannot show how often it helps. No comparison group [4].
Irritable bowel syndrome
One pilot study of 18 people with irritable bowel syndrome found less abdominal pain and more regular stools after 1 to 4 weeks, with no control group.
Compared with before treatment, in the same people [5]
The numbers and sources
- Effect
- Abdominal pain, satisfaction and distress scores improved (p < 0.001). In constipation-dominant IBS, bowel movements rose from 1.68 to 3.78 a week and hard stools fell from 45% to 13%. In diarrhea-dominant IBS, loose stools fell from 62% to 28%. Only mild adverse events occurred [5].
- Population
- 18 patients with IBS, 12 constipation-dominant and 6 diarrhea-dominant, using a self-administered irrigation device [5].
- Sources
- [5]
- Caveats
- No control group, so placebo and natural change cannot be separated. The authors call for studies of placebo effects [5].
Gut microbiome diversity
One 17-week trial of 36 adults found a high fermented food diet steadily raised gut microbiome diversity, which a high-fiber diet did not.
Compared with a high-fiber diet, with changes measured over time in each group [8]
The numbers and sources
- Effect
- The high fermented food diet steadily increased microbiota diversity. The high-fiber diet left community diversity stable. The primary outcome, a cytokine response score, did not change [8].
- Population
- 36 healthy adults, 18 in each group [8].
- Sources
- [8]
- Caveats
- One small trial. Microbiome diversity is not itself a health outcome.
Indigestion
One trial found a steamed ginger extract improved gut symptom scores over 12 weeks in adults with functional dyspepsia.
The numbers and sources
- Effect
- In one 12-week placebo-controlled trial of a steamed ginger extract, 480 mg a day improved total gastrointestinal symptom scores and the abdominal pain, constipation, indigestion and reflux sub-scores against placebo. The abstract reports p-values, not effect sizes [10].
- Population
- 80 adults with mild to moderate functional dyspepsia [10].
- Sources
- [10]
- Caveats
- One trial of one branded extract.
Constipation
One trial found better constipation scores and more frequent bowel movements on konjac glucomannan in male Taekwondo athletes with functional constipation.
The numbers and sources
- Effect
- In one 8-week double-blind trial, konjac glucomannan improved constipation symptom scores, constipation quality of life, bowel movement frequency and bowel function scores against placebo (p < 0.05 for all) [8].
- Population
- Elite male Taekwondo athletes with functional constipation by Rome IV criteria, in China [8].
- Sources
- [8]
- Caveats
- One trial. The abstract does not give the number enrolled, the dose or effect sizes [8].
Colorectal polyps
One trial found polyp growth slowed over 12 months only in adults aged 63 or younger with small colorectal polyps.
Nausea and vomiting with radiotherapy
Small trials found ondansetron prevented vomiting from radiotherapy better than placebo, metoclopramide and prochlorperazine.
Compared with placebo, metoclopramide and prochlorperazine [3]
The numbers and sources
- Effect
- Ondansetron 8 mg prevented vomiting from total body irradiation more than placebo, and gave more complete control of vomiting than metoclopramide with single high-dose abdominal radiotherapy and than prochlorperazine with daily fractionated abdominal radiotherapy [3].
- Population
- 20, 105 and 135 patients in three trials, as reported in the label [3].
- Sources
- [3]
- Caveats
- The label gives no rates for these trials, and the placebo-controlled trial had 20 patients [3].
Nausea and vomiting in pregnancy
One small trial in pregnancy found ondansetron eased nausea more than doxylamine with pyridoxine over 5 days.
Compared with doxylamine with pyridoxine [7]
The numbers and sources
- Effect
- Median nausea scores fell 51 mm on a 100 mm scale on ondansetron 4 mg against 20 mm on doxylamine with pyridoxine, and vomiting scores fell 41 against 17 mm. Sedation and constipation did not differ [7].
- Population
- 36 pregnant women with nausea and vomiting, 30 completing follow-up [7].
- Sources
- [7]
- Caveats
- A very small trial with uneven follow-up (72% and 94%) and no placebo group [7]. Use in pregnancy is off-label.
C. difficile recurrence alongside treatment
One trial found fewer C. difficile recurrences, 1.7% against 13.1%, when S. boulardii was added to vancomycin.
The numbers and sources
- Effect
- In 120 patients with mild to moderate C. difficile infection treated with vancomycin, 500 mg of Saccharomyces boulardii twice a day for 10 days did not change clinical cure (98.4% against 98.3%) and lowered recurrence (1.7% against 13.1%) compared with placebo [43].
- Population
- 120 patients with toxin-positive C. difficile infection [43].
- Sources
- [43]
- Caveats
- One trial. Adverse events did not differ [43].
Appetite and food intake
One small trial found about 525 fewer calories eaten at a test lunch, and less hunger and craving, at week 3 in adults without diabetes.
The numbers and sources
- Effect
- At week 3, tirzepatide cut energy intake at a self-serve lunch by 524.6 kcal more than placebo (95% CI -648.1 to -401.0). Self-reported appetite, food cravings, tendency to overeat and hunger fell against placebo [8].
- Population
- 114 adults without diabetes, BMI 27 to 50, in a 6-week phase 1 trial [8].
- Sources
- [8]
- Caveats
- One small trial that measured a single test meal.
Acute pancreatitis
One cohort of 116,550 Danish adults linked non-fasting triglycerides of 177 mg/dL and above to more acute pancreatitis, about 9 times more at 443 mg/dL or above.
The numbers and sources
- Effect
- Against triglycerides below 89 mg/dL, multivariable adjusted hazard ratios for acute pancreatitis were 1.6 (95% CI 1.0 to 2.6) at 89 to 176 mg/dL, 2.3 (1.3 to 4.0) at 177 to 265 mg/dL and 8.7 (3.7 to 20.0) at 443 mg/dL or above, where the rate was 12 events per 10,000 person-years. The hazard ratio was 1.17 (95% CI 1.10 to 1.24) per 89 mg/dL higher triglycerides [21]. Guideline bodies place the level of clinically significant pancreatitis risk higher, at 500 mg/dL in a US panel and above 880 mg/dL in European documents [2][5][6].
- Population
- 116,550 people from two Copenhagen general population studies, median follow-up 6.7 years, 434 cases of acute pancreatitis [21].
- Sources
- [21], [2], [5], [6]
- Caveats
- Observational, with few events in the highest band, so its interval is wide. Results were similar after stratifying by alcohol intake and gallstone disease [21].
Cancer
Small trials found higher tumor response added to chemotherapy in women with advanced breast cancer, without placebo. A stomach trial measured markers, not cancer.
The numbers and sources
- Effect
- In 120 women with locally advanced or metastatic breast cancer, adding 1 g a day of curcumin with 1% piperine to chemotherapy for 12 to 24 weeks raised objective response from 8.33% to 38.33% at 4 weeks after treatment and from 10.64% to 43.40% at 12 weeks [46]. In 48 people with precancerous stomach changes, 1,000 mg a day of Meriva for 6 months lowered IL-1beta in the stomach lining, while histology and DNA damage did not differ from placebo [47].
- Population
- Women with breast cancer on chemotherapy [46]; adults with atrophic gastritis or intestinal metaplasia in Puerto Rico and Honduras [47].
- Sources
- [46], [47]
- Caveats
- Two small trials. The breast cancer trial compared chemotherapy alone with no placebo, and its abstract gives no progression-free survival figures [46]. The stomach trial measured markers, not cancer cases [47].
Cancer
Linked to about 15% lower total cancer incidence in a small number of cohort studies. Colorectal cancer did not differ significantly in one cohort.
Compared with omnivores, in cohort studies [5]; nonvegetarians in the same Seventh-day Adventist cohort in North America [6]
The numbers and sources
- Effect
- In cohort studies, vegan diets were linked to lower total cancer incidence (RR 0.85, 95% CI 0.75 to 0.95) [5]. In the Adventist cohort, colorectal cancer in vegans did not differ significantly from nonvegetarians (HR 0.84, 95% CI 0.59 to 1.19) [6].
- Population
- Adults in prospective cohorts [5]; 77,659 Seventh-day Adventists followed a mean 7.3 years [6]. Observational.
- Sources
- [5], [6]
- Caveats
- Observational. The review notes the vegan result came from a limited number of studies [5].
Appetite
Small trials found less desire to eat after one meal with a bean extract, and more fullness over 2 months with a bean and artichoke blend, against placebo.
The numbers and sources
- Effect
- In 12 healthy volunteers, 100 mg of a bean extract with a mixed meal lowered the desire to eat over 3 hours against placebo (P = 0.02), and blood ghrelin did not rebound in the third hour as it did on placebo (P = 0.04) [9]. In 39 overweight adults, an extract of Phaseolus vulgaris with artichoke (Cynara scolymus) for 2 months raised satiation scores and lowered the susceptibility-to-hunger score, which did not change on placebo [10]. In rats, a bean extract lowered food intake and body weight gain in a dose-dependent way, an effect blocked by a CCK receptor antagonist [11].
- Population
- 12 healthy volunteers, one meal [9]. 39 overweight adults, 20 on the blend and 19 on placebo [10]. Rats [11].
- Sources
- [9], [10], [11]
- Caveats
- Two small trials. The first tested a single meal [9], and the second a combination with artichoke, so the bean extract's share is unknown [10]. Appetite was self-rated.
Reported risks169
Loss of appetite and weight loss
Shown to cause loss of appetite in 22% to 36% on extended-release mixed amphetamine salts against 2% to 3% on placebo, across children, adolescents and adults.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- On extended-release mixed amphetamine salts, loss of appetite was reported by 22% of children against 2% on placebo, 36% of adolescents against 2% and 33% of adults against 3%. Weight loss was reported by 4%, 9% and 10% against 0 on placebo in each group [17]. On extended-release methylphenidate in adults, decreased appetite was reported by 25% against 7% [21]. In children, amphetamines raised the rate of decreased appetite (RR 6.31, 95% CI 2.58 to 15.46) [3].
- Population
- 374 children, 233 adolescents and 191 adults on the drug in placebo-controlled trials of 3 to 4 weeks [17]; 415 adults on methylphenidate and 212 on placebo in two trials [21]; 2,467 children and adolescents in 11 studies [3].
- Sources
- [17], [21], [3]
- Caveats
- Short trials. The label describes appetite loss as dose-related in adolescents [17].
Dry mouth, headache, stomach ache and anxiety
Shown to cause dry mouth in 35% of adults against 5% on placebo, with headache, stomach ache, nausea and anxiety also more frequent than placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In adults on extended-release mixed amphetamine salts: dry mouth 35% vs 5% on placebo, headache 26% vs 13%, nausea 8% vs 3%, anxiety 8% vs 5% and dizziness 7% vs 0. In children: abdominal pain 14% vs 10%, emotional lability 9% vs 2% and vomiting 7% vs 4%. In the adult trial, 12.0% on the drug and 1.6% on placebo stopped because of adverse events [17]. In adults on extended-release methylphenidate: headache 22% vs 16%, dry mouth 14% vs 4%, nausea 13% vs 3% and anxiety 8% vs 2% [21]. On lisdexamfetamine in binge eating disorder, dry mouth was 36% vs 7% and feeling jittery 6% vs 1% [18]. Pooled across trials, any adverse event was more frequent on methylphenidate than placebo in children (RR 1.23, 95% CI 1.11 to 1.37) and adults (RR 1.27, 95% CI 1.19 to 1.37), and adults on amphetamines withdrew for adverse events more often (RR 2.69, 95% CI 1.63 to 4.45) [2][5][4].
- Population
- Children, adolescents and adults in label trials [17][21][18]; 5,342 children in 35 trials [2]; 4,214 adults in 14 trials [5]; 2,409 adults in 17 studies [4].
- Sources
- [17], [21], [18], [2], [5], [4]
- Caveats
- Serious adverse events did not differ from placebo in the pooled methylphenidate trials in children (RR 0.80, 95% CI 0.39 to 1.67) or adults (RR 1.43, 95% CI 0.85 to 2.43), with very low certainty [2][5].
Dry mouth, drowsiness and other side effects
Shown to raise side effects such as dry mouth, drowsiness and dizziness, with any adverse event in 55% to 78% on amitriptyline against 36% to 47% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In depression trials, amitriptyline caused more anticholinergic side effects, fast heart rate, dizziness, nervousness, sedation, tremor, indigestion and sexual dysfunction than placebo, and more people left for side effects (OR 4.15) [1]. In nerve pain trials, at least one adverse event occurred in 55% against 36% [3], and in fibromyalgia trials in 78% against 47% [6]. In the children's migraine trial, fatigue occurred in 30% against 14% and dry mouth in 25% against 12% [8].
- Population
- 3,509 adults in depression trials [1]; 1,342 adults with nerve pain [3]; 649 adults with fibromyalgia [6]; 361 children and adolescents [8].
- Sources
- [1], [3], [6], [8]
- Caveats
- The pain trials used lower doses than depression trials and were small.
Dizziness, nausea and headache
Shown to raise dizziness, in 12% against 3% on placebo across 17 trials, along with nausea, headache and nervousness.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In pooled data from 17 four-week trials: dizziness 12% vs 3% on placebo, nausea 8% vs 5%, headache 6% vs 3%, nervousness 5% vs 1% and lightheadedness 3% vs under 1%. About 10% of 2,200 patients in premarketing anxiety trials stopped for an adverse event [4]. A meta-analysis of 13 trials found higher odds than placebo of dizziness (OR 4.66, 95% CI 2.07 to 10.47), constipation (OR 4.11, 95% CI 1.34 to 12.55) and gastric distress (OR 1.97, 95% CI 1.03 to 3.78) [16]. A second found more nausea and dizziness than placebo [1].
- Population
- 477 patients on buspirone and 464 on placebo in 17 trials [4]; 13 randomized trials reporting side effects [16]; 70 studies of azapirones [1].
- Sources
- [4], [16], [1]
- Caveats
- The label trials lasted 4 weeks.
Gastrointestinal effects and stopping treatment
Shown to raise nausea and diarrhea, with about 3 times the odds of stopping for side effects as on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Mild or moderate nausea and diarrhea were the most frequent adverse events. Serious events occurred in 6.2% on liraglutide and 5.0% on placebo [1]. In adolescents, gastrointestinal events occurred in 64.8% on liraglutide and 36.5% on placebo, and events leading to discontinuation in 10.4% and 0% [4]. Across trials, liraglutide had odds of stopping for adverse events 2.95 times (95% CrI 2.11 to 4.23) those of placebo [2].
- Population
- Trial participants in [1], [2] and [4].
- Sources
- [1], [2], [4]
- Caveats
- In LEADER, gastrointestinal events were the most common reason for stopping [9].
Gut side effects in women with PCOS
Shown to raise gut side effects in women with PCOS, from 10% on placebo to between 22% and 40% on metformin.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Against placebo, gastrointestinal side effects rose from 10% to between 22% and 40% (OR 4.00, 95% CI 2.63 to 6.09, 7 studies, 713 women, moderate quality) [30]. A second review found more mild gastrointestinal adverse effects on metformin than placebo (OR 7.67, 95% CI 2.74 to 21.46) [34]. Against combined oral contraceptive pills, metformin may raise severe gastrointestinal adverse events (Peto OR 6.42, 95% CI 2.98 to 13.84, 11 RCTs, 602 women) and lower other severe adverse events (Peto OR 0.20, 95% CI 0.09 to 0.44) [36].
- Population
- Women with PCOS and subfertility [30]; RCTs in women with PCOS published through July 2022 [34]; 44 RCTs with 2,253 women and adolescents with PCOS [36].
- Sources
- [30], [34], [36]
- Caveats
- The comparison with the pill rests on low-quality evidence [36].
Increased appetite and weight gain
Shown to cause increased appetite in 17% against 2% on placebo, and a weight gain of 7% or more in 7.5% against 0.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In US controlled trials, increased appetite was reported by 17% on mirtazapine and 2% on placebo, weight gain as an adverse reaction by 12% against 2%, and a gain of 7% or more of body weight by 7.5% against 0. In premarketing studies that included long-term open-label treatment, 8% stopped because of weight gain. In an 8-week pediatric trial, 49% gained at least 7% against 5.7% on placebo [7]. Mirtazapine was more likely than SSRIs to cause weight gain or increased appetite [2].
- Population
- 453 adults on mirtazapine and 361 on placebo in 6-week trials, and children in an 8-week trial [7]; 2,626 participants in 12 trials against SSRIs [2].
- Sources
- [7], [2]
- Caveats
- Six-week trials, so longer-term weight change is not measured here. Mirtazapine is not approved for children.
Nausea and other gastrointestinal effects
Shown to raise nausea to about 27 to 30% against 5% on placebo, with more headache, constipation, dizziness, vomiting and dry mouth.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Nausea occurred in 29.8% on naltrexone 32 mg with bupropion, 27.2% on naltrexone 16 mg with bupropion and 5.3% on placebo. Headache, constipation, dizziness, vomiting and dry mouth were also more frequent than on placebo [1]. In type 2 diabetes, nausea occurred in 42.3% against 7.1%, vomiting in 18.3% against 3.6% and constipation in 17.7% against 7.1% [5]. In the cardiovascular trial, gastrointestinal events occurred in 14.2% against 1.9% [6].
- Population
- Trial participants in [1], [5] and [6].
- Sources
- [1], [5], [6]
- Caveats
- Rates differ across trials with how events were collected.
Constipation, nausea, drowsiness and other common effects
Shown to raise side effects, with any adverse event in 22% against 15% on placebo in osteoarthritis trials and vomiting in 5.9% against 2.3%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- An overview of 14 Cochrane reviews found opioids raised the risk of any adverse event against placebo (RR 1.42, 95% CI 1.22 to 1.66) and of a serious adverse event (RR 2.75, 95% CI 2.06 to 3.67), with constipation, dizziness, drowsiness, fatigue, hot flushes, sweating, nausea, itching and vomiting each more frequent [22]. In osteoarthritis trials, any adverse event was reported by 22% on opioids and 15% on control (RR 1.49, 95% CI 1.35 to 1.63) [9]. In chronic pain trials that excluded people with adverse events during a run-in, vomiting occurred in 5.9% against 2.3% [6]. In tramadol trials in chronic pain, the label reports constipation in 24% within 7 days and 46% within 90 days, nausea in 24% and 40%, and dizziness in 26% and 33% [16].
- Population
- 18,679 participants in 61 studies lasting 2 weeks to 13 months [22]; 8,275 people in 22 osteoarthritis trials [9]; 26,169 participants in 96 trials [6]; 427 people in tramadol trials [16].
- Sources
- [22], [9], [6], [16]
- Caveats
- The tramadol label figures have no placebo comparison. None of the Cochrane reviews reported addiction, hormone effects, breathing depression or sleep apnea [22].
Oily stools, urgency and fecal incontinence
Shown to raise oily spotting to 27% against 1% on placebo, with more fecal urgency, oily stools and incontinence.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the Xenical year-one trials, oily spotting occurred in 27% on orlistat and 1% on placebo. Flatus with discharge occurred in 24% against 1%, fecal urgency in 22% against 7%, fatty or oily stool in 20% against 3%, and fecal incontinence in 8% against 1% [9]. Pooled, gastrointestinal events were more common than on placebo (RR 1.46, 95% CI 1.37 to 1.55) [5].
- Population
- 1,913 on orlistat and 1,466 on placebo in seven 1- to 2-year trials [9]; 17 trials [5].
- Sources
- [9], [5]
- Caveats
- The label states these events may increase with a diet above 30% of calories from fat [9].
Nausea, low appetite and stomach pain
Shown to raise nausea in adults to 26% on atomoxetine against 6%, and low appetite in children to 16% against 4%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In children on atomoxetine, decreased appetite occurred in 16% against 4% on placebo, abdominal pain 18% against 10%, vomiting 11% against 6% and nausea 10% against 5%. In adults, nausea occurred in 26% against 6%, dry mouth 20% against 5%, decreased appetite 16% against 3% and constipation 8% against 3% [9]. On viloxazine, decreased appetite occurred in 7% of children against 0.4%, and nausea in 12% of adults against 3% [6].
- Population
- 1,597 children on atomoxetine and 934 on placebo; 1,697 adults on atomoxetine and 1,560 on placebo [9]; viloxazine label trials [6].
- Sources
- [9], [6]
- Caveats
- Trials of up to 18 weeks in children and 25 weeks in adults [9].
Dry mouth, constipation and dizziness
Shown to cause dry mouth in 44% on quetiapine against 13% on placebo in bipolar depression trials, with constipation and dizziness also more frequent.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In 8-week bipolar depression trials of quetiapine: dry mouth 44% vs 13% on placebo, dizziness 18% vs 7%, constipation 10% vs 4% and fatigue 10% vs 8%. In schizophrenia and mania trials: dry mouth 9% vs 3%, constipation 8% vs 3%, dizziness 11% vs 5% and tachycardia 6% vs 4% [3].
- Population
- 698 people on quetiapine and 347 on placebo in bipolar depression trials, and 719 and 404 in schizophrenia and mania trials [3].
- Sources
- [3]
- Caveats
- The evidence is for quetiapine.
157 more
Symptoms after stopping
Shown to cause one or more discontinuation symptoms in 12.1% after abruptly stopping extended-release quetiapine, against 6.7% after stopping placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In short-term trials with a discontinuation phase, one or more symptoms after abrupt stopping were reported by 12.1% (241 of 1,993) on extended-release quetiapine and 6.7% (71 of 1,065) on placebo. The label names insomnia, nausea and vomiting as acute withdrawal symptoms described after abrupt cessation of atypical antipsychotics [3].
- Population
- 1,993 people stopping extended-release quetiapine and 1,065 stopping placebo [3].
- Sources
- [3]
- Caveats
- The evidence is for quetiapine after short-term use. No study of misuse or dependence was sourced for this page.
Gastrointestinal effects
Gastrointestinal side effects ran 2% to 23% on berberine against 2% to 15% on placebo, with no serious adverse events reported in 16 trials.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In one diabetes trial, 34.5% of patients had transient gastrointestinal side effects, with no liver or kidney damage found [5]. Across lipid trials, gastrointestinal events were 2% to 23% with berberine and 2% to 15% with placebo, and no serious adverse events were reported in 16 trials [8]. In diabetes trials, total adverse events were lower with berberine (RR 0.73, 95% CI 0.55 to 0.97), and hypoglycemia did not differ (RR 0.48, 95% CI 0.21 to 1.08) [1].
- Population
- Trial participants [1][5][8].
- Sources
- [1], [5], [8]
- Caveats
- Trials ran up to 24 weeks.
Nausea, flushing and headache
Shown to raise nausea to 40% against 1.3% on placebo, along with flushing, headache and vomiting. Most events were mild to moderate and passed.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the controlled trials, nausea occurred in 40.0% on bremelanotide and 1.3% on placebo, flushing in 20.3% against 0.3%, injection site reactions in 13.2% against 8.4%, headache in 11.3% against 1.9%, and vomiting in 4.8% against 0.2%. Nausea needed anti-nausea medication in 13% [2]. In the 52-week open-label extension, drug-related nausea occurred in 40.4%, flushing in 20.6% and headache in 12.0% [4].
- Population
- 627 women on bremelanotide and 620 on placebo [2]; 684 women in the extension [4].
- Sources
- [2], [4]
- Caveats
- The label reports most events as mild to moderate and transient, and nausea improved for most people with the second dose [2]. The extension had no comparison group [4].
Stopping because of side effects
Shown to raise stopping for side effects to 18% against 2% on placebo, most often because of nausea.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Adverse reactions led 18% on bremelanotide and 2% on placebo to stop, most often nausea (8%). Serious adverse reactions occurred in 1.1% against 0.5% [2]. 70% of the bremelanotide group continued into the open-label phase, against 87% of the placebo group [5].
- Population
- 1,247 women in the controlled trials [2][5].
- Sources
- [2], [5]
- Caveats
- In the extension, 272 of 684 women completed 52 weeks [4].
Dry mouth, nausea and other common side effects
Shown to raise dry mouth, nausea, dizziness, tremor, sweating and ringing in the ears against placebo, with dry mouth in 17% to 24% against 7%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In depression trials at 300 and 400 mg a day against placebo: dry mouth 17% and 24% vs 7%, nausea 13% and 18% vs 8%, dizziness 7% and 11% vs 5%, tremor 6% and 3% vs 1%, sweating 6% and 5% vs 2%, tinnitus 6% and 6% vs 2%, anxiety 5% and 6% vs 3% and agitation 3% and 9% vs 2% [15]. In smoking cessation trials, more people dropped out for adverse events on bupropion than on placebo (RR 1.44, 95% CI 1.27 to 1.65) [4]. In veterans with depression, anxiety was reported by 22.5% to 24.3% in the bupropion groups against 16.6% on added aripiprazole [10].
- Population
- 490 adults on sustained-release bupropion and 385 on placebo [15]; 12,346 participants in 25 smoking cessation studies [4]; 1,522 veterans [10].
- Sources
- [15], [4], [10]
- Caveats
- Short-term trials. Several effects were more frequent at 400 mg than at 300 mg a day [15].
Other adverse events in trials
Shown to raise diarrhea, vomiting, fatigue, sleepiness and loss of appetite in seizure trials, with 14% against 1% withdrawing for side effects.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the Lennox-Gastaut trial, adverse events occurred in 86% on CBD and 69% on placebo, and 14% vs 1% withdrew because of them [3]. Diarrhea, vomiting, fatigue, fever, somnolence and decreased appetite were more frequent with CBD [1][3].
- Population
- Patients with Dravet or Lennox-Gastaut syndrome [1][3]. Healthy adults [15].
- Sources
- [1], [3], [15]
- Caveats
- These patients took several other antiepileptic drugs. In 4 RCTs of 269 healthy adults, diarrhea was more likely on CBD than placebo (RR 5.85, 95% CI 1.14 to 30.02). Headache, abdominal pain, fatigue and dizziness did not differ significantly [15].
Nausea, vomiting and diarrhea
Shown to raise stomach side effects, with nausea in 21% on 1.5 mg against 5% on placebo and vomiting in 13% against 2%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In pooled placebo-controlled trials, nausea occurred in 21.1% on 1.5 mg, 12.4% on 0.75 mg and 5.3% on placebo, vomiting in 12.7%, 6.0% and 2.3%, diarrhea in 12.6%, 8.9% and 6.7%, abdominal pain in 9.4%, 6.5% and 4.9%, and decreased appetite in 8.6%, 4.9% and 1.6%. Any gastrointestinal reaction occurred in 41%, 32% and 21%, and 3.5%, 1.3% and 0.2% stopped because of one. Severe gastrointestinal reactions occurred in 4.3%, 2.2% and 1.4% [1]. In REWIND, 47.4% on dulaglutide and 34.1% on placebo reported a gastrointestinal adverse event [6].
- Population
- 1,670 adults on dulaglutide and 568 on placebo, mean exposure 23.8 weeks [1]; 9,901 adults [6].
- Sources
- [1], [6]
- Caveats
- The label advises against use in people with severe gastroparesis [1].
Insomnia, jitteriness and gut upset
Shown to raise the odds of insomnia fivefold and jitteriness 3.5-fold against controls, in pooled studies, with insomnia reported by about a quarter of adult drinkers.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Energy drinks raised the odds of insomnia (OR 5.02, 95% CI 1.72 to 14.63) and jitteriness or activeness (OR 3.52, 95% CI 1.28 to 9.67) against control groups. In adults the most reported adverse events were jitteriness, restlessness or shaking hands (29.8%), insomnia (24.7%) and gut upset (21.6%). In children they were insomnia (35.4%), stress (35.4%) and depressed mood (23.1%) [11].
- Population
- 96,549 people in 32 clinical studies [11].
- Sources
- [11]
- Caveats
- The percentages are shares of drinkers reporting each event, without a matched control rate for each [11].
Dizziness, nausea and vertigo
Shown to raise dizziness to 29% against 8%, nausea to 28% against 9%, and vertigo to 23% against 3% in esketamine trials.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- On esketamine with an oral antidepressant, dizziness occurred in 29% vs 8% on placebo, nausea 28% vs 9%, vertigo 23% vs 3%, numbness 18% vs 2%, anxiety 13% vs 6%, vomiting 9% vs 2% and feeling drunk 5% vs 0.5%. 4.6% of adults under 65 stopped for adverse reactions against 1.4% on placebo [4].
- Population
- 346 on esketamine and 222 on placebo [4].
- Sources
- [4]
- Caveats
- Effects mostly occur on treatment days.
Dizziness, double vision, unsteadiness, nausea and sleepiness in epilepsy trials
Shown to raise dizziness, double vision, unsteadiness and nausea when added to other seizure drugs, with dizziness in 38% against 13% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In pooled add-on epilepsy trials, dizziness occurred in 38% on lamotrigine and 13% on placebo, headache 29% and 19%, double vision 28% and 7%, unsteadiness (ataxia) 22% and 6%, nausea 19% and 10%, blurred vision 16% and 5%, sleepiness 14% and 7%, and vomiting 9% and 4%. Dizziness, double vision, ataxia, blurred vision, nausea and vomiting rose with dose [4]. In a Cochrane review the risk ratios were 3.34 for ataxia, 1.76 for dizziness, 1.81 for nausea and 3.79 for double vision, with no difference in fatigue (RR 0.82) [7].
- Population
- 711 adults on lamotrigine and 419 on placebo, added to 1 to 3 other seizure drugs [4]; 14 trials with 1,806 participants [7].
- Sources
- [4], [7]
- Caveats
- These trials added lamotrigine to other seizure drugs, which raises these effects. Rates were lower in the bipolar trials, where it was taken alone [4].
Side effects in bipolar trials
Shown to raise nausea, insomnia, fatigue and back pain slightly in bipolar trials, with nausea in 14% against 11% on placebo. Overall adverse effects matched placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In two 18-month bipolar trials, nausea occurred in 14% on lamotrigine and 11% on placebo, insomnia 10% and 6%, sleepiness 9% and 7%, back pain 8% and 6%, fatigue 8% and 5%, and dry mouth 6% and 4%. 13% stopped lamotrigine for an adverse reaction, against 16% on placebo and 23% on lithium [4]. A Cochrane review found the share with any adverse effect similar to placebo over 6 to 12 months (RR 0.97, 95% CI 0.77 to 1.23) [1].
- Population
- 227 adults on lamotrigine, 190 on placebo and 166 on lithium [4]; 756 participants in 4 studies [1].
- Sources
- [4], [1]
- Caveats
- During the open-label dose escalation, before randomization, headache (25%), rash (11%) and dizziness (10%) were more frequent [4].
Adverse events in trials
Shown to raise vivid dreams about 2.4 times over placebo, with adverse events overall 1.4 times as frequent. Serious adverse events did not differ.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Vivid dreams were more common on LDN than placebo (RR 2.41, 95% CI 1.77 to 3.28), and headache did not differ [2]. Another meta-analysis found more vivid dreams and nausea, with no difference in serious adverse events, headache, diarrhea or dizziness [1]. Across chronic pain trials, adverse events were 1.4 times as frequent as on placebo (IRR 1.4, 95% CI 1.12 to 1.75) [6]. In the 12-month trial, adverse events occurred in 68.8% on LDN and 72% on placebo, with no treatment-related serious events [5]. In Crohn's disease, withdrawals and specific adverse events did not differ [9].
- Population
- Trial participants with fibromyalgia, chronic pain, Crohn's disease [1][2][5][6][9].
- Sources
- [1], [2], [5], [6], [9]
- Caveats
- Most trials were small and lasted under 4 months.
Diarrhea and other gut effects
Diarrhea and other gut effects were reported in 11 to 37% on oral magnesium against 10 to 14% on control in cramp trials.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Across cramp trials, oral magnesium was linked mainly to gastrointestinal effects such as diarrhea, reported in 11% (10% on control) to 37% (14% on control) of participants. Minor adverse events were more frequent than placebo (RR 1.51, 95% CI 0.98 to 2.33, low certainty). Major adverse events were 2 of 72 on magnesium and 3 of 68 on placebo [10].
- Population
- Pooled cramp RCTs [10].
- Sources
- [10]
- Caveats
- Adverse event counts come from small trials.
Dry mouth, constipation and dizziness
Shown to cause dry mouth in 25% against 15% on placebo, constipation in 13% against 7% and dizziness in 7% against 3%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In 6-week US trials: dry mouth 25% vs 15% on placebo, constipation 13% vs 7%, asthenia 8% vs 5%, dizziness 7% vs 3% and peripheral edema 2% vs 1% [7].
- Population
- 453 adults on mirtazapine and 361 on placebo [7].
- Sources
- [7]
- Caveats
- Six-week trials at 5 to 60 mg a day.
Nausea and other common side effects
Shown to raise nausea, 11% on modafinil against 3% on placebo, along with smaller rises in appetite loss, dry mouth and diarrhea. 8% stopped for side effects.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In pooled trials, nausea occurred in 11% vs 3% on placebo, anorexia in 4% vs 1%, dry mouth in 4% vs 2%, diarrhea in 6% vs 5% and dizziness in 5% vs 4%. 8% stopped modafinil for an adverse reaction against 3% on placebo [3]. On armodafinil, nausea occurred in 7% vs 3% and dizziness in 5% vs 2%, and 7% stopped against 4% [6].
- Population
- 934 on modafinil and 567 on placebo [3]; 645 on armodafinil and 445 on placebo [6].
- Sources
- [3], [6]
- Caveats
- Short trials in people with sleep disorders.
Headache, stomach upset and other common side effects
Shown in label trials to cause side effects at rates close to placebo, with headache in 18.4% on montelukast against 18.1% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In adult and adolescent asthma trials, rates on montelukast 10 mg and placebo were headache 18.4% and 18.1%, influenza 4.2% and 3.9%, abdominal pain 2.9% and 2.5%, dyspepsia 2.1% and 1.1%, dizziness 1.9% and 1.4%, and raised ALT 2.1% and 2.0% [1].
- Population
- 1,955 people on montelukast and 1,180 on placebo aged 15 and older [1].
- Sources
- [1]
- Caveats
- The label lists events regardless of cause, and most differ little from placebo [1].
Side effects when taken for period pain
Shown to raise side effects in women taking NSAIDs for period pain, from 10% on placebo to between 11% and 14%, mostly gut and nervous system effects.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Against placebo, overall adverse effects rose (OR 1.29, 95% CI 1.11 to 1.51, 25 RCTs, low-quality evidence), as did gastrointestinal effects (OR 1.58, 95% CI 1.12 to 2.23, 14 RCTs) and neurological effects (OR 2.74, 95% CI 1.66 to 4.53, 7 RCTs). If 10% of women on placebo had side effects, 11% to 14% on NSAIDs would [24].
- Population
- Women with primary dysmenorrhea in RCTs of NSAIDs against placebo [24].
- Sources
- [24]
- Caveats
- Short courses taken during periods. Evidence quality was low [24].
Fatigue, constipation and diarrhea
Shown to raise fatigue and constipation against placebo in chemotherapy trials, with fatigue in 13% against 2% and constipation in 9% against under 1%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In chemotherapy trials, malaise or fatigue occurred in 13% on ondansetron and 2% on placebo, constipation in 9% and under 1%, and diarrhea in 6% and 4%. Extrapyramidal reactions occurred in under 1% [3]. The label states repeated dosing slowed colonic transit in healthy people [3].
- Population
- 242 adults on ondansetron and 262 on placebo [3].
- Sources
- [3]
- Caveats
- Patients were also receiving chemotherapy, which causes some of these effects.
Gastrointestinal effects and stopping treatment
Shown to raise gut side effects to about 60 to 69% against 37% on placebo, with 8% stopping for side effects against 3%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the label's pool of the two weight trials, gastrointestinal adverse reactions occurred in 60% on 5.5 mg, 68% on 9 mg and 69% on 17.2 mg, against 37% on placebo. Nausea occurred in 26 to 35% against 10%, and vomiting in 13 to 24% against 4%. Adverse reactions led to permanent discontinuation in 8% against 3% [6]. In ATTAIN-1, adverse events led to discontinuation in 5.3 to 10.3% against 2.7% on placebo [1]. Against oral semaglutide, gastrointestinal events occurred in 58 to 59% against 37 to 45%, and discontinuation for adverse events in 9 to 10% against 4 to 5% [8]. A network meta-analysis placed orforglipron among the six obesity drugs with the most discontinuation for adverse events, with moderate to high certainty (risk ratios 1.9 to 4.2 for that group), and among the four with the largest rise in gastrointestinal events (risk ratios 3.1 to 4.2) [3].
- Population
- 3,155 adults on orforglipron and 1,576 on placebo in the label pool [6]; 3,127 adults [1]; 1,698 adults [8]; 262 trials [3].
- Sources
- [6], [1], [8], [3]
- Caveats
- Most events were mild to moderate and occurred mainly during dose escalation [1][6].
Headache, diarrhea and other common side effects
Shown in label trials to raise headache, diarrhea and dizziness against placebo, with headache in 12.2% on pantoprazole against 8.5% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In GERD trials, pantoprazole and placebo rates were headache 12.2% and 8.5%, diarrhea 8.8% and 4.9%, vomiting 4.3% and 2.4%, dizziness 3.0% and 1.2%, and joint pain 2.8% and 1.2%. Nausea (7.0% and 9.8%) and abdominal pain (6.2% and 6.1%) were not higher on the drug [3]. In esomeprazole healing trials, headache occurred in 5.5% on 20 mg, 5% on 40 mg and 3.8% on omeprazole 20 mg [7].
- Population
- 1,473 adults on pantoprazole and 82 on placebo in nine US trials [3]; 6,682 adults in four esomeprazole trials [7].
- Sources
- [3], [7]
- Caveats
- The placebo group in the pantoprazole trials was small (82 people) [3]. The esomeprazole trials had no placebo group [7].
Small intestinal bacterial overgrowth
Linked to about twice the odds of small intestinal bacterial overgrowth, found in 36.8% of users studied against 19.9% of controls, rising with longer use.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Pooled prevalence of bacterial overgrowth was 36.8% (95% CI 29.7 to 44.3) in proton pump inhibitor users and 19.9% in controls (OR 2.14, 95% CI 1.45 to 3.18), with high heterogeneity (I² 77.6%). Each extra month of treatment was associated with about a 4.3 percentage point higher prevalence [34].
- Population
- 29 studies with 3,682 users and 2,907 controls [34].
- Sources
- [34]
- Caveats
- Observational studies. The band above is the prevalence in the people studied, not a rate in all users [34].
Gastrointestinal effects
Shown to raise diarrhea and nausea, the most common side effects, more at higher doses. In diabetes, diarrhea reached 34% against 13% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Gastrointestinal events were the most common adverse events in every trial [1][2][5][6]. In people with diabetes, diarrhea occurred in 27%, 34% and 34% on 4, 9 and 12 mg against 13% on placebo, and nausea in 14%, 21% and 28% against 8% [5]. In phase 2 these events were dose-related and mostly mild to moderate [2].
- Population
- Trial participants in [1], [2], [5] and [6].
- Sources
- [1], [2], [5], [6]
- Caveats
- TRANSCEND-T2D-1 reports the events as subsiding over time [6].
Gastrointestinal effects and stopping treatment
Shown to raise nausea and diarrhea, mostly mild to moderate. Stopping for stomach effects was 4.5% against 0.8% on placebo in one trial.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Nausea and diarrhea were the most common adverse events, mostly mild to moderate. Discontinuation for gastrointestinal events was 4.5% on semaglutide and 0.8% on placebo [1]. In the withdrawal trial, gastrointestinal events occurred in 49.1% on continued semaglutide and 26.1% on placebo [4]. In SELECT, adverse events led to permanent discontinuation in 16.6% on semaglutide and 8.2% on placebo [5]. Gastrointestinal adverse events were more common on semaglutide in ESSENCE [7]. In FLOW, serious adverse events were reported in 49.6% on semaglutide and 53.8% on placebo [6]. In STEP UP, gastrointestinal adverse events occurred in 70.8% on 7.2 mg, 61.2% on 2.4 mg and 42.8% on placebo, and serious adverse events in 6.8%, 10.9% and 5.5% [3].
- Population
- Trial participants in [1], [3], [4], [5], [6] and [7].
- Sources
- [1], [3], [4], [5], [6], [7]
- Caveats
- STEP 1 describes the gastrointestinal events as typically transient and easing with time [1].
Nausea and other common side effects
Shown to raise nausea, dry mouth, sweating, constipation and dizziness against placebo, with nausea in 23% to 30% against 8% to 12% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In pooled duloxetine trials: nausea 23% vs 8% on placebo, dry mouth 13% vs 5%, constipation 9% vs 4%, dizziness 9% vs 5%, fatigue 9% vs 5%, decreased appetite 7% vs 2% and sweating 6% vs 1% [18]. In pooled venlafaxine extended release trials: nausea 30.0% vs 11.8%, dizziness 15.8% vs 9.5%, dry mouth 14.8% vs 5.3%, sweating 11.4% vs 2.9%, loss of appetite 9.8% vs 2.6% and constipation 9.3% vs 3.4% [10]. On desvenlafaxine, nausea rose with dose, from 22% at 50 mg to 41% at 400 mg, against 10% on placebo [9]. In pain trials, 16% stopped duloxetine for adverse effects [13].
- Population
- 8,100 adults on duloxetine and 5,655 on placebo [18]; 3,558 adults on venlafaxine extended release and 2,197 on placebo in studies up to 12 weeks [10]; adults in short-term desvenlafaxine depression studies [9]; 6,407 participants in 18 pain trials [13].
- Sources
- [18], [10], [9], [13]
- Caveats
- Short-term trials. Several of these effects were dose-dependent [18][9].
Nausea, diarrhea and other common side effects
Shown to raise nausea, diarrhea, tremor and sweating against placebo, with nausea in 26% on sertraline against 12% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In pooled sertraline trials: nausea 26% vs 12% on placebo, diarrhea or loose stools 20% vs 10%, dry mouth 14% vs 9%, fatigue 12% vs 8%, dizziness 12% vs 8%, tremor 9% vs 2%, decreased appetite 7% vs 2% and sweating 7% vs 3%. 12% stopped sertraline for an adverse reaction against 4% on placebo [24]. In fluoxetine depression trials, nausea occurred in 21% vs 9% and anxiety in 12% vs 7% [26]. A meta-analysis of 131 SSRI trials found more serious and non-serious adverse events on SSRIs than placebo [2].
- Population
- 3,066 adults on sertraline and 2,293 on placebo [24]; 1,728 adults on fluoxetine and 975 on placebo in depression trials [26]; 27,422 adults in 131 trials [2].
- Sources
- [24], [26], [2]
- Caveats
- Rates come from trials of 8 to 12 weeks and differ by drug and by condition treated [24].
Tingling, taste change, appetite loss and stomach effects
Shown to cause tingling in about half of people at 100 mg, 51% against 6% on placebo, along with appetite loss, taste change, nausea and diarrhea.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In migraine trials at 100 mg, paresthesia occurred in 51% against 6% on placebo, anorexia in 15% against 6%, nausea in 13% against 8%, diarrhea in 11% against 4%, weight loss in 9% against 1%, and taste change in 8% against 1% (15% at 50 mg). 25% stopped topiramate for an adverse reaction, against 10% on placebo, most often for paresthesia (7%) [3]. In weight loss trials, paresthesia, taste impairment and psychomotor effects were the most common adverse events [7].
- Population
- 386 adults on 100 mg, 235 on 50 mg and 445 on placebo [3]; 6,620 people in weight trials [7].
- Sources
- [3], [7]
- Caveats
- Most of these effects were more frequent during titration than during maintenance [3].
Dry mouth, blurred vision and other common side effects
Shown to raise dry mouth, blurred vision, swelling and fatigue against placebo, with dry mouth in 34% of outpatients against 20% on placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In outpatient depression trials: dry mouth 34% vs 20% on placebo, blurred vision 15% vs 4%, skin condition or edema 7% vs 1%, nasal congestion 6% vs 3% and diarrhea 5% vs 1%. In inpatient trials: dry mouth 15% vs 8%, fatigue 11% vs 4%, nausea or vomiting 10% vs 1% and incoordination 5% vs 0 [12]. In insomnia trials, decreased appetite was more frequent than in control groups (OR 2.81, 95% CI 1.14 to 6.92) [7].
- Population
- 157 outpatients and 142 inpatients on trazodone, 158 and 95 on placebo [12]; 466 participants in 11 insomnia RCTs [7].
- Sources
- [12], [7]
- Caveats
- Small, older trials at depression doses. Rates at the lower doses used for sleep may differ.
Digestive and other side effects (modified Atkins)
Limited evidence: in epilepsy trials, constipation was reported in about 17%, lethargy in 11% and loss of appetite in 12% on the modified Atkins diet.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Across 5 RCTs reporting adverse events, constipation occurred in 17% (95% CI 5% to 44%), lethargy in 11% and anorexia in 12% [1]. In children, treatment-related adverse events occurred in 56.9% on the modified Atkins diet and 56.4% on the classic ketogenic diet [5]. Gastrointestinal and lipid side effects did not differ between the two diets in a 2026 meta-analysis [6].
- Population
- Children and adults with drug-resistant epilepsy [1][5][6].
- Sources
- [1], [5], [6]
- Caveats
- Pooled rates from the diet arms, not differences from control.
Nausea and diarrhea
Limited evidence: in people with cirrhosis, nausea and diarrhea occurred in 12% on BCAAs against 3% on control, with a very uncertain estimate.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In a Cochrane review of trials in liver disease, nausea and diarrhea, counted as serious adverse events, occurred in 58 of 477 people (12%) on BCAAs and 16 of 538 (3%) on control diets. The pooled estimate was very uncertain (RR 2.05, 95% CI 0.40 to 10.58) [11].
- Population
- 1,015 participants in 6 trials of people with cirrhosis and hepatic encephalopathy [11].
- Sources
- [11]
- Caveats
- Certainty was very low. Ten of the review's 18 trials gave BCAAs by mouth and eight intravenously [11]. People with cirrhosis are not the population taking BCAAs for training.
Nausea and diarrhea
One small trial found mild nausea or diarrhea in 7 of 52 patients during coumarin, which stopped after the first month.
The numbers and sources
Reduced levothyroxine absorption
Limited evidence: in 20 adults on levothyroxine, 1,200 mg of calcium carbonate lowered free T4 and raised TSH, which returned after stopping calcium.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Taking 1,200 mg of calcium as carbonate with levothyroxine for 3 months lowered free T4 from 17 to 15 pmol/L and raised TSH from 1.6 to 2.7 mIU/L. Both returned after calcium stopped. 20% of patients had TSH above the normal range on calcium [15].
- Population
- 20 adults with hypothyroidism on stable levothyroxine [15].
- Sources
- [15]
- Caveats
- A small uncontrolled cohort, with lab data showing T4 binds to calcium carbonate in acid [15].
Dry mouth, dizziness and constipation
The clonidine tablet label reports dry mouth in about 40 of 100 people, dizziness in 16 and constipation in 10, mostly dose-related and easing over time.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- The most frequent effects on clonidine tablets were dry mouth (about 40 in 100), drowsiness (about 33), dizziness (about 16), and constipation and sedation (about 10 each), mostly dose-related [13]. In children with ADHD, dry mouth occurred in 5% on 0.4 mg against 1% and constipation in 6% against 0% [6].
- Population
- Adults on clonidine tablets [13]; children and adolescents on extended-release clonidine [6].
- Sources
- [13], [6]
- Caveats
- The tablet label gives no placebo rates.
Discomfort during bowel preparation
Mixed results: a trial found more adverse effects with colon hydrotherapy than with a drinkable preparation, and a retrospective study found fewer.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In a 196-person trial, adverse effects were fewer with the polyethylene glycol solution than with colon hydrotherapy [2]. In a retrospective study of salvage preparation, adverse effects occurred in 36.4% after hydrotherapy and 88.9% after a second oral preparation [3]. One uncontrolled study of 28 people recorded no adverse events within 30 days [4].
- Population
- 196 outpatients [2]. 109 patients [3]. 28 patients [4].
- Sources
- [2], [3], [4]
- Caveats
- The abstracts do not list which effects occurred.
Indigestion and stomach upset on dabigatran
One trial found gut side effects such as indigestion and gastritis-like symptoms in 35% on dabigatran 150 mg against 24% on warfarin.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the pivotal atrial fibrillation trial, gastrointestinal adverse reactions were reported by 35% on dabigatran 150 mg against 24% on warfarin, commonly dyspepsia and gastritis-like symptoms including reflux, esophagitis and erosive gastritis. Adverse reactions led 21% on dabigatran and 16% on warfarin to stop treatment [20].
- Population
- 18,113 patients with atrial fibrillation [3][20].
- Sources
- [20], [3]
- Caveats
- The evidence is for dabigatran, against warfarin.
- Why limited
- This rests on one trial, of 18,113 people. Strength counts independent studies that agree, so one trial is limited at any size.
Adverse effects with dasatinib plus quercetin
Small trials found more adverse events on dasatinib plus quercetin, 82% against 43% on placebo in one, all self-limiting.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Adverse events occurred in 82% on dasatinib plus quercetin and 43% on placebo. All were self-limiting [2]. In idiopathic pulmonary fibrosis, one serious adverse event was reported. The most frequent other events were respiratory symptoms (16 events), skin irritation or bruising (14) and gastrointestinal discomfort (12) [5]. No serious adverse events occurred in the bone trial [13]. Across 6 human studies, reported events were generally mild or manageable [3].
- Population
- 31 adults with MASH [2]; 14 adults with pulmonary fibrosis [5]; 60 postmenopausal women [13]; 6 studies [3].
- Sources
- [2], [5], [13], [3]
- Caveats
- Small samples and short follow-up limit the detection of uncommon or long-term harms [3].
Advanced colorectal adenomas
One trial found advanced colorectal lesions in 11.6% on 1 mg a day against 6.9% on placebo, in people with past adenomas.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- At the second colonoscopy, at least one advanced lesion was found in 11.6% on 1 mg folic acid a day and 6.9% on placebo (RR 1.67, 95% CI 1.00 to 2.80). Adenomas of any kind did not differ. Three or more adenomas and noncolorectal cancers were more common on folic acid [19].
- Population
- 1,021 people with a recent history of colorectal adenomas, with colonoscopies at 3 years and again 3 or 5 years later [19].
- Sources
- [19]
- Caveats
- One trial. Only 59.5% had the second colonoscopy [19].
- Why limited
- This rests on one trial, of 1,021 people. Strength counts independent studies that agree, so one trial is limited at any size.
Digestive side effects
Limited evidence: gastrointestinal problems were the most common side effect in children treated for epilepsy, reported in 40.6% across 45 studies.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Across 45 prospective studies, gastrointestinal disturbances were reported in 40.6% of children, hyperlipidemia in 12.8% and high uric acid in 4.4%. Severe events such as respiratory failure and pancreatitis occurred in no more than 0.5% [17]. In Cochrane trials, vomiting, constipation and diarrhea were the most common adverse effects in both diet and usual care groups [8]. Serious adverse events were rare in 14 RCTs [9].
- Population
- Children with drug-resistant epilepsy [8][9][17].
- Sources
- [8], [9], [17]
- Caveats
- Mostly uncontrolled studies. Certainty for adverse effects in the Cochrane review was low to very low [8].
Acid symptoms after stopping (rebound)
One trial found 44% of healthy volunteers had acid-related symptoms after stopping 8 weeks of a proton pump inhibitor, against 15% after placebo.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- Volunteers took 8 weeks of esomeprazole 40 mg a day and then 4 weeks of placebo, or 12 weeks of placebo. In weeks 9 to 12, 44% (26 of 59) of the drug group and 15% (9 of 59) of the placebo group reported at least one relevant acid-related symptom. Heartburn, dyspepsia or regurgitation was reported by 22% against 5% at week 11 [35].
- Population
- 120 healthy volunteers, randomized [35].
- Sources
- [35]
- Caveats
- One small trial in people without reflux disease. Rebound may be harder to separate from returning symptoms in people with reflux.
Mouth sores, gut effects and blood count changes
Small trials found mouth sores, rash and gut problems in a few older adults, and falls in red cell counts without clinical effects.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the pilot, adverse effects on rapamycin were a facial rash (1), mouth sores (1) and gastrointestinal problems (2), against mouth sores (1) on placebo. Hemoglobin, hematocrit and red cell count fell on rapamycin, without clinical effects over the study [2]. In LAM, the label lists mouth sores, diarrhea, abdominal pain, nausea, acne and swelling among reactions in 20% or more [8].
- Population
- 25 older adults [2]; LAM patients in the label [8].
- Sources
- [2], [8]
- Caveats
- Small numbers. In PEARL, adverse events did not differ across groups [1].
Stomach discomfort and diarrhea
Limited evidence: stomach discomfort and diarrhea each affected about 1 in 5 on SAMe in one trial. Side effects did not differ significantly from placebo in other trials.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In the 12-week trial, stomach discomfort (19%) and diarrhea (20%) were the most common side effects on SAMe [2]. In osteoarthritis trials, any adverse event did not differ significantly from placebo (RR 1.27, 95% CI 0.94 to 1.71) [6]. In alcoholic liver disease trials, non-serious adverse events did not differ significantly (RR 4.92, 95% CI 0.59 to 40.89) [7].
- Population
- 189 outpatients with depression [2]. 656 people with osteoarthritis [6]. 434 people with liver disease [7].
- Sources
- [2], [6], [7]
- Caveats
- No osteoarthritis trial reported on serious adverse events [6].
Gastrointestinal symptoms
Limited evidence: about 35% reported mild, brief stomach symptoms in small trials without placebo.
The numbers and sources
Diarrhea, nausea and rash
Shown to raise side effects such as diarrhea, vomiting and rash against placebo, one extra person affected for every 8 to 24 treated, depending on the infection.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Against placebo, side effects rose in sinusitis (OR 2.21, one extra per 8 treated) [1], children's ear infections (RR 1.38, one per 14) [7], bronchitis (RR 1.20, one per 24) [4] and colds (RR 1.8) [6]. Nausea, rash or diarrhea was one extra per 21 on amoxicillin [5]. In label trials, diarrhea or loose stools affected 9% on amoxicillin-clavulanate [20], and diarrhea 5% to 14% on azithromycin [18].
- Population
- Trial populations in [1][7][4][6][5]; label trials [20][18].
- Sources
- [1], [7], [4], [6], [5], [20], [18]
- Caveats
- The label rates have no placebo comparison.
Major bleeding on aspirin
Shown to raise major bleeding by about 43% against no aspirin, to 4.1% against 3.2% over 7.4 years in one trial and 3.8% against 2.8% in another.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Across 13 primary prevention trials, aspirin raised major bleeding (HR 1.43, 95% credible interval 1.30 to 1.56, absolute increase 0.47%, number needed to harm 210) [11]. Major gastrointestinal and extracranial bleeds occurred at 0.10% a year on aspirin against 0.07% on control [2]. Major bleeding occurred in 4.1% on aspirin against 3.2% on placebo over a mean 7.4 years in adults with diabetes [14], and major hemorrhage in 3.8% against 2.8% over a median 4.7 years in adults aged 70 or over [16]. The prescription aspirin label states that aspirin increases the risk of bleeding [23].
- Population
- 164,225 participants in 13 trials [11]; 15,480 adults with diabetes [14]; 19,114 adults aged 70 or over [16].
- Sources
- [11], [2], [14], [16], [23]
- Caveats
- The main risk factors for coronary disease were also risk factors for bleeding [2].
Stomach and gut bleeding
Shown to raise stomach and gut bleeding by about 25% against warfarin across the class, with the rise seen on rivaroxaban and not on apixaban.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Across the four atrial fibrillation trials, DOACs increased gastrointestinal bleeding against warfarin (RR 1.25, 95% CI 1.01 to 1.55) [1]. In the rivaroxaban trial, 221 of 7,111 people on rivaroxaban had a gastrointestinal bleed against 140 of 7,125 on warfarin (HR 1.61, 95% CI 1.30 to 1.99) [23]. In the apixaban trial it was 128 of 9,088 against 141 of 9,052 (HR 0.89, 95% CI 0.70 to 1.14) [22]. A network meta-analysis found gastrointestinal bleeding higher with some DOACs than with warfarin [15]. In a cohort of 527,226 users, apixaban was associated with less gastrointestinal bleeding than the other three drugs (HR 0.72 to 0.81) [17].
- Population
- 71,683 participants in four trials [1]; 14,236 people in the rivaroxaban trial [23]; 18,140 in the apixaban trial [22]; 527,226 new users [17].
- Sources
- [1], [23], [22], [15], [17]
- Caveats
- The band above is the 3.1% with a gastrointestinal bleed on rivaroxaban in its trial. The comparator is warfarin.
Gastrointestinal effects and stopping treatment
Shown to raise nausea, vomiting, diarrhea and constipation about threefold over placebo, mostly mild to moderate and early. Stopping for side effects rose at higher doses.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Gastrointestinal events were the most common adverse events, mostly mild to moderate. Adverse events led to discontinuation in 4.3%, 7.1% and 6.2% on 5, 10 and 15 mg, against 2.6% on placebo [1]. In SUMMIT, adverse events, mainly gastrointestinal, led to discontinuation in 6.3% on tirzepatide and 1.4% on placebo [9]. Against dulaglutide, overall adverse event rates looked similar, with more gastrointestinal events on tirzepatide [13]. Pooled against placebo in adults without diabetes, the RR was 3.11 for nausea (95% CI 2.74 to 3.54), 5.94 for vomiting (95% CI 4.50 to 7.85), 2.92 for diarrhea (95% CI 2.53 to 3.37) and 2.85 for constipation (95% CI 2.38 to 3.42). Serious gastrointestinal events (RR 3.07, 95% CI 2.03 to 4.66) and stopping because of adverse events (RR 2.29, 95% CI 1.74 to 3.01) were also more frequent [3]. A second meta-analysis found gastrointestinal events 2.94 times as likely (95% CI 2.61 to 3.32), with no significant rise in biliary, liver or pancreatic events [15]. Across 17 RCTs, permanent discontinuation for any reason was not higher than placebo, while discontinuation for adverse events rose at higher doses [16].
- Population
- Trial participants in [1], [9] and [13]; 6 RCTs [3]; 13 RCTs of semaglutide and tirzepatide in 26,894 adults without diabetes [15]; 14,645 participants in 17 RCTs [16].
- Sources
- [1], [9], [13], [3], [15], [16]
- Caveats
- SURMOUNT-1 reports these events as occurring mainly in the early weeks of treatment [1].
Upper gut irritation with tablets
Mixed results: the alendronate label warns of esophageal irritation and ulcers, while pooled trials found gut side effects about as frequent as on placebo.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- In US and multinational label trials, abdominal pain was 6.6% on alendronate 10 mg and 4.8% on placebo, and esophageal ulcer 1.5% against 0.0%. In the larger Fracture Intervention Trial, abdominal pain was 1.5% in both groups. The label reports esophagitis, ulcers and erosions, rarely with stricture or perforation, more with lying down after a dose [15]. The Cochrane review found alendronate may make little or no difference to gastrointestinal adverse events [1]. In Paget's disease trials, mild gastrointestinal events were 64% against 48% (RR 1.32, 95% CI 0.91 to 1.92) [12].
- Population
- 196 and 3,236 women on alendronate in label trials [15]; trial populations in [1] and [12].
- Sources
- [15], [1], [12]
- Caveats
- Label tables count only events the investigators judged drug related.
Constipation
Shown to cause constipation on verapamil, reported by 7.3% of people in its trials. The label gives no placebo rate.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- In clinical trials of oral verapamil, constipation was the most frequent reaction, in 7.3%, followed by dizziness (3.3%), nausea (2.7%) and low blood pressure (2.5%). The label also notes infrequent reports of reversible paralytic ileus [16].
- Population
- 4,954 people in clinical trials of oral verapamil [16].
- Sources
- [16]
- Caveats
- The evidence is for verapamil, a non-dihydropyridine. No placebo rate is given.
Constipation
Shown to raise constipation to 6% to 8% on atogepant against 2%, and to 3% on erenumab 140 mg against 1%. The erenumab label warns of serious cases.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Constipation occurred in 6% to 8% on atogepant against 2% on placebo [16], and pooled atogepant trials found it more than twice as frequent (RR 2.55, 95% CI 1.91 to 3.41) [5]. On erenumab it occurred in 3% at 140 mg and 1% at 70 mg against 1% [12]. The erenumab label reports constipation with serious complications after approval, some needing hospital care or surgery, mostly after the first dose [12].
- Population
- 1,403 on atogepant and 663 on placebo [16]; 2,813 in 4 atogepant trials [5]; erenumab trials and postmarketing reports [12].
- Sources
- [16], [5], [12]
- Caveats
- The label states drugs that slow the gut may add to the risk [12].
Nausea and tiredness with gepants
Shown to raise nausea on gepants, 9% on atogepant 60 mg against 3%, and 2% to 4% on rimegepant or ubrogepant against under 1% to 2%.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- On atogepant, nausea occurred in 5% to 9% against 3%, fatigue or sleepiness in 4% to 5% against 4%, and decreased appetite in up to 3% [16]. Pooled atogepant trials found nausea (RR 2.19) and fatigue at high doses (RR 3.07) more frequent [5]. On ubrogepant, nausea occurred in 2% to 4% against 2% and sleepiness in 2% to 3% against 1% [15]. In the rimegepant prevention trial, nausea occurred in 2.7% against 0.8% [6]. Adverse events overall after a rimegepant dose were 14.3% against 12.7% (RR 1.14, 95% CI 1.00 to 1.30) [8].
- Population
- Label trials [16][15][6]; 2,813 in atogepant trials [5]; 6,734 in rimegepant trials [8].
- Sources
- [16], [5], [15], [6], [8]
- Caveats
- Short trials.
Bleeding when taken with NSAIDs, aspirin or other blood thinners
Linked to about 2.4 times the major bleeding when an NSAID was taken alongside an anticoagulant, and to 3.1% against 1.9% when rivaroxaban was added to aspirin.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Among people treated for venous clots with rivaroxaban or enoxaparin and a vitamin K antagonist, major bleeding occurred at 6.5 per 100 patient-years during NSAID use against 2.0 without (HR 2.37, 95% CI 1.51 to 3.75), and clinically relevant bleeding at 37.5 against 16.6 (HR 1.77). With aspirin, clinically relevant bleeding occurred at 36.6 against 16.9 per 100 patient-years (HR 1.70, 95% CI 1.38 to 2.11). The increases were similar for both anticoagulant regimens [24]. Adding rivaroxaban to aspirin raised major bleeding to 3.1% against 1.9% on aspirin alone [13]. The labels state that aspirin, other antiplatelet drugs, other anticoagulants and chronic NSAID use increase the risk of bleeding [22][23].
- Population
- 8,246 patients in two rivaroxaban venous thromboembolism trials [24]; 27,395 participants with stable vascular disease [13].
- Sources
- [24], [13], [22], [23]
- Caveats
- The NSAID analysis is observational within trials and gives rates per patient-years. The band above is the share with major bleeding on rivaroxaban plus aspirin [13].
Headache, dizziness and constipation
The labels report headache, dizziness and constipation in 1% or more on famotidine. On cimetidine 1,600 mg a day, headache occurred in 3.5% against 2.3% on placebo.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Headache, dizziness and constipation occurred in 1% or more of 1,442 famotidine-treated patients in 7 trials. The label gives no placebo rate [2]. On cimetidine, headache was reported in 3.5% on 1,600 mg a day, 2.1% on 800 mg a day and 2.3% on placebo. Diarrhea, dizziness and drowsiness were each reported in about 1 in 100 [14].
- Population
- About 2,500 patients in 7 famotidine trials [2]; 924, 2,225 and 1,897 patients on cimetidine 1,600 mg, 800 mg and placebo [14].
- Sources
- [2], [14]
- Caveats
- Only the cimetidine label gives a placebo rate, and only for headache.
Stomach and intestinal bleeding, and use with NSAIDs
Shown to raise gastrointestinal bleeding or perforation, 2.9% against 2.0% on placebo, mainly in hospital patients. Ulcer risk was far higher with an NSAID.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Across 159 trials, gastrointestinal bleeding or perforation occurred in 2.9% on corticosteroids and 2.0% on placebo (OR 1.43, 95% CI 1.22 to 1.66). The rise was significant in hospitalized patients and not in ambulatory care, where 11 events occurred among 8,651 patients (0.13%) [24]. In a case-control study, current oral corticosteroid users who also took NSAIDs had a relative risk of peptic ulcer disease of 4.4 (95% CI 2.0 to 9.7), those not taking NSAIDs 1.1 (95% CI 0.5 to 2.1), and people on both drugs had 15 times the risk of people on neither [25]. The label states that aspirin or other NSAIDs taken with corticosteroids increase the risk of gastrointestinal side effects [20].
- Population
- 33,253 participants in 159 trials [24]; 1,415 people hospitalized for ulcer or upper gastrointestinal bleeding and 7,063 controls in Tennessee Medicaid [25].
- Sources
- [24], [25], [20]
- Caveats
- The pooled trial rate is driven by hospital patients [24]. The NSAID finding is observational, from 1984 to 1986 [25].
Gut infections, including C. difficile
Linked to about 1.7 times the odds of C. difficile infection in observational studies. In a 3-year trial, enteric infections were 1.4% on pantoprazole against 1.0% on placebo.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Across 39 observational studies, proton pump inhibitor use was associated with C. difficile infection (OR 1.74, 95% CI as reported 1.47 to 2.85) and with recurrence (OR 2.51). The odds rose further with antibiotics (OR 1.96 above a proton pump inhibitor alone) [20]. In a randomized trial, enteric infections occurred in 1.4% on pantoprazole and 1.0% on placebo (OR 1.33, 95% CI 1.01 to 1.75). C. difficile infection was about twice as common on pantoprazole, from only 13 events, not statistically significant [19]. The label states observational studies suggest a higher risk of C. difficile diarrhea, especially in hospitalized patients [3].
- Population
- 42 observational studies with about 313,000 participants [20]; 17,598 adults with stable cardiovascular disease followed a median 3 years [19].
- Sources
- [20], [19], [3]
- Caveats
- Heterogeneity was high in the observational analysis (I² 85%) [20]. The trial rate is for all enteric infections, not C. difficile alone [19].
Dizziness, nausea and gut upset
Shown to cause dizziness in 5.0% on glimepiride against 2.4% on placebo and nausea in 5.0% against 3.4%, with diarrhea in 5.4% on glipizide against none.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- In 11 pooled placebo-controlled trials of glimepiride, dizziness was reported by 5.0% against 2.4% on placebo, nausea by 5.0% against 3.4% and headache by 8.2% against 7.8% [3]. In placebo-controlled trials of extended-release glipizide, dizziness was reported by 6.8% against 5.8%, diarrhea by 5.4% against 0%, tremor by 3.6% against 0% and flatulence by 3.2% against 1.4% [13]. In glyburide trials, gut disturbances such as nausea, fullness and heartburn occurred in 1.8% [14].
- Population
- 745 people on glimepiride and 294 on placebo [3]; 278 on extended-release glipizide and 69 on placebo [13].
- Sources
- [3], [13], [14]
- Caveats
- The glipizide placebo group was small, and the glyburide label gives no placebo rate.
Drowsiness, dizziness and other common side effects
Shown to cause drowsiness in 8% against 5% on placebo and dizziness in 5% against 1% in zolpidem trials lasting 28 to 35 nights.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- In US trials of zolpidem up to 10 mg lasting 28 to 35 nights: drowsiness 8% vs 5% on placebo, dizziness 5% vs 1%, drugged feeling 3% vs 0, lethargy 3% vs 1%, dry mouth 3% vs 1% and palpitation 2% vs 0. In trials of up to 10 nights: headache 7% vs 6%, drowsiness 2% vs 0, dizziness 1% vs 0 and diarrhea 1% vs 0. About 4% of 1,701 people in US premarketing trials stopped because of an adverse reaction [13]. In a 6-week eszopiclone trial, somnolence was reported by 10% on 2 mg and 8% on 3 mg against 3% on placebo, dizziness by 5% and 7% against 4%, and headache by 21% and 17% against 13% [7].
- Population
- 152 people on zolpidem and 161 on placebo in three trials of 28 to 35 nights, and 685 and 473 in 11 trials of up to 10 nights [13]; 308 adults in a 6-week eszopiclone trial [7].
- Sources
- [13], [7]
- Caveats
- The label notes a dose relationship for many of these reactions. Rates come from trials of people selected for insomnia without other major illness.
Self-reported symptoms and nutrient concerns
Limited evidence: in a self-report survey, 3.1% to 5.5% reported digestive symptoms, and fewer reported muscle or skin symptoms.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Reported symptoms included gastrointestinal (3.1% to 5.5%), muscular (0.3% to 4.0%) and skin (0.1% to 1.9%) [1].
- Population
- 2,029 survey respondents [1].
- Sources
- [1], [2], [6]
- Caveats
- No study located measured vitamin or mineral levels in people on the diet. A scoping review flagged potential shortfalls in vitamins C and D, calcium, magnesium, iodine and fiber [2]. An analysis of four modeled meal plans, with no people studied, fell short of reference intakes for thiamine, magnesium, calcium and vitamin C, sometimes for iron, folate, iodine and potassium, and well short for fiber [6].
Complications of bowel surgery for deep endometriosis
Case series: after removal of a bowel segment for deep endometriosis, rectovaginal fistula averaged 2.3% to 3.6%, anastomotic leak 1.7% and urinary retention about 5%.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Rectovaginal fistula averaged 3.6% (range 0 to 16.6%) with conventional resection and 2.3% (0 to 10.5%) with nerve-sparing resection. Anastomotic leak averaged 1.7% with both. Urinary retention occurred in 4.5% and 4.9%, and long-term bladder catheterization in 4.9% and 5.6% [17].
- Population
- 7,549 women in 63 studies of segmental bowel resection for colorectal endometriosis [17].
- Sources
- [17]
- Caveats
- Uncontrolled series with inconsistent reporting. This applies to deep bowel disease, not to excision or ablation of superficial lesions [17].
Complications in trials of excision or ablation for milder disease
Limited evidence: trials of excision or ablation for mild disease reported few complications, 3 minor ones among 172 women in the largest.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Four minor complications were reported in the fertility trial, an intestinal bruise, a slight tear of a tube's outer layer, a difficult abdominal inflation and a vascular injury, three in the surgery group and one in the diagnostic group [8]. The laser trial reported no operative complications [2]. The Cochrane review found adverse events poorly reported, with no conversions to open surgery in one trial of 341 women [4].
- Population
- 341 women [8]. 63 women [2]. 14 trials [4].
- Sources
- [8], [2], [4]
- Caveats
- Trials were small and most did not look for adverse events, so rare serious complications cannot be ruled out [4].
Stomach and gut bleeding and ulcers
Shown to about double stomach and gut bleeding on aspirin, 0.97% against 0.46% on placebo over five years in one trial.
The numbers and sources
- How common
- Uncommon: between 1 in 1,000 and 1 in 100 people.
- Effect
- In moderate-risk adults, gastrointestinal bleeding, mostly mild, occurred in 0.97% on aspirin against 0.46% on placebo over a median 60 months (HR 2.11, 95% CI 1.36 to 3.28) [13]. In a head-to-head trial, gastrointestinal hemorrhage occurred in 2.0% on clopidogrel against 2.7% on aspirin, and bleeding needing hospitalization in 0.7% against 1.1% [22]. The prescription aspirin label states that aspirin may cause gastric ulceration and bleeding, with particular risk in people with a history of peptic ulcer [23]. In people on aspirin and clopidogrel, gastrointestinal events occurred in 2.9% on placebo against 1.1% on omeprazole [28].
- Population
- 12,546 moderate-risk adults [13]; 19,185 patients in the clopidogrel against aspirin trial [22][3]; 3,761 patients on both drugs [28].
- Sources
- [13], [22], [3], [23], [28]
- Caveats
- The band above is the 0.97% in the placebo-controlled trial. The head-to-head rates have no placebo group.
Gallbladder disease
Shown to raise gallbladder and bile duct disease about 37% across GLP-1 drug trials. In REWIND, serious acute cholecystitis occurred in 0.5% on dulaglutide against 0.3%.
The numbers and sources
- How common
- Uncommon: between 1 in 1,000 and 1 in 100 people.
- Effect
- In REWIND, gallstones occurred at 0.62 per 100 patient-years on dulaglutide and 0.56 on placebo, and serious acute cholecystitis in 0.5% against 0.3% [1]. Across GLP-1 receptor agonist trials, the relative risk of gallbladder or biliary disease was 1.37 (95% CI 1.23 to 1.52), higher at higher doses and with longer use [11].
- Population
- 9,901 adults in REWIND, as reported in the label [1]; 103,371 patients in 76 trials [11].
- Sources
- [1], [11]
- Caveats
- The meta-analysis pools all GLP-1 receptor agonists [11].
Acute pancreatitis
Acute pancreatitis occurred in 0.22% of trial participants, with no difference between doses.
The numbers and sources
- How common
- Uncommon: between 1 in 1,000 and 1 in 100 people.
- Effect
- Acute pancreatitis occurred in 0.22% of trial participants, with no difference between doses (15 mg against 5 mg RR 0.70, 95% CI 0.27 to 1.82) [23].
- Population
- 15,471 participants in 19 RCTs [23].
- Sources
- [23]
- Caveats
- All trials were industry funded with short to moderate follow-up, and precision was limited [23].
Celiac disease
A global meta-analysis found 1.5% of the general population tested positive for celiac antibodies and 0.8% had celiac disease confirmed by biopsy.
The numbers and sources
- How common
- Uncommon: between 1 in 1,000 and 1 in 100 people.
- Effect
- Global seroprevalence was 1.5% (95% CI 1.3 to 1.8%) and biopsy-confirmed prevalence 0.8% (95% CI 0.6 to 1.0%). Prevalence was 50% higher in females and nearly double in children, and 41.4% of biopsy-confirmed patients had no symptoms [16].
- Population
- 394,274 participants in 87 general population studies [16].
- Sources
- [16]
- Caveats
- Heterogeneity was very high (I² 97.1%), and 36.6% of people testing positive did not have a biopsy [16]. Celiac disease is triggered by gluten in wheat, barley and rye.
Rash and diarrhea on clopidogrel
One trial found severe rash in 0.26% on clopidogrel against 0.10% on aspirin, and severe diarrhea in 0.23% against 0.11%.
The numbers and sources
- How common
- Uncommon: between 1 in 1,000 and 1 in 100 people.
- Effect
- Adverse experiences judged severe included rash (0.26% on clopidogrel against 0.10% on aspirin), diarrhea (0.23% against 0.11%) and upper gastrointestinal discomfort (0.97% against 1.22%). A significant fall in neutrophils occurred in 0.10% on clopidogrel and 0.17% on aspirin [3].
- Population
- 19,185 patients followed a mean 1.91 years [3].
- Sources
- [3]
- Caveats
- The comparator is aspirin 325 mg, not placebo. Only events judged severe are counted.
- Why limited
- This rests on one trial, of 19,185 people. Strength counts independent studies that agree, so one trial is limited at any size.
Fenofibrate: pancreatitis
One trial found slightly more pancreatitis on fenofibrate than placebo, 0.8% against 0.5%, over 5 years. The label reports pancreatitis with fibrates.
The numbers and sources
- How common
- Uncommon: between 1 in 1,000 and 1 in 100 people.
- Effect
- Pancreatitis occurred in 0.8% on fenofibrate and 0.5% on placebo (p=0.031) [8]. The label reports pancreatitis with fenofibrate, gemfibrozil and clofibrate [7].
- Population
- 9,795 adults with type 2 diabetes [8].
- Sources
- [8], [7]
- Caveats
- One trial.
- Why limited
- This rests on one trial, of 9,795 people. Strength counts independent studies that agree, so one trial is limited at any size.
Pancreatitis
Limited evidence: pancreatitis was 0.3% on Saxenda against 0.1% on placebo, while a diabetes trial found it slightly lower on liraglutide.
The numbers and sources
- How common
- Uncommon: between 1 in 1,000 and 1 in 100 people.
- Effect
- Acute pancreatitis was confirmed by adjudication in 0.3% (9 of 3,291) on Saxenda and 0.1% (2 of 1,843) on placebo in adult trials [13]. In LEADER, pancreatitis was nonsignificantly lower on liraglutide than placebo [9].
- Population
- Saxenda trial participants [13]; 9,340 adults with type 2 diabetes [9].
- Sources
- [13], [9]
- Caveats
- Few events. The two sources point in different directions.
Bleeding
Linked to about 40% higher odds of serious bleeding in observational studies, roughly one extra upper gut bleed per 3,177 low-risk people treated.
The numbers and sources
- How common
- Rare: fewer than 1 in 1,000 people.
- Effect
- Across 42 observational studies, SSRI use was associated with severe bleeding at any site (OR 1.41, 95% CI 1.27 to 1.57) [40]. For upper gastrointestinal bleeding, the odds ratio was 1.66 (95% CI 1.44 to 1.92) in case-control studies and 1.68 (95% CI 1.13 to 2.50) in cohort studies. The number needed to harm was 3,177 in a low-risk population and 881 in a high-risk population [41]. The label states that drugs interfering with serotonin reuptake increase the risk of bleeding events, from bruising and nosebleeds to life-threatening hemorrhage [24].
- Population
- 31 case-control studies with 1,255,073 patients and 11 cohort studies with 187,956 [40]; 15 case-control studies with 393,268 participants and 4 cohort studies [41].
- Sources
- [40], [41], [24]
- Caveats
- Observational studies, which cannot rule out confounding by the conditions SSRIs are prescribed for. The band above is the excess in low-risk people, since the sources give no absolute rate.
Severe gut disorder with olmesartan
FDA states olmesartan can cause sprue-like enteropathy, with severe chronic diarrhea and weight loss months to years after starting. A French cohort linked it to malabsorption admissions.
The numbers and sources
- How common
- Rare: fewer than 1 in 1,000 people.
- Effect
- In a series of 22 people on olmesartan with unexplained chronic diarrhea, median weight loss was 18 kg, 14 were hospitalized, celiac disease was ruled out, and all improved after stopping the drug [26]. In a French national cohort, hospitalization for intestinal malabsorption was more frequent on olmesartan than on ACE inhibitors (adjusted rate ratio 2.49, 95% CI 1.73 to 3.57), rising to 10.65 beyond 2 years of use, with no difference in the first year [27]. FDA approved label changes in 2013 and stated that the disorder had not been detected with other ARBs [28]. The olmesartan label carries the warning [29].
- Population
- 22 people seen at one US clinic [26]; 4,546,680 adults starting an ARB or ACE inhibitor, with 218 malabsorption admissions over 9,010,303 person-years [27].
- Sources
- [26], [27], [28], [29]
- Caveats
- A case series and one observational cohort. The evidence is for olmesartan only.
Stomach and intestinal bleeding
Shown to raise stomach and intestinal bleeding with all NSAIDs, about 2 to 4 times, rising with dose and age. Celecoxib had fewer events.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- All NSAID regimens raised upper gastrointestinal complications (perforation, obstruction or bleeding): coxibs RR 1.81, diclofenac 1.89, ibuprofen 3.97 (95% CI 2.22 to 7.10) and naproxen 4.22 (95% CI 2.71 to 6.56) [10]. Gastrointestinal events were less frequent with celecoxib than with naproxen or ibuprofen [11]. The label states these events can occur at any time without warning symptoms, with higher risk in older people [12]. Across 25 studies, odds of gastrointestinal bleeding were 1.16 (95% CI 0.84 to 1.61) for celecoxib, 2.28 (95% CI 1.71 to 3.03) for ibuprofen and 20.67 (95% CI 14.56 to 29.34) for ketorolac [13]. Against non-users, ibuprofen had an odds ratio for upper gastrointestinal bleeding of 2.51 (95% CI 1.33 to 4.74). Against paracetamol, at mostly 1,200 to 1,800 mg a day for a median 1.5 weeks, it did not differ (OR 0.96, 95% CI 0.36 to 2.59) [14]. In trials of celecoxib for up to 10 days for acute pain, gastrointestinal adverse events did not differ from placebo (RR 0.96, 95% CI 0.64 to 1.43) [15].
- Population
- As above [10][11]; 25 studies [13]; 7 RCTs and 10 observational studies with 89,522 participants [14]; 50 RCTs with 10,693 participants [15].
- Sources
- [10], [11], [12], [13], [14], [15]
- Caveats
- Rates rise with dose and age. [13] reported substantial heterogeneity. [14] rated its certainty very low, and [15] rated most outcomes very low certainty.
Lung cancer and other cancers
Linked to about nine times the lung cancer risk of never smoking in pooled studies, and to raised risks of cancers of the larynx, throat, mouth and esophagus.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Current smokers had an RR of 8.96 (95% CI 6.73 to 12.11) for lung cancer, 6.98 for laryngeal, 6.76 for pharyngeal, 3.57 for upper digestive tract and 3.43 for oral cancer, against non-smokers [21]. In a second review, never smokers had an RR of lung cancer death of 0.11 (95% CI 0.07 to 0.15) against current smokers [12]. In UK women, the lung cancer death rate ratio for smokers was 21.4 [3].
- Population
- 216 studies of 13 cancer sites, 1961 to 2003 [21]. 24 studies with 969,560 people [12]. 1.2 million UK women [3].
- Sources
- [21], [12], [3]
- Caveats
- The first review pooled case-control and cohort studies, and study type, sex and confounder adjustment changed the estimates [21].
C. difficile infection
Linked to C. difficile infection outside hospital, about 2.7 times the odds on penicillins or macrolides and 5.7 on cephalosporins, with no link for tetracyclines.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Against no antibiotic, community C. difficile infection was linked to penicillins (OR 2.71, 95% CI 1.75 to 4.21), macrolides (OR 2.65), and cephalosporins with related drugs (OR 5.68), and not to tetracyclines (OR 0.92, 95% CI 0.61 to 1.40) [21]. Each label warns that C. difficile diarrhea has been reported with nearly all antibacterial drugs, ranging from mild diarrhea to fatal colitis [22][19][18][23].
- Population
- 7 observational studies in people outside hospital [21]; label statements [22][19][18][23].
- Sources
- [21], [22], [19], [18], [23]
- Caveats
- Observational studies with no absolute rate in the abstract [21].
Changes to the gut microbiome
Shown to change the gut microbiome, often lowering bacterial diversity and beneficial bacteria, with some changes lasting a year or more after certain antibiotics.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Many studies reported lower bacterial diversity during treatment. Amoxicillin, amoxicillin-clavulanate, cephalosporins and macrolides raised Enterobacteriaceae other than E. coli. Macrolides strongly reduced anaerobic bacteria, while macrolides and doxycycline reduced Enterococcus. Many antibiotics reduced butyrate-producing bacteria. The longest-lasting changes were after ciprofloxacin, clindamycin and clarithromycin with metronidazole, up to four years [24].
- Population
- 2,076 participants and 301 controls in 129 studies [24].
- Sources
- [24]
- Caveats
- A systematic review without pooled numbers. Health effects of these changes were not measured [24].
Esophageal cancer
Mixed results: a meta-analysis linked oral bisphosphonates to higher odds of esophageal cancer, while a large UK cohort found no difference.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 7 studies, exposure to bisphosphonates was linked to esophageal cancer (OR 1.74, 95% CI 1.19 to 2.55), with high heterogeneity, a link for etidronate and none for alendronate [24]. In 41,826 bisphosphonate users and as many controls, esophageal cancer incidence was 0.48 and 0.44 per 1,000 person-years (adjusted HR 1.07, 95% CI 0.77 to 1.49) [25].
- Population
- 19,700 esophageal cancer cases in 7 studies [24]; 83,652 people, 81% women, mean age 70, followed about 4.5 years [25].
- Sources
- [24], [25]
- Caveats
- All observational. Etidronate is not sold for osteoporosis in the US.
Side effects in trials
Reported side effects included flatulence, nausea and headache, with no major health risks across 54 studies.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 54 studies, reported adverse events of oral bromelain included flatulence, nausea and headache, and no major health risks were reported [8]. Adverse events in the knee osteoarthritis trial were generally mild [6].
- Population
- People in clinical studies of bromelain [8]. 47 adults with knee osteoarthritis [6].
- Sources
- [8], [6]
- Caveats
- The abstract gives no adverse event rates [8].
Headache, racing heart, gut upset and anxiety
Shown to raise racing heart, anxiety, insomnia, gut upset and headache in athletes, with several rising with dose.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 48 placebo-controlled trials in 940 athletes (mean dose 4.9 mg per kg), caffeine raised the odds of self-reported tachycardia (log odds ratio 1.47, more than 4 times the odds), anxiety (1.29), insomnia (1.20), abdominal discomfort (1.12), increased urine output (1.04), nervousness (0.82) and headache (0.74). Tachycardia, headache, abdominal discomfort and anxiety rose with dose [17]. A systematic review of 27 studies in healthy people found anxiety symptoms rose with caffeine dose [18].
- Population
- Athletes aged 15 and older, 63% male [17]. Healthy individuals [18].
- Sources
- [17], [18]
- Caveats
- Side effects were self-reported and often secondary outcomes [17]. The anxiety review's search ran to March 2021 and its statistical methods were not fully reported [18].
Digestive side effects
Long-term trials reported constipation, diarrhea and soft stools. Adverse events were about as common with CLA plus exercise as with exercise alone.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Long-term trials reported constipation, diarrhea and soft stools [2]. In trials of CLA with exercise, adverse events did not differ from exercise alone (risk ratio 1.32, 95% CI 0.94 to 1.84) [5].
- Population
- RCTs [2][5].
- Sources
- [2], [5]
- Caveats
- Event counts are not given in the abstract of [2].
Lactose intolerance
A systematic review of trials found most adults with lactose intolerance or malabsorption tolerated 12 to 15 g of lactose, about one cup of milk.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Moderate-quality evidence indicated that 12 to 15 g of lactose is well tolerated by most adults with lactose intolerance or malabsorption. Evidence was insufficient that lactose-reduced milk (0 to 2 g lactose) reduced symptoms against milk with more than 12 g, and insufficient for probiotics or gradual adaptation [18].
- Population
- 36 randomized trials in people with lactose intolerance or malabsorption [18].
- Sources
- [18]
- Caveats
- Most trials studied lactose malabsorption, not symptoms of intolerance [18]. The review gives no prevalence figure.
Rash and adverse events in children
Shown to raise mild adverse events in children, with rash in 7.1% of treated infections against 2.7% on placebo in one trial.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In the 9-trial pediatric meta-analysis, adverse events were more frequent on Echinacea purpurea (RR 1.38, 95% CI 1.08 to 1.78) and were generally mild [5]. In one trial, rash occurred during 7.1% of infections treated with echinacea and 2.7% on placebo (p 0.008), and the overall adverse event rate did not differ [7]. The 5-trial review reported mild gastrointestinal discomfort and skin rashes [6].
- Population
- Children in 9 RCTs [5] and 5 RCTs [6]; 407 children aged 2 to 11 [7].
- Sources
- [5], [6], [7]
- Caveats
- The meta-analysis authors call the pediatric safety profile unclear [5].
Flatulence and bloating
Shown to raise flatulence over control in adults with chronic constipation.
Digestive side effects
Shown to raise diarrhea and upper digestive symptoms in Crohn's disease trials, with no serious adverse events recorded.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In Crohn's disease trials, diarrhea (RR 1.36, 95% CI 1.01 to 1.84, 4 studies, 862 patients) and upper digestive symptoms (RR 1.65, 95% CI 1.25 to 2.18, 5 studies, 999 patients) were more common on omega-3. No serious adverse events were recorded [14]. Of 13 hemodialysis trials, 8 reported no adverse events and 5 described only mild, transient effects such as diarrhea [32].
- Population
- Patients with Crohn's disease in maintenance trials [14]; hemodialysis patients [32].
- Sources
- [14], [32]
- Caveats
- Adverse events were poorly reported in the hemodialysis trials [32].
Liver enzymes and side effects in trials
Liver enzymes did not change in short trials. In one trial, gut side effects were twice as common as on placebo.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In pooled trials, garcinia did not change ALT (Hedges' g 0.27, 95% CI -0.20 to 0.73) or AST (Hedges' g -0.08, 95% CI -0.43 to 0.26) [6]. In one trial included in [1], gastrointestinal adverse events were twice as common with hydroxycitric acid as with placebo [1].
- Population
- 444 participants in 9 publications [6]; RCTs [1].
- Sources
- [1], [6]
- Caveats
- Trials were short and too small to detect rare liver injury. The registry and case findings [7][8][9][10] and the trial enzyme data describe different things.
Digestive side effects
Weight loss trials reported abdominal discomfort, diarrhea and constipation. In a pediatric trial, adverse events were about as common as on placebo.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Adverse events in weight loss trials included abdominal discomfort, diarrhea and constipation [4]. In the pediatric trial, adverse events did not differ from placebo [7].
- Population
- RCTs [4][7].
- Sources
- [4], [7]
- Caveats
- Event rates are not given in the abstract of [4].
Digestive side effects
Shown to cause more gastrointestinal adverse events than lower-protein diets across trials.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Adverse gastrointestinal events were more common with high-protein diets in a meta-analysis of 74 trials [6].
- Population
- Adults in 74 trials of higher against lower protein [6].
- Sources
- [6]
- Caveats
- The abstract does not give rates or say which events [6].
Stomach side effects
Gut upset was slightly more common than on placebo in mood disorder trials, and less common than on metformin in PCOS.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Gastrointestinal upset was marginally more common on inositol than placebo (P = 0.06) [12]. Against metformin, myo-inositol likely caused fewer gastrointestinal adverse events [3].
- Population
- 11 trials in mood and anxiety disorders [12]; 30 trials in PCOS [3].
- Sources
- [3], [12]
- Caveats
- The guideline review describes the events as typically mild and self-limited [3].
Gut side effects
Shown to raise gut side effects with ferrous sulfate, about 2.3 times the odds on placebo, in adults.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 20 placebo-controlled trials, ferrous sulfate raised the odds of gastrointestinal side effects (OR 2.32, 95% CI 1.74 to 3.08, I² 53.6%). Against intravenous iron the OR was 3.05 (95% CI 2.07 to 4.48). In pregnant women the OR was 3.33 (95% CI 1.19 to 9.28). The odds did not track dose [11].
- Population
- 43 RCTs, 6,831 adults [11].
- Sources
- [11]
- Caveats
- Ferrous sulfate only. Other iron salts were not analyzed.
Gallbladder and bile duct disease
Across GLP-1 drug trials, shown to raise gallbladder and bile duct disease about 37%, and more in weight loss trials, at higher doses and with longer use.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across GLP-1 receptor agonist trials, the relative risk of gallbladder or biliary disease was 1.37 (95% CI 1.23 to 1.52), and 2.29 (95% CI 1.64 to 3.18) in weight loss trials. Risk was higher at higher doses and with longer use [12]. Gallstones were observed more often with liraglutide alone than with liraglutide plus exercise [6].
- Population
- 76 RCTs with 103,371 patients [12]; 195 adults [6].
- Sources
- [12], [6]
- Caveats
- [12] pools all GLP-1 receptor agonists, not only liraglutide.
Gastrointestinal side effects
Linked to gut side effects more often in women than men on metformin, at about 1.85 times the odds.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 7 studies, women had higher odds of gastrointestinal adverse events attributed to metformin than men (OR 1.85, 95% CI 1.58 to 2.17) [25].
- Population
- 7,968 participants, 3,106 women and 4,862 men, in 5 cohort studies, 1 case-control study and 1 RCT [25].
- Sources
- [25]
- Caveats
- Mostly observational. The abstract does not give the overall rate of gastrointestinal effects [25].
Adverse events in trials
Mixed results: most reviews found adverse events about as common as on placebo, while one found more, mostly gut effects.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across the Cochrane trials, adverse events did not differ significantly from placebo or no intervention (RR 0.83, 95% CI 0.46 to 1.50) [1]. Adverse events were comparable with placebo at 420 and 700 mg three times a day [2], and did not differ between groups in the NASH trial [6]. In the 2025 Cochrane review of fatty liver trials, serious adverse events (Peto OR 1.55, 95% CI 0.26 to 9.28) and non-serious ones (RR 1.29, 95% CI 0.88 to 1.89) did not differ significantly from placebo or no treatment, at low and very low certainty [7]. A 2025 meta-analysis of fatty liver trials found more people with adverse effects on silymarin (RR 1.98, 95% CI 1.11 to 3.54), mostly gastrointestinal [8].
- Population
- Adults with liver disease in RCTs [1][6][2][7][8].
- Sources
- [1], [6], [2], [7], [8]
- Caveats
- Trials lasted up to about a year, so longer use was not studied.
Stopping treatment for side effects
Shown to raise stopping for side effects about 1.6 times over placebo, a 3% absolute difference, mostly from gut effects.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The risk of discontinuing for adverse events was 1.59 (95% CI 1.21 to 2.08) times that of placebo, a 3% absolute difference. Gastrointestinal events caused 40% of withdrawals [10]. A network meta-analysis found odds of 1.71 (95% CI 1.42 to 2.05) against lifestyle change alone [11].
- Population
- 16 orlistat trials of 12 to 24 months [10]; 132 RCTs with 48,209 adults [11].
- Sources
- [10], [11]
- Caveats
- [10] included placebo-controlled trials at licensed doses and excluded weight maintenance trials.
Fundic gland polyps and stomach cancer
Linked to more fundic gland polyps with use of a year or longer, and to about 1.4 times the risk of stomach cancer in a few observational studies.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Pooled odds ratios for fundic gland polyps were 1.43 (95% CI 1.24 to 1.64) in a fixed-effects model and 2.45 (95% CI 1.24 to 4.83) in a random-effects model. The pooled risk ratio for stomach cancer was 1.43 (95% CI 1.23 to 1.66) [36]. The label states most people with these polyps had no symptoms and the polyps were found by chance on endoscopy [3].
- Population
- 12 studies with more than 87,324 patients, 4 of them on stomach cancer [36].
- Sources
- [36], [3]
- Caveats
- The authors state the cancer association could be biased by the few studies and possible confounding [36].
Colorectal cancer from processed meat
IARC classifies processed meat as causing colorectal cancer, with risk up 18% per daily 50 g portion. A 2019 review rated the link very small and low certainty.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- IARC's working group, reviewing more than 800 studies, found sufficient evidence in humans that processed meat causes colorectal cancer, and estimated an 18% rise in risk for each 50 g eaten daily [1]. Across 56 cohorts, each 3 fewer servings of processed meat a week was linked to very small decreases in overall cancer death, prostate cancer death, and esophageal, colorectal and breast cancer, at low to very low certainty [10].
- Population
- More than 800 studies, mainly large prospective cohorts [1]. More than 6 million participants in 56 cohorts [10].
- Sources
- [1], [10]
- Caveats
- IARC states that the risk for an individual remains small and rises with the amount eaten [1]. The 2019 review cites residual confounding and recall bias [10].
Gallbladder and bile duct disease
Shown to raise gallbladder and bile duct disease about 37% across GLP-1 drug trials, more at higher doses and longer use. The analysis pooled all GLP-1 drugs.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across GLP-1 receptor agonist trials, the relative risk of gallbladder or biliary disease was 1.37 (95% CI 1.23 to 1.52), including gallstones (RR 1.27) and cholecystitis (RR 1.36). In weight loss trials it was 2.29 (95% CI 1.64 to 3.18). Risk was higher at higher doses and longer use [8].
- Population
- 76 RCTs with 103,371 patients, mean age 57.8 [8].
- Sources
- [8]
- Caveats
- The meta-analysis pools all GLP-1 receptor agonists, not only semaglutide.
Cancer
Mixed results: IARC classes night shift work as probably carcinogenic, mainly from case-control and animal studies, while ten prospective cohorts found no rise in breast cancer.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- IARC found limited evidence in humans, with positive associations between night shift work and cancers of the breast, prostate, colon and rectum in the largest case-control studies but inconsistent results in cohort studies. It found sufficient evidence in animals for altered light-dark schedules, and classed night shift work as probably carcinogenic to humans (Group 2A) [12]. In 10 prospective studies, any night shift work had a breast cancer RR of 0.99 (95% CI 0.95 to 1.03), and 20 or more years an RR of 1.01 (95% CI 0.93 to 1.10) [13].
- Population
- Studies of cancer in exposed people and lifetime studies in mice, reviewed in 2019 [12]. 1.4 million women in 10 prospective studies, 4,660 breast cancers in night shift workers [13].
- Sources
- [12], [13]
- Caveats
- IARC gave case-control studies more weight because they measured shift work in more detail [12]. Group 2A describes the strength of evidence that a hazard exists, not the size of any risk.
Bleeding with NSAIDs, aspirin and blood thinners
Linked to more bleeding when combined: about 4 times the odds of an upper gut bleed with an NSAID, and about a third more major bleeds with anticoagulants.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Taking an SSRI together with an NSAID was associated with upper gastrointestinal bleeding at an odds ratio of 4.25 (95% CI 2.82 to 6.42) [41]. With oral anticoagulants, the pooled hazard ratio for major bleeding was 1.35 (95% CI 1.14 to 1.58) against anticoagulants alone [42]. In people with atrial fibrillation, the rate ratio was 1.33 (95% CI 1.24 to 1.42), highest in the first 30 days (1.74), and present with both direct anticoagulants (1.25) and warfarin-type drugs (1.36) [43]. The label states that aspirin, NSAIDs, other antiplatelet drugs, warfarin and other anticoagulants may add to the bleeding risk [24].
- Population
- Case-control and cohort studies [41]; 98,070 patients in 8 studies [42]; 42,190 people with major bleeding and 1,156,641 matched controls, mean age 74 [43].
- Sources
- [41], [42], [43], [24]
- Caveats
- Observational. The sources give relative figures and no absolute rate for the combination.
NSAIDs
Linked to about twice the odds of stomach and gut bleeding when an NSAID was taken with warfarin, compared with warfarin alone.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 11 studies, gastrointestinal bleeding was more frequent with warfarin plus an NSAID than with warfarin alone (OR 1.98, 95% CI 1.55 to 2.53), and with warfarin plus a COX-2 inhibitor (OR 1.90, 95% CI 1.46 to 2.46). Any bleeding was more frequent with warfarin plus an NSAID (OR 1.58, 95% CI 1.18 to 2.12) [22]. The label lists NSAIDs, including celecoxib, ibuprofen and naproxen, among drugs that can increase the risk of bleeding [11].
- Population
- 11 studies comparing warfarin with an NSAID against warfarin alone [22].
- Sources
- [22], [11]
- Caveats
- Mostly observational studies. The abstract gives odds ratios, not the share of people who bled.
Nausea, taste disturbance and other minor effects
Shown to raise minor side effects such as unpleasant taste and nausea about 34% when used to treat colds.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- When zinc was used to treat colds, non-serious adverse events rose (RR 1.34, 95% CI 1.15 to 1.55, 16 studies, 2,084 participants, moderate certainty). Adverse events tracked in the trials included unpleasant taste, vomiting, stomach cramps and diarrhea. Prevention trials showed RR 1.11 (95% CI 0.84 to 1.47) for adverse events and 1.67 (95% CI 0.78 to 3.57) for serious adverse events [1].
- Population
- 31 trials reporting non-serious adverse events, 2,422 participants [1].
- Sources
- [1]
- Caveats
- No treatment trial reported serious adverse events [1].
Deaths, heart, stomach and kidney events in long-term users
Linked to more deaths, cardiovascular events, gastrointestinal bleeds and kidney function loss at higher doses in cohort studies of regular users.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A systematic review found 8 cohort studies. One of two reporting mortality found the relative rate rose with dose from 0.95 (95% CI 0.92 to 0.98) to 1.63 (1.58 to 1.68). All four reporting cardiovascular events found a dose response, one with risk ratios from 1.19 (0.81 to 1.75) to 1.68 (1.10 to 2.57). One reported gastrointestinal events or bleeds rising from 1.11 (1.04 to 1.18) to 1.49 (1.34 to 1.66). Three of four reporting kidney outcomes found a dose response, one with odds of a 30% or greater fall in estimated glomerular filtration rate from 1.40 (0.79 to 2.48) to 2.19 (1.4 to 3.43) [25].
- Population
- Adults in 8 cohort studies comparing paracetamol use with no use [25].
- Sources
- [25]
- Caveats
- Observational. The authors state that channelling bias, where paracetamol is chosen for people already at higher risk, may have had an important impact on the results [25].
Interaction with acetaminophen and NSAID pain relievers
FDA requires over-the-counter acetaminophen labels to warn of severe liver damage, and NSAID labels of stomach bleeding, with 3 or more drinks every day.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Federal labeling rules require acetaminophen products to warn that severe liver damage may occur with 3 or more alcoholic drinks every day while using the product, and NSAID products to warn that the chance of severe stomach bleeding is higher with 3 or more drinks a day [23]. A review states that alcohol enhances the breakdown of acetaminophen into a toxic product [22].
- Population
- US labeling regulation [23]. Narrative review [22].
- Sources
- [23], [22]
- Caveats
- The regulation states the warning and gives no rate.
Adverse effects in trials
Limited evidence: in dialysis patients, 5 of 17 stopped calcium AKG within 2 weeks for stomach and bowel upset. Trials of related AKG salts reported them well tolerated.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In 19 hemodialysis patients switched from calcium carbonate, 5 of 17 (29%) were withdrawn from calcium ketoglutarate within 1 to 2 weeks for anorexia, vomiting, diarrhea or general uneasiness. All 5 had stomach or bowel symptoms beforehand, and the other 12 reported no side effects [9]. In 28 hemodialysis patients, high blood calcium occurred in 1 on calcium ketoglutarate and 8 on calcium acetate [10]. In 35 trained men, arginine AKG at 12 g a day for 8 weeks was reported as well tolerated, with clinical blood markers measured against placebo [11].
- Population
- Adults on hemodialysis [9][10]. 35 resistance-trained men aged 30 to 50 [11].
- Sources
- [9], [10], [11]
- Caveats
- The dialysis trials were open label with no placebo, in people with kidney failure, and used AKG as a phosphate binder [9][10]. Arginine AKG is a different salt [11]. No adverse event counts were located for the calcium AKG products sold for aging.
Nausea, vomiting and dizziness
One trial found nausea, vomiting and vertigo rose with dose from 600 to 1,800 mg a day over 5 weeks.
Other interactions on the label
The label names thyroid medication, guanethidine, anticholinergic drugs and epinephrine with local anesthetics as combinations that need close supervision. It gives no rates.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Amitriptyline may block the blood pressure effect of guanethidine. Close supervision is required in people taking thyroid medication. Combining it with anticholinergic or sympathomimetic drugs, including epinephrine with local anesthetics, requires dose adjustment. Hyperpyrexia has been reported with anticholinergic or neuroleptic drugs in hot weather, and paralytic ileus with anticholinergic drugs [13].
- Population
- Labeling statements [13].
- Sources
- [13]
- Caveats
- No rates are given.
Doxycycline: sunburn, swallowing irritation and pressure in the head
The doxycycline label warns of exaggerated sunburn, irritation and ulcers of the esophagus, and raised pressure inside the skull, which can threaten vision.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The label reports photosensitivity as an exaggerated sunburn reaction, advises enough fluid to reduce esophageal irritation and ulceration, and reports intracranial hypertension with headache, blurred or double vision and possible permanent vision loss, noting overweight women of childbearing age as at higher risk [23].
- Population
- Label statements [23].
- Sources
- [23]
- Caveats
- No rates given.
Interactions with alcohol, sedatives, ritonavir and fruit juice
The labels warn that alcohol and other sedatives add to antihistamine drowsiness, ritonavir raised cetirizine levels by 42%, and fexofenadine's label says not to take it with fruit juice.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The levocetirizine label states alcohol and other central nervous system depressants may further reduce alertness, and that ritonavir raised cetirizine exposure by about 42% [1]. The fexofenadine label says not to take it with fruit juices or at the same time as aluminum or magnesium antacids [12]. The diphenhydramine sleep-aid label asks people taking sedatives or tranquilizers to consult a doctor and to avoid alcohol [13].
- Population
- Labeling statements and pharmacokinetic studies [1][12][13].
- Sources
- [1], [12], [13]
- Caveats
- No rate of harm is given.
Omeprazole and esomeprazole with clopidogrel
The label warns that omeprazole and esomeprazole significantly reduce clopidogrel's antiplatelet activity. One trial found no difference in cardiovascular events with omeprazole.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The label states that omeprazole significantly reduced the antiplatelet activity of clopidogrel when given together or 12 hours apart, that esomeprazole had a similar effect, and that dexlansoprazole, lansoprazole and pantoprazole had less effect [22]. In a trial of people on aspirin and clopidogrel, cardiovascular events occurred in 4.9% on omeprazole and 5.7% on placebo (HR 0.99, 95% CI 0.68 to 1.44), and gastrointestinal events in 1.1% against 2.9% (HR 0.34, 95% CI 0.18 to 0.63) [28].
- Population
- Pharmacodynamic studies summarized in labeling [22]; 3,761 patients with coronary artery disease followed to 180 days [28].
- Sources
- [22], [28]
- Caveats
- The trial stopped short of its planned enrollment, and its authors state that it does not rule out a meaningful difference in cardiovascular events [28].
- Why limited
- This rests on one trial, of 3,761 people. Strength counts independent studies that agree, so one trial is limited at any size.
NSAIDs, including ibuprofen blocking aspirin's effect
The labels warn that NSAIDs raise the risk of bleeding with either drug. A small study found ibuprofen taken before aspirin blocked aspirin's effect on platelets.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The clopidogrel label states that NSAIDs taken with clopidogrel increase the risk of gastrointestinal bleeding [22]. The aspirin label states that other NSAIDs increase the risk of bleeding and may impair kidney function, and that ibuprofen can interfere with the antiplatelet effect of low-dose aspirin [23]. In a crossover study, aspirin's inhibition of platelet thromboxane and aggregation was blocked when a single daily dose of ibuprofen was given before aspirin and when ibuprofen was given several times a day. Rofecoxib, acetaminophen and diclofenac did not have this effect [31].
- Population
- Statements in labeling [22][23]; volunteers in a crossover pharmacodynamic study [31].
- Sources
- [22], [23], [31]
- Caveats
- The ibuprofen study measured platelet function, not heart attacks or strokes. The labels give no rates.
Opioids and clopidogrel absorption
The label states that opioids delay and reduce the absorption of clopidogrel, lowering exposure to its active metabolites. It gives no outcome rate.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The clopidogrel label states that opioid agonists such as morphine delay and reduce the absorption of clopidogrel, presumably through slowed stomach emptying, resulting in reduced exposure to its metabolites [22].
- Population
- Interaction data summarized in labeling [22].
- Sources
- [22]
- Caveats
- A change in drug exposure, with no rate of clots given.
Liver reactions and Reye's syndrome on the aspirin label
The aspirin label lists indigestion, raised liver enzymes, hepatitis and Reye's syndrome among adverse reactions. It gives no rates.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The prescription aspirin label lists dyspepsia, hepatic enzyme elevation, hepatitis and Reye's syndrome among gastrointestinal adverse reactions. It also states that salicylate can reduce kidney clearance of methotrexate, leading to bone marrow toxicity, and can change blood levels of phenytoin and valproic acid [23].
- Population
- Reports summarized in labeling [23].
- Sources
- [23]
- Caveats
- The label gives no frequencies and covers aspirin at all doses.
Slower stomach emptying in diabetic gastroparesis
One small study found 30 ml of ACV with a meal slowed stomach emptying in 10 adults with type 1 diabetes and gastroparesis.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In 10 patients with type 1 diabetes and gastroparesis, 30 ml of ACV with a meal lowered the median gastric emptying rate from 27% to 17% (p < 0.05). The authors note this could be a disadvantage for glucose control [8].
- Population
- 10 adults with type 1 diabetes and gastroparesis [8].
- Sources
- [8]
- Caveats
- One small pilot crossover study.
Tablet contents and throat injury
Case reports: one person had throat injury from an ACV tablet. Tests of 8 tablet brands found wide variation and doubt that ACV was in them.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- After an adverse event report of esophageal injury from an ACV tablet, 8 tablet products were tested. Tablet size, pH, acid content and label claims varied widely between brands, and it was doubtful whether ACV was an ingredient in the products tested [9].
- Population
- Product testing following one case [9].
- Sources
- [9]
- Caveats
- One 2005 sample of 8 products.
Gastrointestinal side effects and headache
Small trials found more frequent stools, cramps, nausea and headaches on bacopa than placebo, with no serious reactions.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In 98 older Australians, bacopa caused more frequent stools, abdominal cramps and nausea than placebo [7]. In 54 older adults, adverse events were 9 on bacopa and 10 on placebo, mainly stomach upset [6]. In 101 adults aged 40 to 70, self-reported adverse reactions were more frequent on bacopa than placebo (p = 0.024), mainly digestive complaints and headaches, with no serious reactions [5].
- Population
- Trial participants over 55 [6][7]. Adults aged 40 to 70 [5].
- Sources
- [7], [6], [5]
- Caveats
- Three small 12-week trials.
Interactions with calcium, antacids, aspirin and some other drugs
The labels warn that calcium and antacids block alendronate absorption, aspirin added gut side effects, and aminoglycosides or loop diuretics may lower calcium further with zoledronic acid.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Calcium supplements, antacids and oral medicines with multivalent cations interfere with alendronate absorption. Upper gastrointestinal events were more frequent with alendronate above 10 mg a day plus aspirin. In a 3-year trial where most people took NSAIDs, upper gastrointestinal events were similar on alendronate and placebo [15]. The zoledronic acid label advises caution with aminoglycosides, which may lower calcium for prolonged periods, and with loop diuretics, which may raise the risk of low calcium [13].
- Population
- Label statements and trial data [15][13].
- Sources
- [15], [13]
- Caveats
- Mostly label warnings, not measured rates.
Pancreatitis from very high triglycerides
Case reports: a 61-year-old man on a carnivore diet developed acute pancreatitis caused by severe hypertriglyceridemia.
The numbers and sources
Bowel perforation
Case reports: tears of the rectum after colonic irrigation by alternative practitioners, leading to pelvic abscesses, surgery and colostomy.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Three women aged 51 to 59 developed rectal perforation after colonic irrigation by alternative practitioners, each presenting with sepsis 1 to 7 days later. All needed surgery, and two needed a stoma or colostomy [12]. In Singapore, rectal perforation after colonic hydrotherapy caused life-threatening perineal gangrene [13].
- Population
- Three women [12]. One patient [13].
- Sources
- [12], [13]
- Caveats
- Case reports give no rate.
Infection spread by irrigation equipment
An outbreak investigation linked at least 36 cases of amebiasis to colonic irrigation at one clinic, where the machine stayed contaminated after routine cleaning.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- From 1978 to 1980, at least 36 people who had colonic irrigation at a chiropractic clinic in Colorado developed amebiasis, and 10 needed colectomy. Bloody diarrhea occurred in 21% of the irrigation group and 1% of other clinic patients, and evidence of amebic infection in 37% and 2.4%. The risk was highest for people irrigated right after someone with bloody diarrhea, and the machine was heavily contaminated with fecal bacteria after routine cleaning [14].
- Population
- 176 clinic patients in the last 4 months of 1980, and outbreak cases from 1978 to 1980 [14].
- Sources
- [14]
- Caveats
- One outbreak at one clinic, more than 40 years ago.
Coffee enema colitis, burns and deaths
Case reports: colitis and rectal burns after coffee enemas, and deaths in two people who used them very often, with low sodium and chloride at autopsy.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A systematic review found 9 case reports of harm. Seven described colitis, rectal burns or perforation after self-administered coffee enemas, two of them blamed on hot coffee. Two people who gave themselves frequent coffee enemas died, and autopsy showed a low-salt pattern of low sodium and chloride that the authors attributed to the salt-free coffee. A patient with breast cancer that had spread to the liver died with septicemia from bowel bacteria after frequent coffee enemas [10]. A separate report describes proctocolitis in a healthy patient [11].
- Population
- 9 case reports from the US, Korea and Japan [10]. One patient [11].
- Sources
- [10], [11]
- Caveats
- Case reports give no rate. The deaths and the septicemia occurred in seriously ill people [10].
Lower absorption of some antibiotics
Small crossover studies found milk and yogurt cut ciprofloxacin absorption by 30% to 36%, and milk cut tetracycline absorption by 65%.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Taken with 300 ml of milk or yogurt instead of water, 500 mg of ciprofloxacin had a 36% and 47% lower peak blood level and 30% to 36% lower total absorption [21]. Milk reduced absorption of tetracycline by 65% and minocycline by 27% against water [22].
- Population
- 7 healthy volunteers in a randomized crossover trial [21]. Two groups of 8 volunteers [22].
- Sources
- [21], [22]
- Caveats
- Small single-dose studies measuring blood levels, not treatment outcomes.
Pancreatitis
The label reports pancreatitis at 3.4 per 1,000 patient-years on dulaglutide against 2.7 on other drugs, and pancreatic enzyme rises of 14% to 20%.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In the registration trials, pancreatitis-related reactions occurred at 3.4 per 1,000 patient-years on dulaglutide and 2.7 on non-incretin comparators, and adjudicated pancreatitis at 1.4 and 0.88. Lipase and pancreatic amylase rose 14% to 20% from baseline, against up to 3% on placebo. Fatal and non-fatal hemorrhagic or necrotizing pancreatitis has been observed with GLP-1 receptor agonists [1].
- Population
- Adults in the registration trials [1].
- Sources
- [1]
- Caveats
- Few events, given per patient-year rather than per person.
Inhaling stomach contents under anesthesia
The label reports rare cases of pulmonary aspiration during anesthesia or deep sedation in people on GLP-1 drugs, with food still in the stomach despite fasting.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Dulaglutide delays gastric emptying. Rare postmarketing reports describe pulmonary aspiration during elective procedures under general anesthesia or deep sedation in people on GLP-1 receptor agonists who had retained stomach contents despite following fasting instructions [1].
- Population
- Postmarketing reports [1].
- Sources
- [1]
- Caveats
- The label states the data are insufficient to say whether changing fasting or pausing the drug would reduce the risk [1].
Medicines taken by mouth
The label states dulaglutide slows stomach emptying and may slow absorption of oral medicines, though 1.5 mg did not change tested drugs to a clinically relevant degree.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The delay in gastric emptying is largest after the first dose and lessens over time. In pharmacology studies, 1.5 mg did not affect absorption of the tested oral medicines to a clinically relevant degree. The label advises monitoring levels of oral drugs with a narrow therapeutic index, such as warfarin, and notes limited experience at 3 and 4.5 mg [1].
- Population
- Clinical pharmacology studies described in the label [1].
- Sources
- [1]
- Caveats
- No rate of harm is given.
Allergic reactions
Case reports: rare allergic reactions, which may be severe. Gastrointestinal upset and rash were the most frequent adverse events reported.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A systematic review of trials, spontaneous reporting programs, WHO data and manufacturer files found gastrointestinal upset and rash to be the most frequent adverse events. In rare cases, echinacea was associated with allergic reactions that may be severe [9].
- Population
- Clinical studies and spontaneous reports [9].
- Sources
- [9]
- Caveats
- Spontaneous reports cannot give a rate. The review found little data on use in pregnancy and lactation [9].
Salmonella food poisoning
FDA expected its egg safety rule to prevent about 79,000 illnesses and 30 deaths a year from eggs contaminated with Salmonella Enteritidis.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- FDA states that egg-associated Salmonella illness can cause mild to severe gut illness, short-term or chronic arthritis, or death. Its rule requires preventive measures in poultry houses and refrigeration in storage and transport [11].
- Population
- US population, as estimated by FDA [11].
- Sources
- [11]
- Caveats
- A regulator's estimate of illnesses prevented, not a measured rate per egg eaten.
Poisoning from juice pressed with leaves and stems
Case reports: 11 of 25 people had nausea and vomiting after drinking juice from wild elderberries crushed with leaves and stems. All recovered.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In August 1983, 11 of 25 people at a California gathering had nausea and vomiting within 15 minutes of drinking juice from wild elderberries crushed with their leaves and branches. Eight were flown to hospital and one was hospitalized overnight. Severity tracked the amount drunk. All recovered. Serum cyanide levels were normal. The CDC report notes that fresh leaves, flowers, bark, buds and roots contain a glucoside that can produce hydrocyanic acid, and that uncooked berries may produce nausea [7].
- Population
- 25 people at one gathering [7].
- Sources
- [7]
- Caveats
- One outbreak report, involving a western US species (Sambucus mexicana), not a commercial extract.
Fenofibrate: gallstones
The label warns fenofibrate, like other fibrates, may raise cholesterol in bile and lead to gallstones.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Fenofibrate, like clofibrate and gemfibrozil, may increase cholesterol excretion into bile, leading to gallstones. A clofibrate trial found more gallstones and gallbladder inflammation than placebo [7]. The ezetimibe label adds that both drugs may raise this risk together [2].
- Population
- Label statements [7][2].
- Sources
- [7], [2]
- Caveats
- The label cites older fibrate trials, not a fenofibrate rate.
Gut side effects
Small trials found mild gut side effects in some studies, with no liver or kidney toxicity or severe adverse events.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In diabetes trials, no liver or kidney toxicity or severe adverse events were observed, and mild gastrointestinal side effects appeared in some studies [2]. The older-men trial observed no side effects [6].
- Population
- 706 participants in 10 RCTs [2]; 95 men [6].
- Sources
- [2], [6]
- Caveats
- Trials were short and not designed to detect rare harms.
Stomach cancer with pickled vegetables
Linked to about 50% higher stomach cancer risk in a meta-analysis of 60 studies of pickled vegetables, mostly from Korea, China and Japan.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Pickled vegetable or food intake was linked to stomach cancer (OR 1.52, 95% CI 1.37 to 1.68), 1.32 in cohort studies and 1.56 in case-control studies. The link was 1.89 in Korean, 1.86 in Chinese and 1.16 in Japanese studies, and not significant elsewhere (OR 1.14, 95% CI 0.96 to 1.35) [13].
- Population
- 50 case-control and 10 prospective studies [13].
- Sources
- [13]
- Caveats
- Observational, with high heterogeneity. The pickled foods studied were not all fermented.
Esophageal obstruction
Case reports: a woman with an esophageal web had her esophagus blocked after taking a glucomannan diet aid.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A 37-year-old woman developed delayed esophageal obstruction after an over-the-counter glucomannan diet aid and cleared it by vomiting before endoscopy. She was later found to have an esophageal web. The report lists gastrointestinal obstruction and changed absorption of other medicines among reported effects of glucomannan [10].
- Population
- One case report [10].
- Sources
- [10]
- Caveats
- A single case in a person with existing esophageal disease.
Antacids and gabapentin
The label reports that an antacid containing aluminum and magnesium hydroxides lowered the amount of gabapentin absorbed by about 20%.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Mean bioavailability of gabapentin fell by about 20% when it was taken with an aluminum and magnesium hydroxide antacid. The label also states that gabapentin does not interfere with the metabolism of other common seizure medicines [19]. The pregabalin label states that pregabalin is unlikely to be involved in significant pharmacokinetic interactions [7].
- Population
- Interaction studies summarized in labeling [19].
- Sources
- [19], [7]
- Caveats
- A change in absorption, with no rate of harm. The evidence is for gabapentin.
Esophageal and gut obstruction
Case reports: esophageal blockage after a glucomannan diet aid, and stomach outlet blockage linked to konjac flour noodles.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A 37-year-old woman developed delayed esophageal obstruction after an over-the-counter glucomannan diet aid and cleared it by forceful vomiting just before endoscopy. She was later found to have an esophageal web. The authors describe glucomannan as expanding rapidly to many times its original size and list gastrointestinal obstruction among its reported effects [9]. A 1986 report addressed glucomannan and the risk of esophageal obstruction [10], and a 2018 report described gastric outlet obstruction associated with konjac flour noodles [11].
- Population
- Case reports [9][10][11].
- Sources
- [9], [10], [11]
- Caveats
- Case reports cannot give a rate. The 2007 patient had prior upper gastrointestinal pathology [9]. Abstracts were not available for [10] and [11].
Adverse events in venous trials
Limited evidence: across phlebotonic trials, adverse events were slightly more common than on placebo, mostly digestive. Only one trial tested grape seed extract.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 37 trials of phlebotonics (5,789 participants), adverse events were slightly more common than on placebo (RR 1.14, 95% CI 1.02 to 1.27), mostly digestive [7].
- Population
- Adults with chronic venous insufficiency in RCTs [7].
- Sources
- [7]
- Caveats
- This pools all phlebotonics, and only one included trial tested grape seed extract. No review of grape seed extract safety was sourced.
Higher blood levels of budesonide
The FDA states grapefruit juice can interact with budesonide. One small study in 8 men found juice for 4 days about doubled its bioavailability.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The FDA names budesonide (Entocort EC, Uceris) among drugs grapefruit juice can interact with [1]. Regular-strength juice, 200 mL three times a day for 4 days, about doubled the bioavailability of both plain and extended-release budesonide capsules [15].
- Population
- 8 healthy men [15].
- Sources
- [1], [15]
- Caveats
- One small open study, with a corresponding author at AstraZeneca, the maker of a budesonide product [15].
Esophageal cancer with very hot tea
Linked to five times the esophageal cancer risk when burning-hot tea was combined with 15 g or more of alcohol a day, in one large Chinese cohort.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Against people drinking tea less than weekly and under 15 g of alcohol a day, those drinking burning-hot tea with 15 g or more of alcohol daily had higher esophageal cancer risk (HR 5.00, 95% CI 3.64 to 6.88). Current smokers who drank burning-hot tea daily had HR 2.03 (95% CI 1.55 to 2.67) [11]. In the Cochrane review, cohort studies found higher esophageal cancer risk with more green tea, while case-control studies did not [9].
- Population
- 456,155 Chinese adults aged 30 to 79 followed a median 9.2 years [11].
- Sources
- [11], [9]
- Caveats
- Observational, with tea temperature self-reported once. The cohort abstract does not say which type of tea people drank [11].
Pancreatitis with suspected liver injury
Case reports: a woman taking only water and green tea catechin supplements for 2 weeks developed severe pancreatitis and suspected toxic hepatitis.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A 36-year-old woman who took only water and green tea catechin supplements for 2 weeks developed severe acute pancreatitis with highly raised liver and pancreatic enzymes and suspected toxic hepatitis. She recovered and left hospital after 15 days [11].
- Population
- One case report [11].
- Sources
- [11]
- Caveats
- One case. She had eaten no food for the 2 weeks, and the abstract does not name the product or dose [11].
The acid effect fading with daily use (tolerance)
Small studies in healthy men found the acid-lowering effect of famotidine and ranitidine fell within 5 to 14 days of continuous daily dosing.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In a crossover study, the acid-lowering effect of famotidine and ranitidine declined over 14 days of continuous use, most clearly at night, while blood drug levels stayed the same [15]. On ranitidine 150 mg four times daily, mean 24-hour stomach pH was 4.22 on day 1 and 3.28 on day 5, and time above pH 4 fell from 54.3% to 30.1% [16].
- Population
- 7 healthy Japanese men without H. pylori [15]; 28 healthy men [16].
- Sources
- [15], [16]
- Caveats
- Small studies in healthy volunteers measuring stomach pH, not symptoms. One studied ranitidine alone [16].
Interactions with famotidine
The famotidine label warns it can lower absorption of drugs that need stomach acid and may sharply raise tizanidine levels. It gives no rate.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The label states famotidine can reduce absorption of drugs that depend on stomach acid, such as dasatinib, delavirdine, cefditoren, fosamprenavir, atazanavir, ketoconazole and itraconazole. It describes famotidine as a weak CYP1A2 inhibitor that may substantially raise tizanidine levels, with low blood pressure, slow heart rate or drowsiness to watch for [2].
- Population
- Labeling statement [2].
- Sources
- [2]
- Caveats
- The tizanidine interaction was not studied clinically [2].
Digestive intolerance in pregnancy
One small trial found more digestive intolerance on iodine in pregnant women.
The numbers and sources
Pancreatitis
Case reports: a review found 25 published cases of pancreatitis on isotretinoin, 4 likely due to high triglycerides. No rate could be given.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Among 125 papers, 11 described 25 cases of isotretinoin-associated pancreatitis, 4 likely due to high triglycerides. The authors called triglyceride-related pancreatitis exceedingly rare and found idiosyncratic pancreatitis the more frequent type [14]. The label reports rare fatal hemorrhagic pancreatitis, with normal or raised triglycerides [3].
- Population
- Published case reports [14]; postmarketing reports [3].
- Sources
- [14], [3]
- Caveats
- The review states its data cannot give a frequency [14].
Serious adverse events in preterm infants
One trial found 16 serious adverse events on lactoferrin against 10 on sucrose in very preterm infants, 2 judged possibly related.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In the 2,203-infant trial, 16 serious adverse events occurred on lactoferrin and 10 on sucrose. Two on lactoferrin, one case of blood in stool and one death after intestinal perforation, were judged possibly related [3].
- Population
- Very preterm infants in UK hospitals [3].
- Sources
- [3]
- Caveats
- Serious events in very preterm infants have many causes. The numbers are small.
Gastrointestinal upset and rash
Limited evidence: in one trial four people dropped out for abdominal discomfort, nausea and rash. Trials were too small to estimate rates.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In the 49-week mycelium trial, four participants dropped out because of abdominal discomfort, nausea and skin rash, and no other adverse events were reported [3]. In the 16-week trial, laboratory tests showed no adverse effects [1]. A systematic review lists stomach discomfort, headache and allergic reactions as possible side effects that commonly go unreported [4].
- Population
- Older adults in trials [1][3]. Review of trials and a case report [4].
- Sources
- [1], [3], [4]
- Caveats
- Trials were too small to estimate rates.
Interaction with ciprofloxacin
Small trials found an aluminum and magnesium antacid taken up to 4 hours before ciprofloxacin cut its absorption. Taken 6 hours before or 2 hours after, it did not.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In healthy men, an aluminum and magnesium antacid taken 5 to 10 minutes, 2 hours or 4 hours before ciprofloxacin left 15.1%, 23.2% and 70% of its relative bioavailability. Taken 6 hours before or 2 hours after, it did not change absorption [16].
- Population
- Healthy male volunteers in crossover studies [16].
- Sources
- [16]
- Caveats
- The antacid combined aluminum and magnesium salts, so the share due to magnesium alone is not separated.
Bowel twisting after abdominal massage in premature infants
Case reports: 17 cases of volvulus in premature infants after abdominal massage, 4 of them fatal, in a review of 60 pediatric massage studies.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Of 60 studies of massage in children, 16 reported at least one adverse event. There were 20 mild, 26 moderate and 18 severe events. Of the severe events, 17 were volvulus in premature infants given abdominal massage, and 4 were fatal [21].
- Population
- Children aged 0 to 18 in 60 studies [21].
- Sources
- [21]
- Caveats
- The reviewers say it is not yet defined whether the link is causal, and 31 of the 60 studies gave no adverse event information [21].
Gallbladder disease and incontinence
Limited evidence: one trial reported more gallbladder disease and urinary incontinence during estrogen plus progestin, with most risks fading after stopping.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- During estrogen plus progestin treatment, the WHI reported more gallbladder disease and more urinary incontinence. Most risks faded after stopping [5].
- Population
- WHI trial participants aged 50 to 79 [5].
- Sources
- [5]
- Caveats
- The abstract lists these without event counts.
Gut and urinary effects, discoloration and monitor interference
Limited evidence: gut and urinary effects were the most common reasons for stopping a related compound. The label warns it interferes with pulse oximetry readings.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Gastrointestinal and urinary effects were the most common adverse events at both higher LMTM doses and the most common reasons for stopping [1]. In the bipolar trial, side effects were described as transient and mild [5]. The label warns that methylene blue interferes with pulse oximetry readings [6].
- Population
- Trial participants in [1] and [5]; label [6].
- Sources
- [1], [5], [6]
- Caveats
- The trials were not designed to rank side effects.
Reactions to the drug form
Limited evidence: at antidote doses for acetaminophen poisoning, acetylcysteine has caused reactions from nausea to death, and intravenous dosing anaphylaxis-like reactions.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- As an antidote for acetaminophen poisoning, acetylcysteine has caused reactions from nausea to death, most deaths from incorrect dosing. Intravenous dosing causes anaphylaxis-like reactions with rash, itching, swelling and bronchospasm. Women and people with asthma or atopy were more susceptible [13].
- Population
- Patients treated for acetaminophen poisoning [13].
- Sources
- [13]
- Caveats
- Antidote doses are far higher than supplement doses. The review reports reaction frequency with oral dosing as at least as high as with intravenous dosing [13].
Serious side effects, infection and bleeding
One trial found more serious gut, muscle, skin, infection and bleeding events with niacin plus laropiprant. EMA suspended these products in 2013.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Against placebo, niacin with laropiprant raised serious adverse events of the gut (1.0 percentage point), muscles and joints (0.7), skin (0.3), infection (1.4) and bleeding (0.7), all P of .003 or less [2]. EMA suspended these products across the EU in 2013, stating their benefits no longer outweighed their risks [10].
- Population
- 25,673 adults with vascular disease, median 3.9 years [2].
- Sources
- [2], [10]
- Caveats
- One trial of a combination with laropiprant [2].
- Why limited
- This rests on one trial, of 25,673 people. Strength counts independent studies that agree, so one trial is limited at any size.
Glucose tolerance and gut bacteria
One trial found saccharin and sucralose for 2 weeks impaired glucose tolerance against controls, with changes in gut bacteria that varied from person to person.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Saccharin, sucralose, aspartame and stevia each changed stool and oral bacteria and blood metabolites. Saccharin and sucralose significantly impaired glycemic responses against controls given glucose or nothing. Mice given gut bacteria from the people with the largest and smallest responses reproduced their donors' glucose responses [16].
- Population
- 120 healthy adults in a randomized trial of 2 weeks [16].
- Sources
- [16]
- Caveats
- One trial of 2 weeks, with doses below the acceptable daily intake. The authors say clinical implications still need assessing [16].
Masking of bowel blockage
The label warns ondansetron can mask a worsening ileus or stomach distension after abdominal surgery or chemotherapy. It gives no rate.
The numbers and sources
Label warnings: thyroid tumors, pancreatitis and gallbladder
The label warns of thyroid C-cell tumors seen with related drugs in rodents, with human relevance not determined. Pancreatitis and gallstones were slightly more common.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The label carries a boxed warning about thyroid C-cell tumors. Such tumors occurred in rodents with GLP-1 drugs that are active in rats and mice, while orforglipron is not active in rats or mice and did not produce tumors in them. The label states that the human relevance has not been determined, and the drug is contraindicated with a personal or family history of medullary thyroid carcinoma or MEN 2. In the weight trials, acute pancreatitis was confirmed in 6 people on orforglipron (0.14 per 100 years of exposure) against 1 on placebo (0.04), gallstones in 1% against 0.7%, acute kidney injury in 0.2% against 0.05%, low blood pressure in 2% against 0.5%, and hair loss in 4 to 5% against 2% [6].
- Population
- Label pool of the two weight trials and nonclinical studies [6].
- Sources
- [6]
- Caveats
- The thyroid warning rests on animal findings for the drug class. Pancreatitis events were few.
Drug interactions
The label caps the dose at 9 mg with strong CYP3A4 inhibitors, says to avoid some others, and notes it may affect absorption of other oral medicines.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The label states that strong CYP3A4 inhibitors raise orforglipron exposure and sets a maximum of 9 mg once daily with them. It states that strong CYP3A4 inhibitors that also inhibit OATP1B, such as ritonavir, and strong CYP3A4 inducers are to be avoided, and that simvastatin is not to exceed 20 mg a day. Orforglipron delays gastric emptying and may affect the absorption of other oral medicines [6].
- Population
- Label [6].
- Sources
- [6]
- Caveats
- Label guidance drawn from pharmacology studies, not outcome trials.
Reduced absorption of other drugs and fat-soluble vitamins
The label warns orlistat can reduce the effect of drugs such as cyclosporine, levothyroxine and warfarin, and reduce absorption of some fat-soluble vitamins.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The Xenical label reports serious outcomes from loss of effect of cyclosporine, levothyroxine, warfarin, amiodarone, antiepileptic drugs and antiretroviral drugs taken with orlistat, and reduced absorption of some fat-soluble vitamins and beta carotene [9]. The Alli label lists organ transplant and cyclosporine use as reasons not to use it [8].
- Population
- Postmarketing reports and interaction data in the label [8][9].
- Sources
- [9], [8]
- Caveats
- Label statements, not trial rates.
Slower gut recovery after antibiotics
One study in mice and people found a multi-strain probiotic delayed the gut microbiome's return after antibiotics, compared with spontaneous recovery.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- After antibiotics, a multi-strain probiotic delayed and left incomplete the return of the native stool and mucosal microbiome compared with spontaneous recovery, in mice and humans. Autologous fecal transplant restored it within days [51].
- Population
- Mice and human volunteers. The abstract does not give the number of people [51].
- Sources
- [51]
- Caveats
- Microbiome measures, not clinical outcomes.
Cancer from unprocessed red meat
IARC classifies red meat as probably causing cancer, on limited evidence in people, mainly for colorectal cancer, with links also to pancreatic and prostate cancer.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- IARC classified red meat as Group 2A on limited evidence in humans and strong mechanistic evidence. The link was seen mainly for colorectal cancer, with associations also for pancreatic and prostate cancer [1]. Each 3 fewer servings a week of unprocessed red meat was linked to a very small reduction in lifetime cancer death, at low certainty [10].
- Population
- More than 800 studies [1]. 56 cohorts [10].
- Sources
- [1], [10]
- Caveats
- IARC describes the human evidence as limited [1].
Adverse effects at high doses
One trial at up to 1,000 mg twice daily found nausea, diarrhea and weight loss, and more brain volume loss than placebo in Alzheimer disease.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- At up to 1,000 mg twice daily for 52 weeks, the most common adverse events were nausea, diarrhea and weight loss. Brain volume loss was greater on resveratrol than placebo [13]. Most trials in a blood pressure meta-analysis reported no serious adverse events [3].
- Population
- 119 people with mild to moderate Alzheimer disease [13]; 17 RCTs [3].
- Sources
- [13], [3]
- Caveats
- The trial authors wrote that further studies are needed to interpret the biomarker changes [13]. One trial in a disease population.
Stomach cancer at higher salt intakes
Linked to stomach cancer in cohorts, with 68% higher risk at high against low intake. A salt substitute trial found a nonsignificant trend toward fewer stomach cancers.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Pooled across 7 prospective studies, high salt intake was linked to more stomach cancer than low intake (RR 1.68, 95% CI 1.17 to 2.41), and moderately high intake too (RR 1.41, 95% CI 1.03 to 1.93), with a stronger link in Japanese populations [17]. In the large salt substitute trial, stomach cancer did not differ significantly (RR 0.77, 95% CI 0.54 to 1.08) [18].
- Population
- 268,718 adults with 1,474 cases, followed 6 to 15 years [17]. 20,996 older Chinese adults, mean 4.7 years, 212 stomach cancers [18].
- Sources
- [17], [18]
- Caveats
- Observational studies, often measuring salty foods rather than sodium, open to confounding. The trial analysis was post hoc [18].
Reported side effects and serious case reports
Case reports: death and brain bleeding appeared in isolated reports with questionable causality. Stomach upset, headache and lower libido were the most often reported effects.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A systematic review of 40 articles, plus WHO and national reporting schemes, found the most frequent adverse events were abdominal pain, diarrhea, nausea, fatigue, headache, decreased libido and rhinitis. Death and cerebral hemorrhage appeared in isolated case reports and spontaneous reports, with causality questionable. No drug interactions were reported [9]. In the Permixon review, gastrointestinal disorders were the most frequent reaction, at 3.8% [4].
- Population
- 26 RCTs, other trials and case reports [9].
- Sources
- [9], [4]
- Caveats
- Spontaneous reports cannot give a rate. The authors note adverse event reporting was poor [9].
Poisoning from a mislabeled supplement
Case reports: 201 people who took a supplement with 200 times its labeled selenium had diarrhea, fatigue, hair loss and nail changes.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- A liquid supplement contained 200 times its labeled selenium. Of 201 cases in 10 states, diarrhea (78%), fatigue (75%), hair loss (72%), joint pain (70%) and nail changes (61%) were common. At 90 days or more, 52% still had nail discoloration or loss and 29% hair loss [14].
- Population
- 201 people in an outbreak investigation, 1 hospitalized [14].
- Sources
- [14]
- Caveats
- A case series from one product.
Bleeding with NSAIDs, aspirin and blood thinners
The labels warn that NSAIDs, aspirin, warfarin and other anticoagulants may add to bleeding risk, and report increased bleeding with warfarin. They give no rate.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The duloxetine label states that epidemiological studies linking serotonin reuptake drugs to upper gastrointestinal bleeding also showed that an NSAID or aspirin taken at the same time may potentiate the risk, and that altered anticoagulant effects, including increased bleeding, have been reported when SSRIs or SNRIs are taken with warfarin [18]. The venlafaxine label names aspirin, NSAIDs, warfarin and other anticoagulants as adding to the risk [10].
- Population
- Labeling statements drawn from epidemiological studies and reports [18][10].
- Sources
- [18], [10]
- Caveats
- No rate is given, and the studies cited by the labels mostly concern SSRIs.
Birth control pills and other medicines taken by mouth (label)
The label warns that tirzepatide lowers birth control pill levels and tells users to switch to or add a non-oral method for 4 weeks after starting and each dose increase.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- The label states that tirzepatide delays stomach emptying, which lowers exposure to oral hormonal contraceptives. The delay is largest after the first dose and lessens over time. It tells people using birth control pills to switch to a non-oral method, or add a barrier method, for 4 weeks after starting and for 4 weeks after each dose increase. Contraceptives not taken by mouth are not expected to be affected. It names warfarin among medicines with a narrow therapeutic range to monitor [25].
- Population
- Clinical pharmacology studies, as reported in the label [25].
- Sources
- [25]
- Caveats
- The label does not report pregnancy rates on combined use.
Liver, skin and stomach reactions on the label
The label lists hepatitis and raised liver enzymes, allergic reactions, rash, hair loss, nausea and diarrhea among other adverse reactions. It gives no rates.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Other adverse reactions on the label include hypersensitivity reactions including hives and anaphylaxis, vasculitis, hepatitis and elevated liver enzymes, nausea, vomiting, diarrhea, abdominal pain, rash, itching, hair loss and calcification of the windpipe [11].
- Population
- Reports summarized in labeling [11].
- Sources
- [11]
- Caveats
- The label gives no frequencies or comparator rates for these reactions.
Mixed results15
Colorectal cancer
Mixed results: 20-year follow-up of older trials found fewer colon cancers on aspirin, while recent trials found no drop or more cancer deaths.
The numbers and sources
- Effect
- In 20-year follow-up of four trials, allocation to aspirin lowered colon cancer incidence (HR 0.76, 95% CI 0.60 to 0.96) and mortality (HR 0.65, 95% CI 0.48 to 0.88), and not rectal cancer (HR 0.90, 95% CI 0.63 to 1.30) [20]. In adults with diabetes followed a mean 7.4 years, gastrointestinal tract cancer occurred in 2.0% of each group [14]. In healthy adults aged 70 or over, cancer-related death occurred in 3.1% on aspirin against 2.3% on placebo (HR 1.31, 95% CI 1.10 to 1.56) [21]. The US Preventive Services Task Force stated in 2022 that the evidence is unclear on whether aspirin reduces colorectal cancer incidence or mortality [15].
- Population
- 14,033 patients in four trials, median follow-up 18.3 years [20]; 15,480 adults with diabetes [14]; 19,114 adults aged 70 or over [21].
- Sources
- [20], [14], [21], [15]
- Caveats
- Not an approved use. The authors of the trial in older adults called their cancer finding unexpected [21].
Stomach pain and irritable bowel syndrome in children
Mixed results: pooled trials found more children treated successfully than with no intervention, while a primary care trial found no difference in relief at 12 months.
Compared with no intervention [9]; care as usual [10]
The numbers and sources
- Effect
- Hypnotherapy led to treatment success more often than no intervention (RR 2.86, 95% CI 1.19 to 6.83, number needed to treat 5), at low certainty [9]. In 152 children aged 7 to 17 treated in primary care, home-based guided hypnotherapy added to usual care did not change adequate relief at 12 months (79.5% against 74.3%, adjusted OR 1.47). More children had relief at 3 months (adjusted OR 2.74) and 6 months (4.26) [10].
- Population
- 91 children in 2 trials of hypnotherapy against no intervention [9]. 152 children in Dutch primary care [10].
- Sources
- [9], [10]
- Caveats
- The pooled result rests on two small trials at risk of bias [9]. Relief was high in both groups by 12 months [10].
Diarrhea in young children
Mixed results: a meta-analysis found fewer children with diarrhea, while a 555-child trial found no change in how often it occurred, only shorter episodes.
The numbers and sources
- Effect
- A 2025 meta-analysis of 14 trials found fewer children with diarrhea on oral lactoferrin than on placebo (OR 0.56, 95% CI 0.41 to 0.75) [2]. In 555 children aged 12 to 18 months followed for 6 months, diarrhea incidence did not differ (5.4 against 5.2 episodes a year). Episodes were shorter (4.8 against 5.3 days), and moderate or severe dehydration was less common (1.0% against 2.6%) [7].
- Population
- Children under 18 [2]. Weaned children in Peru [7].
- Sources
- [2], [7]
- Caveats
- One meta-analysis. Its abstract does not report heterogeneity or certainty of evidence [2]. The 555-child trial was funded by NIH's NICHD, and its first author is the senior author of the review [7][2].
Headache, irritable bowel syndrome and other conditions
Mixed results: an overview of 27 reviews found possible relief in migraine and irritable bowel syndrome, and no relief in acute low back pain, fibromyalgia or other headaches.
Compared with no treatment, sham treatment or other non-osteopathic treatment [16]
The numbers and sources
- Effect
- Osteopathic treatment may relieve symptoms in adults with migraine and irritable bowel syndrome. It did not appear to relieve acute nonspecific low back pain, fibromyalgia, headaches of various causes, lower urinary tract symptoms in women, or cerebral palsy in children. Evidence for vertigo, COPD, high blood pressure and gynecological complaints was insufficient [16]. An earlier overview rated the evidence for children's conditions, headache and irritable bowel syndrome limited and inconclusive [17].
- Population
- 27 systematic reviews covering nine indications [16]. 9 reviews with 55 trials and 3,740 participants [17].
- Sources
- [16], [17]
- Caveats
- Included reviews were rated low or critically low in quality [17], and the trials were heterogeneous and partly of poor quality [16].
Acute infectious diarrhea
Mixed results: low-bias trials found no change in diarrhea risk or duration, while Chinese trials found S. boulardii shortened gastroenteritis in children.
The numbers and sources
- Effect
- In trials at low risk of bias, probiotics did not change the risk of diarrhea lasting 48 hours or more (RR 1.00, 95% CI 0.91 to 1.09, 2 trials, 1,770 participants) or diarrhea duration (MD 8.64 hours shorter, 95% CI 29.4 hours shorter to 12.1 hours longer, very low certainty) [18]. A 2025 review of 10 Chinese trials (1,125 children) found Saccharomyces boulardii CNCM I-745 shortened acute gastroenteritis (SMD -1.63, 95% CI -2.08 to -1.18) and raised the cure rate (RR 1.47) [19].
- Population
- 82 studies, 12,127 participants, mostly children [18]. Children in China receiving rehydration therapy [19].
- Sources
- [18], [19]
- Caveats
- Publication bias appeared on funnel plots, and heterogeneity was marked across all studies [18]. The reviews disagree. The S. boulardii review found no eligible trials outside Chinese databases [19].
Stomach protection with aspirin, clopidogrel or blood thinners
Mixed results: omeprazole cut stomach bleeding events in people on aspirin and clopidogrel, while pantoprazole did not cut overall upper gut events in people on aspirin or rivaroxaban.
The numbers and sources
- Effect
- In people on aspirin and clopidogrel, upper gut events over 180 days were 1.1% on omeprazole and 2.9% on placebo (HR 0.34, 95% CI 0.18 to 0.63), and overt upper gut bleeding fell (HR 0.13) [8]. In people with stable heart or artery disease on low-dose rivaroxaban, aspirin or both, upper gut events did not differ (102 of 8,791 on pantoprazole against 116 of 8,807 on placebo, HR 0.88, 95% CI 0.67 to 1.15). Bleeding from stomach and duodenal lesions fell (HR 0.52, 95% CI 0.28 to 0.94), with 982 needing treatment to prevent one [9].
- Population
- 3,761 patients with coronary disease on dual antiplatelet therapy [8]; 17,598 patients with stable cardiovascular or peripheral artery disease, median 3 years [9].
- Sources
- [8], [9]
- Caveats
- The first trial ended early with fewer people than planned [8]. The two trials enrolled different populations at different bleeding risk.
Throat reflux (laryngopharyngeal reflux)
Mixed results: two meta-analyses found throat reflux symptom scores improved more than on placebo, but disagreed on response rates, and throat exam findings did not differ.
Compared with placebo [14][15]
The numbers and sources
- Effect
- One meta-analysis found a higher response rate on a proton pump inhibitor (risk difference 0.15, 95% CI 0.01 to 0.30) and better reflux symptom index scores (SMD 1.65), with no difference in the reflux finding score seen on laryngoscopy (SMD 0.62, 95% CI -0.96 to 2.19) [14]. A second found better symptom index scores (SMD 3.65, 95% CI 1.56 to 5.75) but no significant difference in response rate or the reflux finding score [15].
- Population
- 14 randomized trials with 771 participants [14]; 13 randomized trials with 831 participants [15].
- Sources
- [14], [15]
- Caveats
- Small trials with differing definitions of response. The two analyses overlap in the trials they include.
Inflammatory bowel disease
Mixed results: one review found about 36% fewer relapses in inflammatory bowel disease, mostly Crohn's in remission, while another found no change in relapse or activity.
The numbers and sources
- Effect
- Across 7 RCTs (458 patients), vitamin D lowered clinical relapse against placebo (RR 0.64, 95% CI 0.46 to 0.89). In Crohn's disease in remission the RR was 0.47 (95% CI 0.27 to 0.82), and ulcerative colitis had only 2 studies (67 patients) [37]. In adults, the Harvey Bradshaw Index for Crohn's disease fell by 1.47 points (95% CI -2.47 to -0.47) and hs-CRP fell by 1.58 mg/L [38]. A meta-analysis of 17 trials (1,127 patients) found lower CRP (SMD -0.33) and no change in disease activity (SMD -0.13, 95% CI -0.66 to 0.39) or relapse (RR 0.59, 95% CI 0.19 to 1.86) [39].
- Population
- Adults with Crohn's disease or ulcerative colitis [37][38][39].
- Sources
- [37], [38], [39]
- Caveats
- The reviews disagree on relapse. Evidence for ulcerative colitis is thin [37].
Fecal incontinence
Limited evidence: single small trials found biofeedback added to exercises or electrical stimulation improved continence, and the Cochrane review could not draw firm conclusions.
Compared with sphincter exercises alone [14]; electrical stimulation alone [14]; sham training [14]; sacral nerve stimulation [14]
The numbers and sources
- Effect
- Biofeedback plus exercises beat exercises alone (RR for not reaching full continence 0.70, 95% CI 0.52 to 0.94, one trial), and adding biofeedback to electrical stimulation beat stimulation alone (RR 0.47, one trial). Rectal volume discrimination training improved continence more than sham training in some data. Sacral nerve stimulation gave fewer incontinence episodes than conservative care including biofeedback [14].
- Population
- 1,525 adults in 21 trials [14].
- Sources
- [14]
- Caveats
- Few trials for each comparison and methodological weaknesses [14].
Collagenous colitis
One very small trial in collagenous colitis found more remission than placebo per protocol, 63.6% against 26.7%, but not by intention to treat.
The numbers and sources
- Effect
- In 31 patients with chronic diarrhea from collagenous colitis, 400 mg three times a day for 6 weeks led to remission in 63.6% against 26.7% on placebo per protocol (p 0.04). By intention to treat, it was 43.8% against 26.7% (p 0.25). Histology and quality of life did not differ [5].
- Population
- 31 randomized, 26 analyzed per protocol [5].
- Sources
- [5]
- Caveats
- Very small. The intention-to-treat result was not significant [5].
Bowel preparation before colonoscopy
Mixed results: one trial found a drinkable laxative solution cleaned the bowel better than colon hydrotherapy, while observational studies reported adequate cleansing with hydrotherapy devices.
Compared with polyethylene glycol electrolyte solution taken by mouth [2][3]; no comparison group [4]
The numbers and sources
- Effect
- In a randomized trial of 196 outpatients, the polyethylene glycol solution gave better colon cleanliness, fewer adverse effects and higher examiner satisfaction. Patients were more satisfied with hydrotherapy, and preference and ileocecal arrival did not differ [2]. In 109 people whose first preparation failed, same-day hydrotherapy gave slightly higher Boston Bowel Preparation Scale scores than a second oral preparation, 7 against 6.5 (P = 0.038) [3]. In 28 people prepared by hydrotherapy alone, 25 (89.3%) reached adequate cleansing [4].
- Population
- 196 outpatients in China [2]. 109 people with failed preparation, retrospective [3]. 28 consecutive patients, no control group [4].
- Sources
- [2], [3], [4]
- Caveats
- One randomized trial. The other two studies were retrospective or uncontrolled.
Diet in adult gardeners
One randomized trial found a community garden plot raised fiber intake by about 1.4 g a day, with no change in fruit and vegetable intake or overall diet quality.
Compared with a waiting list for a community garden plot [7]
The numbers and sources
- Effect
- Fiber intake showed a significant time-by-intervention effect (p = 0.034), with a mean between-group difference of 1.41 g a day at harvest time (99.5% CI -2.09 to 4.92). Combined fruit and vegetable intake and the Healthy Eating Index did not change [7].
- Population
- 291 adults, three diet recalls at each of three time points [7].
- Sources
- [7]
- Caveats
- One trial in one US region. The difference was small and its strict interval crosses zero [7].
3 more
Vomiting with chemotherapy
Limited evidence: one review found 60% lower odds of acute vomiting with chemotherapy at 1 g a day or less, and a larger review found no change.
The numbers and sources
- Effect
- Across 18 articles, ginger at 1 g a day or less for more than 3 days cut the odds of acute vomiting by 60% (OR 0.4, 95% CI 0.17 to 0.81, 3 studies, 301 participants, moderate certainty). Overall and delayed vomiting and nausea severity showed no significant association with ginger [4]. A 2026 meta-analysis of 13 RCTs (1,265 participants) found no significant change in acute vomiting (RR 0.73, 95% CI 0.51 to 1.06) or delayed vomiting (RR 1.17, 95% CI 0.75 to 1.83). In subgroups, the effect was larger in patients under 50 [5].
- Population
- Adults receiving chemotherapy [4][5].
- Sources
- [4], [5]
- Caveats
- The acute vomiting result in [4] rests on 3 studies, and the larger review [5] did not reproduce it. Review [4] was funded by Cancer Council Queensland.
Crohn's disease
Small trials found more clinical and endoscopic responses than placebo in Crohn's disease, while remission did not differ significantly. Evidence was rated low quality.
The numbers and sources
- Effect
- A Cochrane review found 2 RCTs (46 participants). In 34 adults, 4.5 mg a day for 12 weeks led to clinical remission in 30% against 18% on placebo (RR 1.48, 95% CI 0.42 to 5.24). A 70-point clinical response occurred in 83% against 38% (RR 2.22, 95% CI 1.14 to 4.32), and endoscopic response in 72% against 25% (RR 2.89, 95% CI 1.18 to 7.08). Endoscopic remission did not differ significantly [9].
- Population
- 34 adults with active Crohn's disease and 12 children [9].
- Sources
- [9]
- Caveats
- The review rated the evidence as low quality because of sparse data and found it insufficient for firm conclusions [9].
Constipation
Limited evidence: magnesium oxide improved stool frequency and consistency in about half of small studies in functional constipation.
The numbers and sources
- Effect
- A 2026 systematic review of 7 studies (690 people, 5 of them RCTs) found better stool frequency than the comparator in 4 studies and better stool consistency in 4. Both studies that used a validated constipation quality-of-life tool found between-group improvement. No serious adverse events were reported [9].
- Population
- Infants, children and adults with functional constipation. Magnesium oxide was the most common form in adults [9].
- Sources
- [9]
- Caveats
- Narrative synthesis because of heterogeneity, certainty not formally graded, small samples and confounded interventions. Findings apply to magnesium oxide [9].
Not shown to help12
Crohn's disease and ulcerative colitis
Not shown to prevent relapse of Crohn's disease in the two large low-bias trials, or of ulcerative colitis.
The numbers and sources
- Effect
- A Cochrane review of 6 studies (1,039 patients) found 39% relapsed on omega-3 at 12 months against 47% on placebo (RR 0.77, 95% CI 0.61 to 0.98). In the two large low risk-of-bias trials (738 patients) it was 37% against 42% (RR 0.88, 95% CI 0.74 to 1.05) [14]. In those two trials, 4 g a day for up to 58 weeks did not change relapse at 1 year (31.6% against 35.7%, HR 0.82, and 47.8% against 48.8%, HR 0.90) [15]. In ulcerative colitis, 3 studies (138 patients) found relapse rates similar to placebo (RR 1.02, 95% CI 0.51 to 2.03) [16]. Across 13 RCTs in people with bowel disease, relapse had RR 0.85 (95% CI 0.72 to 1.01), from low-quality evidence [17].
- Population
- Patients with Crohn's disease in remission [14][15]. People with ulcerative colitis in remission [16]. Adults in trials of 24 weeks or more [17].
- Sources
- [14], [15], [16], [17]
- Caveats
- The Cochrane authors rated the pooled Crohn's result very low quality because of heterogeneity and publication bias [14]. The ulcerative colitis review had few patients [16].
Constipation in children
Not shown to increase bowel movements in children with functional constipation compared with placebo or standard treatment.
The numbers and sources
- Effect
- In a network meta-analysis of 41 RCTs, probiotics did not increase weekly bowel movements compared with placebo or any conventional treatment [5]. A second network meta-analysis of 15 RCTs (1,087 children) found no difference from placebo in weekly bowel movements for any probiotic, prebiotic or synbiotic [6]. An umbrella review found no effect on stool frequency (WMD 0.22, 95% CI -0.30 to 0.74) [7].
- Population
- Children with functional constipation [5][6]. Children in pooled meta-analyses [7].
- Sources
- [5], [6], [7]
- Caveats
- Confidence in the network estimates ranged from very low to moderate [5][6]. Adults were not studied in these reviews.
Indigestion and gastroparesis symptoms
Not shown to improve functional dyspepsia or gastroparesis symptoms more than placebo. Bloating alone improved in two small trials.
The numbers and sources
- Effect
- Across three trials, buspirone did not improve functional dyspepsia or gastroparesis symptoms against placebo (SMD -0.14, 95% CI -0.44 to 0.17). Bloating severity improved (SMD -0.41, 95% CI -0.77 to -0.04, 2 studies) [12]. In a 4-week trial in people with gastroparesis symptoms, early fullness scores did not differ from placebo (difference -0.11, 95% CI -0.68 to 0.45) [13].
- Population
- 283 people in 10 studies, 5 of them RCTs [12]; 96 patients, 92% women [13].
- Sources
- [12], [13]
- Caveats
- Small trials, most lasting 4 weeks. Not an approved use.
Gut permeability
Not shown to change gut permeability in adults with various diseases. A subgroup taking more than 30 g a day showed a reduction.
The numbers and sources
- Effect
- Across 10 RCTs (352 participants, mean age 46.5, mixed health conditions), glutamine did not change intestinal permeability (WMD -0.00, 95% CI -0.04 to 0.03). A subgroup above 30 g a day showed a reduction [3]. In 10 men running 60 minutes at 30°C, 0.25 to 0.9 g per kg of fat-free mass 2 hours before lowered a permeability marker; GI symptoms did not change [4].
- Population
- Adults with various diseases [3]; recreationally active men in heat [4].
- Sources
- [3], [4]
- Caveats
- The meta-analysis abstract gives the subgroup dose as both 30 g and 30 mg a day, and its confidence interval (-0.10 to -0.08) does not contain its estimate (-0.01) [3]. A lab marker change without a symptom change [4].
Irritable bowel syndrome, compared with other psychological therapies
Not shown to differ from cognitive behavioral therapy or other psychological therapies for irritable bowel syndrome in a network meta-analysis of 41 trials.
Compared with cognitive behavioral therapy in several formats, and other psychological therapies [3]
The numbers and sources
- Effect
- Self-guided or minimal-contact CBT (RR 0.61), face-to-face CBT (RR 0.62) and gut-directed hypnotherapy (RR 0.67) all reduced the chance of remaining symptomatic, and none was superior to another. CBT-based therapies and gut-directed hypnotherapy had the largest evidence base and the largest long-term effects [3].
- Population
- 4,072 adults in 41 trials [3].
- Sources
- [3]
- Caveats
- Few trials compared therapies head to head, so most comparisons are indirect [3].
Bowel inflammation and death in preterm infants
Not shown to change necrotizing enterocolitis or deaths in preterm infants.
The numbers and sources
- Effect
- Lactoferrin did not change necrotizing enterocolitis stage II or III (RR 1.10, 95% CI 0.86 to 1.41, 7 studies, 4,874 infants) or all-cause mortality (RR 0.90, 95% CI 0.69 to 1.17, 11 studies, moderate certainty). With probiotics, sepsis fell (RR 0.25) and necrotizing enterocolitis fell in one study (RR 0.04, very low certainty) [1].
- Population
- Preterm infants [1].
- Sources
- [1]
- Caveats
- The combination studies were few and of poor methodological quality [1].
Appetite and weight gain
Not shown to improve appetite scores more than placebo in two trials of people with cancer, though energy intake rose in one.
The numbers and sources
- Effect
- In people with incurable solid tumors and cancer-related loss of appetite and weight, appetite scores rose on mirtazapine 15 mg and on placebo, with no difference between them after 28 days [5]. In people with advanced lung cancer and anorexia, appetite scores did not differ from placebo at 4 or 8 weeks. Energy intake was 379.3 kcal higher on mirtazapine at 4 weeks, and fewer people had sarcopenia at 8 weeks (57.1% against 82.8%) [6]. In depression trials, increased appetite was reported as a side effect by 17% against 2% on placebo [7].
- Population
- 100 assessable patients with incurable solid tumors [5]; 86 patients with advanced non-small cell lung cancer [6]; 453 adults with depression on mirtazapine and 361 on placebo [7].
- Sources
- [5], [6], [7]
- Caveats
- Not an approved use. Both trials were in cancer. No placebo-controlled trial of mirtazapine for low appetite or low weight in other groups was located. See the weight gain block under risks.
Crohn's disease
Not shown to bring or keep remission in Crohn's disease, in very small studies.
The numbers and sources
- Effect
- A Cochrane review of 2 studies (46 participants) found no difference from placebo in inducing remission after 6 months (RR 1.06, 95% CI 0.65 to 1.71, very low certainty) [22]. A Cochrane review of 7 small maintenance studies found no significant reduction in relapse with E. coli Nissle (RR 0.43, 95% CI 0.15 to 1.20) or Lactobacillus GG after surgery (RR 1.58, 95% CI 0.30 to 8.40) or medical treatment (RR 0.83, 95% CI 0.25 to 2.80) [23].
- Population
- Adults and children with Crohn's disease [22][23].
- Sources
- [22], [23]
- Caveats
- Studies were very small and could not be pooled for maintenance [23].
Crohn's disease remission
One trial found boswellia did not keep more people with Crohn's disease in remission than placebo over 52 weeks, 59.9% against 55.3%.
The numbers and sources
- Effect
- In 82 patients with Crohn's disease in remission, a boswellia extract at 6 × 400 mg a day for up to 52 weeks kept 59.9% in remission against 55.3% on placebo (p 0.85). Time to relapse was 171 days against 185. Disease activity and inflammation markers did not differ [4].
- Population
- 82 randomized outpatients at 22 German centers, 66 analyzed [4].
- Sources
- [4]
- Caveats
- The trial was stopped early because the drug and placebo did not separate [4].
Bowel recovery after surgery
One trial found intravenous ipamorelin did not significantly shorten time to the first solid meal after bowel surgery, 25.3 against 32.6 hours.
The numbers and sources
- Effect
- In a randomized, double-blind, placebo-controlled phase 2 trial of intravenous ipamorelin after bowel resection, median time to the first tolerated solid meal was 25.3 hours on ipamorelin and 32.6 hours on placebo (p = 0.15). No key or secondary efficacy measure differed between the groups [4].
- Population
- 117 adults having open or laparoscopic small or large bowel resection, 114 of them analyzed, treated twice daily for up to 7 days or until discharge [4].
- Sources
- [4]
- Caveats
- A small proof-of-concept trial that enrolled patients with a broad range of underlying conditions, as its authors note [4]. It tested hospital use after surgery, not the uses people take ipamorelin for.
Stomach ulcers
Small trials found deglycyrrhizinated licorice healed stomach and duodenal ulcers no better than placebo. Added to antibiotics, licorice raised H. pylori clearance in one trial.
Compared with placebo [9][10][11]; cimetidine [12]; clarithromycin-based triple therapy alone [13]
The numbers and sources
- Effect
- In 96 people with gastric ulcer, healing after 4 weeks did not differ between deglycyrrhizinated licorice and placebo, by gastroscopy, radiology, ulcer area or symptoms [9]. A crossover trial of 760 mg three times a day for 4 weeks in 38 people found no faster healing than placebo [10]. In 47 people with duodenal ulcer, a month of deglycyrrhizinated licorice showed no advantage over placebo [11]. Against cimetidine in 100 people with gastric ulcer, healing did not differ, about 63% at 6 weeks and 91% at 12 weeks [12]. Added to clarithromycin-based triple therapy for 2 weeks, licorice cleared H. pylori in 83.3% against 62.5% on triple therapy alone [13].
- Population
- 96 [9], 38 [10] and 100 [12] adults with gastric ulcer. 47 adults with duodenal ulcer [11]. 120 adults with H. pylori and dyspepsia, 30% with peptic ulcer [13].
- Sources
- [9], [10], [11], [12], [13]
- Caveats
- The ulcer healing trials are small and were published from 1971 to 1982. The cimetidine comparison was single-blind with no placebo group [12]. The H. pylori trial measured clearance of the infection, not ulcer healing, and the abstract does not describe blinding [13].
Colorectal cancer
Limited evidence: one US study of postmenopausal women found red cell folate was not linked to colorectal cancer.
The numbers and sources
- Effect
- The odds ratio for colorectal cancer in the highest against the lowest quarter of red cell folate was 0.91 (95% CI 0.67 to 1.24), and the same comparison for plasma folate gave 0.91 (0.67 to 1.23). The results did not change across the periods before, during and after folic acid fortification of the US food supply [11].
- Population
- 988 women with colorectal cancer and matched controls, drawn from 93,676 postmenopausal women aged 50 to 79 in the Women's Health Initiative Observational Study [11].
- Sources
- [11]
- Caveats
- Observational, in postmenopausal women only, with folate measured once at enrollment [11].
Checked, no increase found13
Adverse events in antibiotic trials
Adverse events were about as common on probiotics as on control during antibiotics, 10.9% against 12.2%.
The numbers and sources
- How common
- Very common: more than 1 in 10 people.
- Effect
- In 37 trials (11,911 participants) on antibiotics, adverse events occurred in 10.9% on probiotics and 12.2% on control (RR 0.86, 95% CI 0.72 to 1.01, moderate certainty). The most common in both groups were abdominal cramping, nausea, fever, soft stools, flatulence and taste disturbance [11].
- Population
- Adults and children receiving antibiotics [11].
- Sources
- [11]
- Caveats
- Certainty was downgraded for variation between studies [11]. Trials with incomplete harms reporting are described below [47].
Adverse events in trials
Adverse events were about as common on ashwagandha as on placebo in trials up to 180 days, 5.6% against 9.2% in the largest.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- The BfR lists acute effects reported with ashwagandha, including nausea, vomiting, diarrhea, drowsiness, headache, dizziness and skin rash, and states that trials did not systematically record unwanted effects [19]. In a 2026 trial in 1,002 adults with stress and anxiety, 600 mg a day of root extract for 8 weeks produced no serious adverse events. Adverse events occurred in 5.6% on extract and 9.2% on placebo, and liver, kidney and blood tests did not differ [18]. A review of 23 trials of standardized root extract found no serious adverse events attributed to it, and mild gastrointestinal discomfort, headache and drowsiness in both groups [7]. The sleep meta-analysis reported no serious side effects in 5 trials [5].
- Population
- 1,002 adults aged 18 to 65 [18]. 2,317 healthy adults [7]. Trial participants and case reports [5][19].
- Sources
- [19], [18], [7], [5]
- Caveats
- Trials ran 180 days or less, so longer-term effects were not measured [7]. The root extract review covered single-ingredient root extracts in healthy adults only, and two of its authors reported employment by companies [7].
Side effects in clinical trials
Side effects were about as common on creatine as on placebo across 685 trials.
The numbers and sources
- How common
- Common: between 1 in 100 and 1 in 10 people.
- Effect
- Across 685 trials (12,839 on creatine, 13,452 on placebo), side effects were reported in 13.7% of creatine study arms and 13.2% of placebo arms. By participant, total side effect frequency was 4.60% on creatine and 4.21% on placebo. GI issues were 5.51% versus 4.05%, and muscle cramping or pain 0.52% versus 0.07%, neither significant by participant count [17].
- Population
- Clinical trial participants worldwide, plus adverse event databases [17].
- Sources
- [17]
- Caveats
- This is a pooled count, not a meta-analysis of randomized comparisons, and trials vary in how they collect side effects. The lead author also led the ISSN creatine position stand [4].
Adverse events in trials
Adverse events were about as common as on placebo across trials, and slightly less common in a 48-trial review. Serious events were rare.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In the Cochrane review, dropouts and adverse effects did not differ significantly from placebo, with a trend toward more dropouts for adverse events in prevention trials [1]. A 2019 meta-analysis found a risk ratio of 1.09 (95% CI 0.95 to 1.25) for adverse events [2]. In a 4-month trial of 755 adults, there were 293 adverse events on echinacea and 306 on placebo [8]. A 2026 meta-analysis of 48 trials (10,115 participants) found adverse events in 22.7% on echinacea and 24.8% on any control (p 0.014), and 29.1% against 32.3% when the control was placebo (p 0.005). Serious adverse events made up 0.09% of events on echinacea and 0.08% on control, with none fatal. In European spontaneous reports, the most common categories were gastrointestinal (17.7%), skin (16.1%), general (13.1%) and nervous system (10.3%, such as headache) [10].
- Population
- Trial participants [1][2][8][10]; EudraVigilance case reports [10].
- Sources
- [1], [2], [8], [10]
- Caveats
- Most trials were short. The 755-person trial tested Echinaforce, made by A. Vogel Bioforce AG, and its corresponding author's address is at bioforce.ch [8]. The 2026 meta-analysis mostly covered pharmaceutical-grade extracts, and its abstract does not report funding [10].
Inflammatory bowel disease
Not linked to inflammatory bowel disease in three meta-analyses of observational studies, though the label still lists it as a warning.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 8 studies of 2,522,422 people, isotretinoin was not associated with inflammatory bowel disease (OR 1.01, 95% CI 0.80 to 1.27), Crohn disease (OR 0.87) or ulcerative colitis (OR 1.27, 95% CI 0.94 to 1.73) [15]. A second meta-analysis of 6 studies found OR 1.08 (95% CI 0.82 to 1.42) [16], and a third pooled RR 0.94 (95% CI 0.65 to 1.36) across 5 studies [17]. The label states isotretinoin has been associated with the disease in people without prior bowel problems [3].
- Population
- 4 case-control and 4 cohort studies [15]; 6 studies [16]; 2,159 cases and 43,180 controls, plus 5 studies pooled [17].
- Sources
- [15], [16], [17], [3]
- Caveats
- All observational, and the three reviews share studies.
Adverse events in trials
Adverse events were about as common on boswellia as on placebo in knee osteoarthritis and Crohn's trials, which were mostly small and short.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Safety outcomes did not differ from placebo across knee osteoarthritis RCTs [2], and adverse events did not differ significantly in the 2026 network meta-analysis [3]. In the 52-week Crohn's trial, no safety disadvantages against placebo were observed [4]. Six patients on 4,200 mg a day reported minor gastrointestinal discomfort, with no severe adverse events [6]. A systematic review of 7 trials noted no serious safety issues [8].
- Population
- Trial participants [2][3][4][6][8].
- Sources
- [2], [3], [4], [6], [8]
- Caveats
- Most trials were small and short [2].
Adverse events in trials and reports
Adverse events were about as common as on placebo with single-ingredient Panax ginseng. Headache, sleep problems and gut complaints were the most common.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Trial data show adverse events with single-ingredient Panax ginseng at rates similar to placebo. Headache, sleep problems and gastrointestinal complaints were the most common. Serious events appear in isolated case reports, mostly with combination products where other ingredients may be responsible [11]. In erectile dysfunction trials, adverse events did not clearly differ from placebo (RR 1.45, 95% CI 0.69 to 3.03) [7].
- Population
- Trial participants and spontaneous reports [7][11].
- Sources
- [7], [11]
- Caveats
- The safety review dates from 2002 [11].
Side effects in trials
Side effects were about as common on NAC as on placebo, with a suggestion of more at higher doses.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Across 17 studies, the odds of side effects on NAC versus placebo were 1.11 (95% CI 0.88 to 1.39), with a suggestion of more side effects at higher doses [2]. In COPD trials, adverse reactions were not dose-dependent [3], and adverse events did not rise against control in a 2026 meta-analysis [4]. At 140 mg per kg as a solution, gastrointestinal reaction intensity was higher than placebo, while 70 mg per kg did not cause significant adverse reactions [10].
- Population
- Exercise trial participants [2][10]; COPD patients [3].
- Sources
- [2], [3], [4], [10]
- Caveats
- Side effect reporting varied across trials [2].
Side effects in trials
Side effects were about as common as on placebo in most trials, though one cognition review found more. Short trials cannot detect rare liver injury.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In osteoarthritis trials, adverse events on turmeric extracts were similar to placebo and 12% fewer than on NSAIDs [1]. In depression trials, digestive (OR 1.27, 95% CI 0.69 to 2.32) and neurological symptoms (OR 1.08) did not differ from control [25]. In COVID-19 trials, adverse events, mostly mild digestive symptoms, were comparable to placebo [40]. In 10 human cognition studies, adverse events were more frequent with curcumin than with control [39]. In 12 RCTs (1,303 people with diabetes), creatinine did not change (WMD -0.01 mg/dL, 95% CI -0.03 to 0.01) [52].
- Population
- Osteoarthritis, depression, COVID-19, cognition and diabetes RCTs [1][25][40][39][52].
- Sources
- [1], [25], [40], [39], [52]
- Caveats
- Trials of 16 weeks or less cannot detect the rare liver injury in the case series. The cognition review abstract does not give adverse event rates [39].
Adverse events
Small trials found no adverse events that doctors judged related to bilberry. Headaches were more frequent on extract in one trial, 18 of 55 against 11 of 54.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In 109 adults given 240 mg a day or placebo for 12 weeks, the full text reports headaches in 18 of 55 on extract and 11 of 54 on placebo, colds in 10 and 12, and stomach ache or diarrhea in 6 and 6. Physicians judged all events unrelated to the extract, and blood and urine tests showed no related changes [2]. In 88 office workers given 480 mg a day or placebo for 8 weeks, there were no severe adverse events in either group [6].
- Population
- 109 healthy adults aged 20 to 60 in Japan [2]. 88 office workers aged 20 to 40 in Japan [6].
- Sources
- [2], [6]
- Caveats
- Two trials of 8 to 12 weeks, too small to detect rare harms. The headache difference was not tested statistically in the trial report [2]. The second abstract reports only severe events [6].
Adverse events
Not found: no adverse events were reported for biofeedback in constipation trials, and in a double-blind ADHD trial events occurred as often with sham.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- No adverse events were reported for biofeedback in the Cochrane constipation review, though most trials did not report on harms [11]. In the double-blind ADHD trial, adverse events were distributed proportionally between neurofeedback and sham [8].
- Population
- 931 adults in 17 trials [11]. 142 children [8].
- Sources
- [11], [8]
- Caveats
- Harms were not systematically recorded in most trials [11].
Long-term use
One 12-month trial found 4 of 30 people on oral hyaluronic acid stopped with possible stomach side effects against 2 of 30 on placebo, a difference that was not significant.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- In 60 adults with knee osteoarthritis given 200 mg of oral hyaluronic acid or placebo daily for 12 months, possible side effects led to exclusion of 4 on hyaluronic acid, with stomach discomfort in 2, reflux in 1 and appetite loss in 1, and 2 on placebo, with skin itching or redness. The frequencies did not differ significantly, and none was shown to be caused by the capsules [6].
- Population
- 60 adults with knee osteoarthritis in Japan, 30 per group [6].
- Sources
- [6]
- Caveats
- One small trial, run with staff of the manufacturer, Kewpie Corporation [6]. No study longer than 12 months was located.
1 more
Diverticulitis
Not linked to more diverticulitis or diverticular bleeding in one cohort of 47,228 men followed for 18 years.
The numbers and sources
- How common
- How often is not known: the sources give no rate.
- Effect
- Men eating nuts at least twice a week had no higher risk of diverticulitis than men eating them less than once a month (HR 0.80, 95% CI 0.63 to 1.01, P for trend 0.04), and nuts were not linked to diverticular bleeding or uncomplicated diverticulosis [16].
- Population
- 47,228 US men aged 40 to 75, with 801 cases of diverticulitis [16].
- Sources
- [16]
- Caveats
- Observational, men only.
Not studied in people8
Digestion
Not studied in people. The diet's idea that food lectins clash with blood types rests on lab work, which found lectins common in foods but no blood-type-specific clumping.
No study in people. This rests on lab studies, how it acts in the body.
The numbers and sources
- Effect
- A systematic review found no study of any health effect of blood-type diets, digestion included [1]. The diet proposes that lectins, sugar-binding proteins in some foods, cause clumping when they do not suit a person's ABO blood type [2]. In a lab survey, 29 of 88 common foods, including salad ingredients, fresh fruits, roasted nuts and processed cereals, showed lectin activity in agglutination tests [5]. The authors of a 2014 study, citing that survey, wrote that studies to date suggest no ABO-specific agglutination [2].
- Population
- Food extracts tested in the lab [5]. A systematic review [1] and the background of a study in 1,455 adults [2].
- Sources
- [1], [2], [5]
- Caveats
- Lectin activity in a test tube does not show what happens in the gut. No study measured digestive symptoms on a blood-type diet [1].
Gut healing
Not studied in people. Rat studies report colitis counteracted, and surgical joins in the intestine and fistulas healed.
No study in people. This rests on animal studies.
The numbers and sources
- Effect
- A 2012 review reports that in animal studies BPC-157 healed intestinal anastomoses, reversed short bowel syndrome and healed fistulas, and describes an antiulcer effect [22]. A 2024 review of rat studies reports that BPC-157 healed surgical joins at several points along the gut, counteracted colitis, esophagitis and short bowel syndrome, and healed fistulas running from the colon, stomach, esophagus or duodenum to the skin [23].
- Population
- Rats [22][23].
- Sources
- [22], [23]
- Caveats
- The 2012 review states that BPC-157 was tested in inflammatory bowel disease in a phase II clinical trial [22]. No published results of that trial were located for this page, so it is not graded here. FDA found no studies giving BPC-157 to humans by mouth [3].
Digestion
Not studied in people. In mice, bromelain raised pancreatic trypsin activity and shifted gut bacteria, and high doses loosened a lab model of human gut lining.
No study in people. This rests on animal studies, lab studies.
The numbers and sources
- Effect
- Healthy young mice fed 1 mg of bromelain a day for 3 days showed higher pancreatic trypsin activity, a thicker ileal lining, fewer Proteobacteria and more Akkermansia muciniphila in the gut. In a reconstructed human intestinal tissue model, the highest dose disrupted the tissue barrier and raised its permeability [12].
- Population
- C57BL/6 mice and a human 3D intestinal tissue model [12].
- Sources
- [12]
- Caveats
- A 3-day mouse study and a tissue model do not show an effect on digestion in people [12]. No trial of bromelain as a digestive aid in people was located. One 8-week trial in 70 people with ulcerative colitis found lower disease activity scores on 400 mg a day than placebo, with no change in quality of life, which is a different question from everyday digestion [13].
Hemorrhoids
Not studied in people. The EU herbal committee accepts butcher's broom root for itching and burning of hemorrhoids on the basis of at least 30 years of use.
No study in people. This rests on documented traditional use.
The numbers and sources
- Effect
- The European Medicines Agency's herbal committee concluded that, on the basis of long-standing use, butcher's broom root preparations can be used to relieve itching and burning of hemorrhoids after a doctor has ruled out serious conditions. It states that no studies in patients with hemorrhoids have been carried out with butcher's broom, and that traditional use means the effect is plausible and there is a record of use this way for at least 30 years, 15 of them in the EU [6].
- Population
- A regulator's review of traditional use in the EU [6].
- Sources
- [6]
- Caveats
- Traditional use is a record of how long it has been used, not a test of its effect [6]. Old French and German reports on Ruscus in proctology were located but have no abstracts to read.
General health and detox from colon cleansing
Not studied in people in rigorous controlled trials. The detox idea rests on the old theory of autointoxication, that bowel waste poisons the body.
No study in people. This rests on how it acts in the body, documented traditional use.
The numbers and sources
- Effect
- A systematic review of conventional and alternative medicine literature found no methodologically rigorous controlled trials of colonic cleansing for general health promotion, and multiple case reports and case series of adverse effects [6]. A history of the practice traces it to autointoxication, the 19th century doctrine that intestinal waste products poison the body, which declined once its scientific rationale was shown to be wrong [7].
- Population
- No trial population. A systematic review [6] and a historical review [7].
- Sources
- [6], [7]
- Caveats
- No study located measured toxins removed from the body by colon cleansing.
Coffee enemas for detox and cancer
Not studied in people for effectiveness. A systematic review found no study reporting any benefit, and coffee enemas are used by naturopathic practitioners for detox and cancer.
No study in people. This rests on documented traditional use, what users report.
The numbers and sources
- Effect
- A systematic review searched Western and East Asian databases for any study of self-administered coffee enema effectiveness and found none. People use them for self-care and detoxification [10]. A case report notes their use by naturopathic practitioners for many diseases, including cancer [11].
- Population
- No study population. A systematic review [10] and a case report [11].
- Sources
- [10], [11]
- Caveats
- Use is not evidence of effect.
Digestion
Not studied in people. The EU herbal committee accepts dandelion root with herb for mild digestive symptoms and temporary loss of appetite on the basis of long-standing use.
No study in people. This rests on documented traditional use.
The numbers and sources
- Effect
- The European Union herbal monograph lists dandelion root with herb as a traditional herbal medicinal product for the relief of symptoms of mild digestive disorders, such as a feeling of fullness, flatulence and slow digestion, and temporary loss of appetite. It states the indication rests exclusively on long-standing use [6].
- Population
- A regulator's review of traditional use in the EU [6].
- Sources
- [6]
- Caveats
- Traditional use records how a herb has been used, not a measured effect. No trial of dandelion for digestion was located.
Gut inflammation and colitis
Not studied in people. In mice and rats with induced colitis, KPV reduced colon inflammation and weight loss.
No study in people. This rests on animal studies, lab studies.
The numbers and sources
- Effect
- In human intestinal and immune cell lines, KPV entered cells through the PepT1 transporter, inhibited NF-kappaB and MAP kinase inflammatory signaling, and reduced pro-inflammatory cytokine secretion. Given in drinking water, it reduced DSS- and TNBS-induced colitis in mice, with lower pro-inflammatory cytokine expression [8]. In two mouse colitis models, KPV-treated mice recovered earlier, regained more body weight and had fewer inflammatory cells in the colon. In mice with a nonfunctional melanocortin-1 receptor, KPV kept all treated animals alive through DSS colitis [9]. KPV delivered by mouth in nanoparticles reduced mucosal damage and TNF-alpha in a mouse model of ulcerative colitis [10]. KPV in a rectal hydrogel reduced weight loss, disease activity scores, colon shortening and inflammatory cytokines in rats with TNBS colitis [11].
- Population
- Mice and rats with chemically induced or transfer colitis, and human cell lines in the lab [8][9][10][11].
- Sources
- [8], [9], [10], [11]
- Caveats
- Colitis induced in rodents does not show what happens in people with inflammatory bowel disease. Two of the studies gave KPV inside a delivery system, nanoparticles or a hydrogel, rather than on its own [10][11]. FDA found no clinical studies or human exposure data for KPV by any route [3].